Proceedings of the National Academy of Sciences
Articles in this Issue
SlPLT6 controls ripening initiation and quality traits through modulation of histone acetylation and methylation in tomato
Improving fruit growth and quality without compromising yield is a highly sought-after goal in crop breeding. Here, we report that an EAR motif-containing transcription factor SlPLT6 controls the onse...
Induction of a neurotoxin in diatoms by iron limitation via cysteine synthase
The β- N -methylamino- L -alanine (BMAA) is an emerging neurotoxin associated with human neurodegenerative diseases such...
Solution mapping of MHC-I:TCR interactions using a minimalistic protein system
Recognition of epitopic peptide antigens presented on class I major histocompatibility complex (MHC-I) proteins by T cell receptors (TCRs) forms the cornerstone of immune surveillance, leading to a pl...
Impact of large-scale solar on property values in the United States: Diverse effects and causal mechanisms
As the renewable energy transition continues into less receptive communities, local opposition is expected to intensify, potentially slowing the process. Since the local impacts are neither well quant...
Organellar genome divergence and environmental stress induce transcriptional cytonuclear responses in wheat alloplasmic hybrids
The union of two or more different nuclear genomes with maternally inherited organellar genomes may lead to cytonuclear incompatibilities in plant allopolyploids. These incompatibilities may be reconc...
The CARD14 <i>sh</i> –BCL10–MALT1 complex regulates MAVS-mediated antiviral response in keratinocytes
The Mitochondrial Antiviral Signaling Protein (MAVS) is a key adaptor in antiviral immunity, mediating type I interferon responses downstream of RIG1 and TLR3. While MAVS regulation is essential for a...
Homology-arm length of donor DNA affects the impact of Msh2 loss on homologous recombination–mediated gene targeting
Efficient targeted integration (TI) of homologous donor DNA is crucial for precise genome editing. Although mismatch repair (MMR) is known to suppress TI as well as homologous recombination (HR) when...
No mass extinction for South American mammals at the Eocene–Oligocene transition
Psychoactive plants and secret rituals in ancient Peru
Built-in redundant killing by Bt Cry1Ab toxin delays insect resistance
Predicting high-fitness viral protein variants with Bayesian active learning and biophysics
The early detection of high-fitness viral variants is critical for pandemic response, yet limited experimental resources at the onset of variant emergence hinder effective identification. To address t...
Early evidence for pig domestication (8,000 cal. BP) in the Lower Yangtze, South China
The domestication of pigs ( Sus scrofa ) has had profound socioeconomic and ecological consequences. Although pigs are believed to have been independently domes...