Proceedings of the National Academy of Sciences
Articles in this Issue
An integrated mechanism of G <sub>q</sub> regulation of PLCβ enzymes
Phospholipase Cβ (PLCβ) enzymes are the principal effectors activated by G q heterotrimers. Both Gα q and Gβγ subunits c...
<i>miR-155</i> impairs ICOSL and MHC-I expression in DLBCL lymphomas
Elevated miR-155 levels in B cell malignancies, such as CLL and DLBCL, correlate with increased aggressiveness of the disease. We recently reported that, in two...
Thermotropic reentrant isotropic symmetry and induced smectic antiferroelectricity in the ferroelectric nematic material RM734
We report a transition from the ferroelectric nematic liquid crystal (N F ) phase to a lower-temperature, apolar fluid phase having reentrant isotropic symmetry...
Force spectroscopy reveals membrane fluctuations and surface adhesion of extracellular nanovesicles impact their elastic behavior
The elastic properties of nanoscale extracellular vesicles (EVs) are believed to influence their cellular interactions, thus having a profound implication in intercellular communication. However, accu...
Unified molecular approach for spatial epigenome, transcriptome, and cell lineages
Spatial epigenomics and multiomics can provide fine-grained insights into cellular states but their widespread adoption is limited by the requirement for bespoke slides and capture chemistries for eac...
Correction to Supporting Information for Li et al., Primed 3D injectable microniches enabling low-dosage cell therapy for critical limb ischemia
MFRP is a molecular hub that organizes the apical membrane of RPE cells by engaging in interactions with specific proteins and lipids
Membrane frizzled-related protein (MFRP), present in the retinal pigment epithelium (RPE), is an integral membrane protein essential for ocular development and the normal physiology of the retina. Mut...
Bidirectional disruption of <i>GNAS</i> transcripts causes broad methylation defects in pseudohypoparathyroidism type 1B
Pseudohypoparathyroidism type 1B (PHP1B) is a multihormone resistance disorder caused by aberrant GNAS methylation. Characteristic epigenetic changes at...
Evaluating interdisciplinary research: Disparate outcomes for topic and knowledge base
Interdisciplinary research is essential for addressing complex global challenges, but there are concerns that scientific institutions like journals select against it. Prior work has focused largely on...
ATM priming and end resection–coupled phosphorylation of MRE11 is important for fork protection and replication restart
The MRE11/RAD50/NBS1 (MRN) complex plays multiple roles in the maintenance of genome stability. MRN is associated with replication forks to preserve fork integrity and is also required for end resecti...
The pentameric chloride channel BEST1 is activated by extracellular GABA
Bestrophin-1 (BEST1) is a chloride channel expressed in the eye and other tissues of the body. A link between BEST1 and the principal inhibitory neurotransmitter γ...
Structural basis of excitatory amino acid transporter 3 substrate recognition
Excitatory amino acid transporters (EAATs) reside on cell surfaces and uptake substrates, including L-glutamate, L-aspartate, and D-aspartate, using ion gradients. Among five EAATs, EAAT3 is the only...
Correction for Gasparin et al., Combining exchangeable <i>P</i> -values
Mapping global brain reconfigurations following local targeted manipulations
Understanding how localized brain interventions influence whole-brain dynamics is essential for deciphering neural function and designing therapeutic strategies. Using longitudinal functional MRI data...
Correction for Yardeni et al., Mitochondrial DNA lineages determine tumor progression through T cell reactive oxygen signaling
CB-1 receptor agonist drastically changes oscillatory activity, defining active sleep
Brain oscillations in different behavioral states are essential for cognition, and oscillopathies contribute to cognitive dysfunction in neuropsychiatric diseases. Cannabis-1 receptor (CB1-R) activati...
Intraflagellar transport trains can switch rails and move along multiple microtubules in intact primary cilia
Structural homeostasis and proper distributions of signaling molecules in cilia require a constant flow of cargoes carried by intraflagellar transport (IFT) trains in both anterograde and retrograde d...
Flocking and giant fluctuations in epithelial active solids
The collective motion of epithelial cells is a fundamental biological process which plays a significant role in embryogenesis, wound healing, and tumor metastasis. While it has been broadly investigat...
Integratable all-solid-state thin-film microbatteries
Large-scale integration of microbattery systems on chips has long been hindered by the technical barrier between electrochemistry and microelectronics, particularly in terms of the compatibility of mi...
Functional redundancy in the toxic pathway of Bt protein Cry1Ab, but not Cry1Fa, against the Asian corn borer
Crops genetically engineered to produce insecticidal proteins from the bacterium Bacillus thuringiensis (Bt) have been used extensively to control some major cr...
Cleavage cascade of the sigma regulator FecR orchestrates TonB-dependent signal transduction
TonB-dependent signal transduction is a versatile mechanism observed in gram-negative bacteria that integrates energy-dependent substrate transport with signal relay. In Escherichi...
Diet-regulated transcriptional plasticity of plant parasites in plant–mutualist environments
Crop pathogens often lack exclusive access to their host and must interact with plants concurrently engaged with numerous other symbionts. Here, we demonstrate that the colonization of hosts by plant–...
Elevated brain manganese induces motor disease by upregulating the kynurenine pathway of tryptophan metabolism
Elevated brain levels of the essential metals manganese (Mn), copper, or iron induce motor disease. However, mechanisms of metal-induced motor disease are unclear and treatments are lacking. Elucidati...
Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryoelectron tomography
Influenza viruses are enveloped, negative-sense single-stranded RNA viruses covered in a dense layer of glycoproteins. Hemagglutinin (HA) accounts for 80 to 90% of influenza glycoprotein and plays a r...
Sleep homeostasis in lizards and the role of the cortex
Slow-wave sleep (SWS) and rapid eye movement sleep are the two primary components of electrophysiological sleep (e-sleep) in mammals and birds. Slow waves in the cortex not only characterize SWS but a...