Proceedings of the National Academy of Sciences
Articles in this Issue
Time-resolved morphological and transcriptomic characterization of early enteric neuron subtype emergence in chick
The genetic programs directing nascent enteric nervous circuits and their unique architecture remain poorly characterized. To gain insight, we combined manipulations in the chick embryo model, whole g...
Turning policy implications into policy impact: Lessons from behavioral science in financial markets
We describe how research can inform policymaking. We begin by summarizing the policy formation process, offering a framework illustrating how interactions between scientists and policymakers can provi...
Bumblebees’ orofacial reactions to tastes provide evidence for affective evaluation
Facial expressions provide a critical window into the internal states of animals, allowing the identification of affective processes and their underlying neural mechanisms. In mammals, postconsumption...
Science in service: Behavioral research applications across federal agencies
Strengthening of negative fire–fuel feedbacks by large fires in eastern Canadian boreal forests
Fire-induced reductions in biomass limit the likelihood of reburning during early vegetation recovery in several crown-fire ecosystems; however, it is unclear how this negative fire–fuel feedback will...
Educational expansion and the hidden reversal of the Flynn effect—Differential trends across socioeconomic strata
In recent decades, the United States and several European countries have seen a plateau and reversal of the population-level gains in cognitive test scores that accumulated over the 20th century—the F...
Fracture-driven weakening amplifies projected ice loss from West Antarctica
Ice shelves buttress the flow of the Antarctic ice sheet, but this stabilizing effect weakens as fractures form, reducing ice viscosity and accelerating ice discharge toward the ocean. Here, we incorp...
Differences in physiological tolerance to global warming caused the Permian–Triassic transition between the Paleozoic and Modern faunas
The rapid global climate change at the end of the Permian Period (~251.9 Mya) coincided with the greatest macroevolutionary faunal turnover event in Earth’s history. As the oceans warmed, lost dissolv...
Histone chaperone HIRA regulates adiponectin expression and obesity-associated adipose expansion by facilitating Pol II pause release
Adipose tissue is essential for maintaining glucose and lipid homeostasis in mammals. However, epigenomic mechanisms underlying adipose tissue function remain largely unclear. Here, we identify the hi...
Dolphins use names to remember whom to avoid
Long-term stability and performance of Cas9/guide RNA-based gene drives in anopheline mosquitoes
Gene-drive population modification strategies are being developed to control the transmission by anopheline mosquitoes of the parasites that cause human malaria. These approaches are designed to reduc...
Spatial transcriptomic mapping of postnatal mouse uterine development
Postnatal uterine development requires precise coordination of epithelial differentiation, gland formation, and stromal organization, yet how transcriptional programs are spatially integrated during t...
Payment integrity in government programs: Takeaways from incorporating the behavioral sciences in US federal evaluations
A primary way the US federal government delivers public goods and services is via monetary payments. Ensuring that these payments are calculated accurately, delivered on time, and made to the correct...
Energy costs of Hannibal’s alpine crossing
Hannibal crossed the Alps with a large army containing 37 war elephants in 218 BC. Details of his route have scholars regularly debate historical reports in the light of logistical and topographical c...
Invariant nonequilibrium dynamics in gene regulation optimize information flow
Eukaryotic gene regulation relies on stochastic yet controlled promoter switching, in which genes transition between transcriptionally active and inactive states. Despite the molecular complexity of t...
Retraction for Shaked and Frenkel, Curiouser and curiouser: Meningeal lymphoid structures in the aging brain
Evidence from formal logical reasoning reveals that the language of thought is not natural language
Humans are endowed with a powerful capacity for inductive and deductive logical thought: we easily form generalizations based on a few examples and draw conclusions from known premises. Humans also ar...
Correction for Brodeur et al., AI-assisted teams outperform AI-led teams but not human-only teams in assessing research reproducibility in quantitative social science
Selective and direct hydrogen generation from mixed plastic waste via alkaline thermal treatment with inherent carbon storage
The global accumulation of plastic waste has spurred extensive research into chemical recycling methods to mitigate environmental issues and convert waste into valuable resources. A major challenge in...
Interleukin-6 is critical in the development of pulmonary vascular disease in <i>Gcn2-</i> deficient mice
Biallelic mutations in EIF2AK4, encoding Eukaryotic Translation Initiation Factor 2α kinase 4 or General Control Nonderepressible 2 (GCN2), cause pulmonary veno-occlusive disease (PVOD), a fatal form...
Mathematical misdefinition of adjusted cloud-fraction change limits isolation of aerosol effects
Domesticated, not feral: Why evolvable AI is not yet a Darwinian threat
Reply to Boudry: The threat of evolvable AI is too grave to be left to intuition
Reply to Yu et al.: Meteorological covariations do not reproduce diurnal cloud fraction response to aerosol
The emergence of human influence on the ozone layer by the 1960s
The Antarctic ozone hole was first reported in 1985, and small ozone losses at the global scale were also observed in the late 1980s. The combination of field and laboratory measurements, together wit...