Proceedings of the National Academy of Sciences
Articles in this Issue
Aridity-induced energy reallocation from green to brown food webs predicts grassland carbon storage
Increasing aridity is predicted to alter the structure and functioning of soil food webs, yet its impacts on grassland food-web energetics and the resulting consequences for soil carbon sequestration...
SLC25A3 exports mitochondrial copper to metalate cytochrome <i>c</i> oxidase and prevent cuproptosis
Copper (Cu) is an essential cofactor for cytochrome c oxidase (CcO), a mitochondrial respiratory chain enzyme that is metalated in the intermembrane space (IMS)...
Reclassification and weighting of multiple causes of death: US death certificates 2003–2023
Death certificates record causes of death as reported by certifiers (Entity Axis) and as standardized by mortality coding rules (Record Axis). Conventional statistics reduce these to a single underlyi...
Selectively targeting inosine monophosphate dehydrogenase-2 impairs brain metastatic potential while preserving immune cell function
Brain metastases (BM) occur in 26% of cancer patients and have a 90% mortality rate within 1 y of diagnosis, yet the current standard of care remains palliative. We have previously shown that de novo...
Supersaturation-controlled assembly pathway directs hierarchical chirality expression in ionic luminophores
The controlled expression of molecular chirality across multiple length scales is a central feature of many natural assemblies, yet remains a significant challenge to achieve in synthetic materials. H...
ENO1 couples HDAC1 to regulate histone lactylation and gene transcription
Histone deacetylases (HDACs) regulate transcription and catalyze deacetylation predominantly within canonical transcriptional complexes. Nevertheless, the mechanistic role of other HDAC-associated pro...
Linear-time prediction of proteome-scale microbial protein interactions
Protein–protein interactions (PPIs) underpin biological function, yet proteome-scale interaction prediction remains bottlenecked by the quadratic computational complexity of all-vs.-all pairwise compa...
Shared spatial and temporal principles govern connectome dynamics across timescales
While the brain processes information at various speeds, little is known about how the functional connectome can concurrently support multiple speeds in parallel. FMRI and electrophysiological modalit...
Opposing range-dependent interactions create complex spatial patterns of antibiotic tolerance in multispecies biofilms
Many microbial communities form multispecies biofilms where cells interact through diffusible molecules. In these biofilms, multiple interactions, often with opposing effects, occur simultaneously, ye...
A teleost-specific oxygen–immunity axis where FIH activates NF-κB via competitive IκBα binding
Global warming–induced aquatic deoxygenation poses a severe physiological challenge to teleosts, often influencing their immune defense mechanisms. While aquatic organisms are under evolutionary press...
State-switching navigation strategies in <i>Caenorhabditis elegans</i> are beneficial for chemotaxis
Animals employ different strategies for relating sensory input and behavioral output to navigate sensory environments, but what strategy to use, when to switch and why remain unclear....
Dual-chirality flexagon linkages with infinite eversion and surface reconfigurability
The flexagon, a classical kirigami structure capable of revealing hidden faces through eversion, has long captivated researchers. However, its potential for robust engineering applications has been li...
Dynamic monitoring of antibody drug conjugates targeting TROP2 or HER2 in breast cancer using circulating tumor cells
Antibody–drug conjugates (ADCs) target surface proteins on cancer cells, leading to internalization and delivery of a drug payload, thereby enhancing selectivity and minimizing toxicity. ADCs against...
A genome-wide CRISPR screen reveals how diatoms thrive in dynamic light
Diatoms are a highly diverse algal group with outsized impact on global primary production and marine carbon sequestration. They are red lineage phototrophs of complex endosymbiotic origin and therefo...
Direct demonstration of electric chirality control in a helimagnetic YMn <sub>6</sub> Sn <sub>6</sub> by spin-polarized neutron scattering
The spiral handedness of magnetic moments, referred to as chirality, gives rise to emergent electromagnetic phenomena in helimagnets. In insulating helimagnets, known as multiferroics, the cycloidal s...
The exocyst subunits OsEXO70L2 and OsSEC3A regulate root development through modulating OsPIN1a/b-mediated auxin distribution in rice
Exocyst complex–mediated vesicle trafficking is essential for plant growth and development, yet its roles in crop root development remain poorly understood. Previously, we showed that mutation of the...
Structure of Human adenovirus 7 virus-like particles, a platform for developing nanotherapeutics and studying capsid assembly
Adenoviridae family members routinely infect humans, exhibit significant genetic diversity, and are associated with a variety of illnesses. Types 4 and 7 frequently circulate in the United States and...
Estimating the amount of computation done by a brain using population neural activity
Many dynamical systems, ranging from genetic circuits to the human brain to human social systems, are often characterized as computational. Although extensive research has explored their dynamics, the...
Computational design and cellular synthesis of two protein topological isomers: Solomon link vs. three-twist knot
Chemical topology has emerged as a unique dimension in protein engineering, motivating the pursuit of topologically nontrivial protein architectures for functional advantages, such as enhanced stabili...
An atlas of microtubule lattice parameters regulated through ligand binding to the microtubule-stabilizing sites
Microtubules are dynamic cytoskeletal polymers whose lattice architecture regulates force generation, nucleotide hydrolysis, and recognition by motor proteins and microtubule-associated proteins (MAPs...
Wounding-induced redirection of sugar transport fuels tissue repair
Wounding triggers growth programs to restore damaged tissues, creating a local surge in metabolic demand. How resource recruitment is modified to meet this demand is unclear. Here, we show that regene...
Spatiotemporal transcriptome atlas reveals the dynamic cellular and molecular characteristics of ovule development in gymnosperms
Ovule, as the developmental precursor to seed, represents a key evolutionary innovation in seed plants. However, its origin and evolutionary trajectory have been debated for over a century, largely du...
A bacterial symbiont and a plant virus enhance insect fitness by inducing physical defenses against fungal parasites
Defensive symbioses in which beneficial microbes protect hosts from natural enemies are ubiquitous across animals and plants, but the underlying mechanisms remain poorly understood. Field surveys and...
DMD-Null mice exhibit severe muscle weakness, impaired regeneration, and deficient satellite cell function
Duchenne muscular dystrophy (DMD) is a debilitating and fatal X-linked disease affecting 1/5,000 males worldwide that currently has no cure [D. Duan, N. Goemans, S. Takeda, E. Mercuri, A. Aartsma-Rus,...
Elevated MyoD1 levels expand genome-wide binding and the repertoire of regulated genes
Transcription factor (TF) upregulation accompanies many cellular state transitions, yet how increased TF abundance impacts gene regulation remains unclear. Two broad models are often invoked, whereby...