Proceedings of the National Academy of Sciences
Articles in this Issue
Late Cenozoic river reorganization related to tectonic extrusion formed the modern drainage system in southeastern Tibet
The formation and organization of southeastern Tibetan river systems reflect feedbacks between tectonics, climate, and landscape evolution. However, our understanding of these interactions remains unc...
Recent drying of the Ganga River is unprecedented in the last 1,300 years
The Ganga River basin, critical to over 600 million people, is experiencing a severe and unprecedented drying trend, threatening water and food security. Using streamflow reconstructions spanning 1,30...
Correction for Wurman et al., Supercell tornadoes are much stronger and wider than damage-based ratings indicate
Overcoming the space clamp effect: Reliable recovery of local and effective synaptic conductances of neurons
Neurons process information by integrating thousands of synaptic inputs along their dendrites. Understanding the computational principles underlying neuronal information processing requires a reliable...
Fiber recruitment drives a phase transition of cell polarization at a critical cell spacing in matrix-mediated tissue remodeling
Biological tissues exhibit sharp phase transitions where cells collectively transition from disordered to ordered states at critical densities. We demonstrate through bio-chemo-mechanical modeling tha...
Global constraint principle for microbial growth laws
Understanding complex living systems requires identifying universal phenomenological laws that are independent of species and molecular-biological details. The Monod equation is a cornerstone of pheno...
Correction for Jin et al., Autocrine signaling by an <i>Aplysia</i> neurotrophin forms a presynaptic positive feedback loop
High rates of polygyny do not lock large proportions of men out of the marriage market
There is a widespread belief, in both the scholarly literature and the popular press, that polygyny prevents large numbers of men from marrying by skewing the sex ratio of the marriage market. In turn...
Targeting the 3D genome by anthracyclines for chemotherapeutic effects
The chromatin is folded into three-dimensional (3D) structures, and aberrant 3D chromatin folding has been implicated in cancer. We performed ATAC-seq and TOP2A ChIP-seq to assess the potential effect...
Electronic origin of the anomalous melting of sodium under pressure
Despite extensive experimental and theoretical investigations, the fundamental electronic origin of compressed sodium’s melting temperature reversal under pressure, characterized by a maximum and a mi...
Proof-of-principle demonstration of epithermal neutron resonance spectroscopy utilizing a compact laser–driven electron accelerator
Epithermal neutron resonance spectroscopy is a key nondestructive approach for discerning material properties. However, the existing spallation and accelerator-based photonuclear neutron sources emplo...
Autoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility
Genetic association links disordered autoimmunity 1 (DIORA1) to numerous autoimmune rheumatic diseases, including systemic lupus erythematosus, Sjögren’s disease, rheumatoid arthritis, polymyositis, a...
When crops fail, forests follow: Agricultural shocks and deforestation in Zambia
As climate change makes agricultural production shocks more frequent and severe, it is vital to understand their effect on farmer welfare, land use, and deforestation. Theoretically, a change in agric...
Combined pesticide pollution enhances the dissemination of the phage-encoded antibiotic resistome in the soil under nitrogen deposition
Phage-mediated dissemination of antibiotic resistance genes (ARGs) intensifies health threat in the environment. Increasing amounts of pesticides are entering the soil ecosystem, yet their potential i...
Density-dependent recruitment but not survival drives cyclic dynamics in a field vole population
Arguably, the most fundamental question in population ecology is what drives patterns in the abundance of populations? Small rodents exhibiting regular multiannual cycles in abundance have long been a...
Geometrical compartmentalization of trigger waves
Trigger waves, self-regenerating fronts of biochemical activity that spread without losing speed or amplitude, are widespread in cell signaling. Apoptosis is one example of a process that propagates t...
Mouse X-linked microRNA cluster regulates the meiotic checkpoint and <i>Prdm9</i> -driven hybrid sterility in a copy number–dependent manner
One of the reproductive barriers between diverging populations during formation of a new species is the sterility of their hybrids. The Prdm9- driven hybrid mal...
Chemobiological synthesis of benzene, toluene, ethylbenzene, and xylene from glucose or glycerol
Benzene, toluene, ethylbenzene, and p -xylene (BTEX) are key aromatic hydrocarbons widely used in fuels, polymers, and industrial chemicals, yet their productio...
Enhanced PIEZO1 function contributes to the pathogenesis of sickle cell disease
Sickle cell disease (SCD), an inherited blood disorder caused by a mutation in the β-globin gene, is characterized by sickle erythrocytes that are prone to hemolysis, leading to anemia and vaso-occlus...
Reaction-induced departures from continuum Navier–Stokes turbulence
Reactive hydrodynamic turbulence is an inherently multiscale phenomenon, characterized by the separation between energy-containing, viscous, and molecular length and time scales. The separation betwee...
A chemical epigenetic tool to probe site-specific DNA-binding protein complexes
Site-specific DNA binding by proteins is critical for regulating transcriptional activity and cell fate decision. However, identifying proteins bound to specific genomic regions (e.g., promoter or enh...
Soluble guanylyl cyclase, the NO receptor, drives vasorelaxation via endothelial S-nitrosation
We previously demonstrated that the NO-stimulated soluble guanylyl cyclase (GC1), which produces cGMP, also has the ability to transfer S-nitrosothiols (SNO) to other proteins in a reaction involving...
From propulsion to suction: Unraveling thrust reversal in propellers at intermediate Reynolds numbers
This study investigates propeller hydrodynamics at intermediate Reynolds numbers ( Re ), crucial for small-scale robotic systems but still uncharted. Experiment...
The intrinsic neuronal network of the central nervous system and its modular (subsystem) architecture in a mammal
The vertebrate central nervous system (CNS) has two great topographic divisions—brain and spinal cord—that together integrate the body’s internal physiology and behavioral interactions with the enviro...
Electrostatics and viscosity are strongly linked in concentrated antibody solutions
Monoclonal antibodies are among the most promising therapeutic agents in modern medicine, yet their formulation into high-concentration solutions for subcutaneous self-administration poses a major cha...