Proceedings of the National Academy of Sciences
Articles in this Issue
Evidence for coopetition at the maternal–fetal interface shaping placental invasion
Coopetition is a term from game theory that describes a mix of cooperative and competitive behavior. The maternal–fetal interface (MFI) among eutherian mammals presents close interaction of two distin...
A thermodynamic perspective on mammalian neural crest ingression
The ingression of neural crest cells from an ectodermal to a mesodermal layer is regulated by instructive, directional cues and potentially stochastic, biophysical parameters such as differential cell...
Complementary biomolecular coassemblies direct energy transport for cardiac photostimulators
Charge and energy transport within living systems are fundamental processes that enable the autonomous function of excitable cells and tissues. To date, localized control of these transport processes...
Topology and kinetic pathways of colloidosome assembly and disassembly
Closed capsules, such as lipid vesicles, soap bubbles, and emulsion droplets, are ubiquitous throughout biology, engineered matter, and everyday life. Their creation and disintegration are defined by...
A general genome editing strategy using CRISPR lipid nanoparticle spherical nucleic acids
Genome editing with CRISPR–Cas systems hold promise for treating a wide range of genetic disorders and cancers. However, efficient delivery of genome editors remains challenging due to the requirement...
Preschool teachers provide fewer participation opportunities to working-class students than those from more privileged backgrounds
Social class disparities exist from the earliest stages of education. Research has suggested that class-based differences in factors such as socialization practices and access to resources partly expl...
Bouncing microdroplets on hydrophobic surfaces
Intuitively, slow droplets stick to a surface and faster droplets splash or bounce. However, recent work suggests that on nonwetting surfaces, whether microdroplets stick or bounce depends only on the...
Collective behavior of “flexicles”
In recent years the functionality of synthetic active microparticles has edged even closer to that of their biological counterparts. However, we still lack the understanding needed to recreate at the...
12/15-lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammation
12/15-lipoxygenase (12/15-LOX, Alox15 ) generates bioactive oxygenated lipids during inflammation, however its homeostatic role(s) in normal healing are unclear...
Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria
Circadian clocks allow organisms to anticipate daily fluctuations in light and temperature, but how this anticipatory role promotes adaptation to different environments remains poorly understood. Here...
De novo design of protein binders to stabilize monomeric TDP-43 and inhibit its pathological aggregation
Pathological aggregation of transactive response DNA binding protein of 43 kDa (TDP-43), primarily driven by its low-complexity domain, is closely associated with various neurodegenerative diseases, i...
Loss of the ESX-5 secretion locus in <i>Mycobacterium tuberculosis</i> reshapes the mycomembrane and enhances ESX-1 substrate secretion
The ESX-5 secretion system, uniquely found in slow-growing mycobacteria, is predicted to secrete over 150 proteins across the inner membrane of Mycobacterium tuberculosis...
William S. Sly (1932–2025): A compassionate pioneer in biochemical genetics
William S. Sly, MD (1932–2025) was a biochemical geneticist who received his medical degree from Saint Louis University. He received additional training at the NIH with several members of the National...
Procollagen IIA mediates positive feedback control of the mouse cardiogenic transcriptional network
Cardiogenesis relies on the integrated interplay between cardiac transcription factors and signaling pathways. Here, we uncover a role for type IIA procollagen (IIA), an extracellular matrix (ECM) pro...
Inverse stable isotope probing–metabolomics (InverSIP) identifies an iron acquisition system in a methane-oxidizing bacterial community
Methane is a potent greenhouse gas and a target for near-term climate change mitigation. In many natural ecosystems, methane is sequestered by microbial communities, yet little is known about how cons...
Capturing the native structure of membrane proteins using vesicles
Membrane proteins play crucial roles in numerous biological processes and are important drug targets. However, structural studies of membrane proteins often rely on solubilization with detergents, whi...
Fatty acid 2-hydroxylase facilitates rotavirus uncoating and endosomal escape
Despite the clinical significance of many nonenveloped viruses, the molecular mechanisms of their internalization and membrane penetration are not well understood. Rotaviruses (RVs) are nonenveloped d...
Upscaling behavioral interventions requires addressing selection bias
Nonlinear memory in cell-division dynamics across species
Regulation of cell growth and division is essential to achieve cell-size homeostasis. Recent advances in imaging technologies, such as “mother machines” for bacteria or yeast, have allowed long-term t...
Manipulating anthracyclines for deeper tissue penetration and implications for glycolytic tissues
How drugs penetrate tissues is poorly understood yet important, since drugs that fail to reach their target will be ineffective. We followed the fate of anthracycline cancer drugs at high resolution b...
<i>miR444b.2</i> –HsfA1– <i>AOC1</i> module mediates heat priming–enhanced blast resistance in rice
As global climate change exacerbates extreme heat events, the interplay between heat stress and blast disease resistance in rice remains poorly understood. In this study, through integrated transcript...
Inflammation awakens dormant cancer cells by modulating the epithelial–mesenchymal phenotypic state
The awakening of dormant disseminated cancer cells appears to be responsible for the clinical relapses of patients whose primary tumors have been successfully cured months and even years earlier. In t...
Resurfacing promotes antibacterial activity of a lipid A–binding nanobody
Nanobodies have been pursued as candidates for antimicrobial design due to their small size and versatile binding capacities, but direct antibacterial activity of a nanobody has yet to be described. H...