Proceedings of the National Academy of Sciences
Articles in this Issue
Improving cell-free metabolism through direct integration of artificial respiratory chains
Energy-conserving mechanisms are essential in supporting cellular life. Yet in synthetic biology, it remains a challenge to reconstruct such processes from the bottom–up and integrate them with other...
Beyond native sequence recovery: Improved modeling of the sequence-energy landscape of protein structures
Computational protein design using machine learning models has advanced rapidly since the introduction of AlphaFold2. There is now a suite of tools that enable in silico design of proteins with desire...
TMED9 drives non-small-cell lung cancer progression via promotion of autophagy by recruiting USP5 to deubiquitinate ATG9A
Non-small-cell lung cancer (NSCLC), the predominant type of lung cancer, is characterized by high invasiveness and significant mortality. Despite its clinical impact, the molecular mechanisms driving...
Tomographic imaging of superconducting order using particle–hole interference
Superconducting phases with exotic symmetries that differ from the underlying crystalline lattice are at the focus of superconductivity research. Yet, despite intense interest, detecting the order par...
Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir
HIV-1 cure requires preventing viral rebound after treatment interruption, but quantitative criteria defining the rebound-competent reservoir are lacking. We studied individuals undergoing observation...
Orientation-tuned surround suppression exhibits a unique laminar signature in the human primary visual cortex
Spatial context modifies visual perception by enhancing novel and salient features over spatially redundant features in the underlying neural code of the primary visual cortex (V1). Although multiple...
Meiotic cohesin Rec8 imposes fitness costs on fission yeast gametes favoring the evolution of parental bias in gene expression
Differences between partner gametes, which evolved repeatedly in eukaryotes, can contribute to the evolution of the sexes, sexual selection, and non-Mendelian inheritance. Yet, the empirical evidence...
Biomolecular assemblies through weak noncovalent interactions: Higher-order transient structures and their condensate phase
Recent data suggest that many membrane proteins spontaneously organize into spatial patterns through weak noncovalent interactions. These weak interactions are protein type-specific and underlie the f...
Analytical modeling for suction cup designs for skin-interfaced wearable devices
Stable mounting is a central requirement for skin-interfaced wearable biomedical devices, because accurate and long-term measurements with clinical utility typically demand intimate contact with the s...
Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics
During an outbreak, infectious disease can spread among populations through host movement, potentially fueling local outbreaks with their own epidemiological dynamics. However, it is difficult to know...
Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning
The spatial patterning of mammalian hair follicle precursors in embryonic skin is most commonly studied in the laboratory mouse ( Mus musculus ), where new foll...
Initial organization and progressive expansion of the math-responsive brain network during the first school years
The neural mechanisms by which the developing brain acquires higher mathematical concepts from elementary intuitions remain poorly understood. Through a large-scale longitudinal functional MRI study o...
Fatty acid regulation and phosphatidylethanolamine biosynthesis are important for hepatitis E virus replication
Hepatitis E virus (HEV), a leading cause of viral hepatitis globally, is associated with adverse outcomes during pregnancy. Despite its clinical significance, the mechanisms driving enhanced HEV repli...
Nitrogen–TOR targets a bivalent chromatin reader to modulate floral transition
Nitrogen is an essential nutrient vital for plant health and productivity. How plants integrate nutrient signals and epigenome dynamics to modulate transcription and developmental transition remains l...
The TaMYB55–TaSnRK1α1–TabZIP9 module confers heat stress tolerance in wheat
Heat stress poses a severe threat to global crop yields and food security. Here, we demonstrate that TaSnRK1α1, the α-catalytic subunit of sucrose non-fermenting-1-related kinase 1, serves as a pivota...
Granulosa cell glycogen fuels the avascular corpus luteum
The corpus luteum (CL) arises from the luteinization of granulosa cells (GCs) and theca cells, marked by rapid progesterone elevation and angiogenesis. Intriguingly, angiogenesis lags behind progester...
Superstatistics approach to turbulent circulation fluctuations
Recent investigations of turbulent circulation fluctuations have uncovered substantial insights into the statistical organization of flow structures and revealed unexpected geometric features of turbu...
Pierre Chambon, a pioneer of molecular biology and gene regulation in eukaryotes
The scientific world has lost one of its great architects with the passing of Pierre Chambon, a visionary French scientist, institution builder, and demanding yet inspiring mentor. He provided major i...
A molecular timescale for evolution of cobamide biosynthesis
Cobamides are essential nutrients for most organisms but are only biosynthesized by a limited number of taxa through aerobic and anaerobic pathways. Although the origin of these widespread shared cofa...
Early warning signals for loss of control in complex systems
Maintaining stability in feedback systems, from aircraft and autonomous robots to biological and physiological systems, relies on monitoring their behavior and continuously adjusting their inputs. Inc...
Pressure-induced softening of locust bean gum hydrogels: A counterintuitive alternative to freeze–thaw stiffening
Hydrogels have been widely used in biomedical and environmental applications, yet precise control of mechanical properties (quantified by elastic modulus, G′) over a broad range remains essential for...
Correlating picosecond electron transfer and confined water dynamics in Prussian Blue using electrochemical two-dimensional infrared spectroscopy
Prussian Blue is not only the oldest synthetic pigment, but also an electrochemically active material with modern technological relevance for its electrochromic properties and applications in energy s...
Intrabubble coupled evolution of microdroplets and nanobubbles in oxygen evolution reaction
In the oxygen evolution reaction (OER), adherent gas bubbles are conventionally viewed as a major impediment that blocks ion and mass transport by covering active sites. Here, we show that for ionomer...
A human lysosomal storage disorder toolkit for decoding proteome landscapes in cortical-like and dopaminergic-like induced neurons
Lysosomes maintain cellular homeostasis by degrading proteins delivered via endocytosis and autophagy and by recycling building blocks for organelle biogenesis. Lysosomal storage disorders (LSDs) comp...
Coordination of N <sub>2</sub> -fixing cell specialization and patterning in filamentous cyanobacteria by a uniquely structured σ factor
Cell differentiation and Turing-like patterning are tightly associated in a group of filamentous cyanobacteria that differentiate specialized N 2 -fixing cells,...