Proceedings of the National Academy of Sciences
Articles in this Issue
Correction for Zhu et al., Bioinspired nanogels as cell-free DNA trapping and scavenging organelles for rheumatoid arthritis treatment
Correction to Supporting Information for Guo et al., Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27–Retromer complex
AI protocol for retrieving protein dynamic structures from two-dimensional infrared spectra
Understanding the dynamic evolution of protein structures is crucial for uncovering their biological functions. Yet, real-time prediction of these dynamic structures remains a significant challenge. T...
Fast Interpretable Greedy-Tree Sums
Modern machine learning has achieved impressive prediction performance, but often sacrifices interpretability, a critical consideration in high-stakes domains such as medicine. In such settings, pract...
Bioinspired energy-free temperature gradient regulator for significant enhancement of thermoelectric conversion efficiency
Enhancing thermoelectric conversion efficiency (TCE) is pivotal for advancing global energy conservation and emission reduction initiatives. Traditional approaches primarily focus on microscopic strat...
Turbulent mixing controls fixation of growing antagonistic populations
Unlike coffee and cream that homogenize when stirred, growing micro-organisms (e.g., bacteria, baker’s yeast) can actively kill each other and avoid mixing. How do such antagonistic interactions impac...
Variable-strength nonlocal measurements reveal quantum violations of classical counting principles
We implement a variant of the quantum pigeonhole paradox thought experiment to study whether classical counting principles survive in the quantum domain. We observe strong measurements significantly v...
Self-assembled proteomimetic (SAP) with antibody-like binding from short PNA–peptide conjugates
Affinity proteins based on a three-helix bundle (affibodies, alphabodies, and computationally de novo designed ones) have been shown to be a general platform to discover binders with properties remini...
A method for unsupervised learning of coherent spatiotemporal patterns in multiscale data
The unsupervised and principled diagnosis of multiscale data is a fundamental obstacle in modern scientific problems from, for instance, weather and climate prediction, neurology, epidemiology, and tu...
Superfluid weight cross-over and critical temperature enhancement in singular flat bands
Nonanalytic Bloch eigenstates at isolated band degeneracy points exhibit singular behavior in the quantum metric. Here, a description of superfluid weight for zero-energy flat bands in proximity to ot...
Detrimental influence of Arginase-1 in infiltrating macrophages on poststroke functional recovery and inflammatory milieu
Poststroke inflammation critically influences functional outcomes following ischemic stroke. Arginase-1 (Arg1) is considered a marker for anti-inflammatory macrophages, associated with the resolution...
Receptor clustering tunes and sharpens the selectivity of multivalent binding
The immune system exploits a wide range of strategies to combine sensitivity with selectivity for optimal response. We propose a generic physical mechanism that allows tuning the location and steepnes...
Hidden complexity of α7 nicotinic acetylcholine receptor desensitization revealed by MD simulations and Markov state modeling
The α7 nicotinic acetylcholine receptor is a pentameric ligand-gated ion channel that plays an important role in neuronal signaling throughout the nervous system. Its implication in neurological disor...
A clinically relevant model and method to study necrosis as a driving force in glioma restructuring and progression
All glioblastoma (GBM) molecular subsets share the common trait of accelerated progression following necrosis, which cannot be adequately explained by cellular proliferation arising from accumulated g...
Identification of a protective antigen reveals the trade-off between iron acquisition and antigen exposure in a global fungal pathogen
Systemic infections caused by Cryptococcus claim over 161,000 lives annually, with global mortality rate close to 70% despite antifungal therapies. Currently, n...
Interconnecting fragmented forests: Small and mobile birds are cornerstones in the plant–frugivore meta-network
Habitat fragmentation is causing the collapse of seed dispersal interactions and ecosystem functioning. When management and conservation strategies aim to sustain ecosystem functioning of fragmented f...
SNORD80-guided 2’-O-methylation stabilizes the lncRNA GAS5 to regulate cellular stress responses
The introns of the gene encoding the long noncoding RNA (lncRNA) GAS5 host up to 10 C/D box small nucleolar RNAs (snoRNAs). However, whether there is a regulatory and functional relationship between t...
Raver1 links <i>Ripk1</i> RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance
Multiple cell death and inflammatory signaling pathways converge on two critical factors: receptor-interacting serine/threonine kinase 1 (RIPK1) and caspase-8. Careful regulation of these molecules is...
Photopic flicker optoretinography captures the light-driven length modulation of photoreceptors during phototransduction
In this study, we used an inhibitor of phosphodiesterase 6 (PDE6) to examine the impact of changes in the conformation of the PDE6 protein on the light-induced process responsible for altering the len...
Metabolomic insights into pathogenesis and therapeutic potential in adult acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) poses challenges in adult patients, considering its heterogeneous nature and often suboptimal treatment outcomes. Here, we performed a study on 201 newly diagnosed a...
The MutRS quorum-sensing system controls lantibiotic mutacin production in the human pathogen <i>Streptococcus mutans</i>
Microbes use quorum-sensing systems to respond to ecological and environmental changes. In the oral microbiome, the pathogenic bacterium Streptococcus mutans us...
Photoreceptor-induced LHL4 protects the photosystem II monomer in <i>Chlamydomonas reinhardtii</i>
Photosynthesis, the fundamental process using light energy to convert carbon dioxide to organic matter, is vital for life on Earth. It relies on capturing light through light-harvesting complexes (LHC...
Spatial profiling of the interplay between cell type- and vision-dependent transcriptomic programs in the visual cortex
How early sensory experience during “critical periods” of postnatal life affects the organization of the mammalian neocortex at the resolution of neuronal cell types is poorly understood. We previousl...
Spatial population dynamics of bacterial colonies with social antibiotic resistance
Bacteria frequently inhabit surface-attached communities where rich “social” interactions can significantly alter their population-level behavior, including their response to antibiotics. Understandin...
The antimicrobial activity of ETD151 defensin is dictated by the presence of glycosphingolipids in the targeted organisms
Fungal infections represent a significant global health concern, with a growing prevalence of antifungal drug resistance. Targeting glucosylceramides (GlcCer), which are functionally important glycosp...