Proceedings of the National Academy of Sciences
Articles in this Issue
Environmental resistome–guided development of resistance-tolerant antibiotics
Failure to anticipate new forms of antibiotic resistance has led to resistance developing rapidly to virtually all antibiotics that have entered clinical use. Many of the most problematic types of res...
Reply to Tauzin: How to implement novelty in theory of mind tasks
Reply to Füller et al.: Exome-wide genetic associations with socioeconomic status and their pleiotropy among health outcomes
Communicative mentalization is limited in nonhuman great apes
Genetic associations with socioeconomic status are limited in explaining the socioeconomic health gradient
Energetics and evolutionary fitness
It has long been recognized that energy is the currency of evolution, but contrasting conceptions of the relationship between energy and adaptation have yielded different interpretations. In the equal...
Flamingos use their L-shaped beak and morphing feet to induce vortical traps for prey capture
Flamingos feature one of the most sophisticated filter-feeding systems among birds, characterized by upside-down feeding, comb-like lamellae, and a piston-like tongue. However, the hydrodynamic functi...
Ultraviolet and biological effective dose observations at Gale Crater, Mars
The incident ultraviolet (UV) irradiance on the surface of Mars is strongly sterilizing and plays a critical role in atmospheric and near-surface photochemistry. The Rover Environmental Monitoring Sta...
Phase separation in mitochondrial fate and mitochondrial diseases
Mitochondria are central metabolic organelles that control cell fate and the development of mitochondrial diseases. Traditionally, phase separation directly regulates cell functions by driving RNA, pr...
HCK regulates NLRP12-mediated PANoptosis
NOD-like receptors (NLRs) are a highly conserved family of cytosolic pattern recognition receptors that drive innate immune responses against pathogens, pathogen-associated molecular patterns, damage-...
Neuron–astrocyte associative memory
Astrocytes, the most abundant type of glial cell, play a fundamental role in memory. Despite most hippocampal synapses being contacted by an astrocyte, there are no current theories that explain how n...
Autophagy-mediated downregulation of AXL and TIM-1 promotes sustained Zika virus infection
Zika virus (ZIKV) infection can lead to a variety of clinical outcomes, including severe congenital abnormalities. The phosphatidylserine receptors AXL and TIM-1 are recognized as critical entry facto...
Learning to estimate sample-specific transcriptional networks for 7,000 tumors
Cancers are shaped by somatic mutations, microenvironment, and patient background, each altering gene expression and regulation in complex ways, resulting in heterogeneous cellular states and dynamics...
The cortical critical power law balances energy and information in an optimal fashion
A recent study has suggested that the stimulus responses of cortical neural populations follow a critical power law. More precisely, the power spectrum of the covariance matrix of neural responses fol...
Correction for Fernandez Velasco et al., Expert navigators deploy rational complexity–based decision precaching for large-scale real-world planning
The distribution of highly deleterious variants across human ancestry groups
A major focus of human genetics is to map severe disease mutations. Increasingly, that goal is understood as requiring huge numbers of people to be sequenced from every broadly defined genetic ancestr...
BRD9 functions as an HIV-1 latency regulatory factor
A major challenge for HIV type 1 (HIV-1) cure is the presence of viral latent reservoirs. The “Shock & Kill” strategy involves the combined use of latency reversal agents (LRA) and antiretroviral...
Dinucleotide preferences underlie apparent codon preference reversals in the <i>Drosophila melanogaster</i> lineage
We employ fine-scale population genetic analyses to reveal dynamics among interacting forces that act at synonymous sites and introns among closely related Drosophila...
Horizontal transmission of functionally diverse transposons is a major source of new introns
Since the discovery of spliceosomal introns in eukaryotic genomes, the proximate molecular and evolutionary processes that generate new introns have remained a critical mystery. Specialized transposab...
Experimental and theoretical evidence of universality in superfluid vortex reconnections
The minimum separation between reconnecting vortices in fluids and superfluids obeys a universal scaling law with respect to time. The prereconnection and the postreconnection prefactors of this scali...
Multiparametric functional characterization of individual lipid nanoparticles using surface-sensitive light-scattering microscopy
The most efficient lipid nanoparticles (LNPs) for gene therapeutics rely on specific lipids that protect the oligonucleotide cargo and aid cellular uptake and subsequent endosomal escape. Yet, the eff...
The white lupin CCR1 receptor-like kinase controls systemic Autoregulation of Cluster Root and Nodule Development
Root development is tightly regulated in plants to optimize nutrient acquisition and interactions with soil microorganisms. In legumes, the Autoregulation of Nodulation (AoN) pathway systemically cont...
Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation
Liver metastasis remains the predominant cause of mortality in patients with colorectal cancer (CRC). Nevertheless, the mechanisms underlying the initiation of colorectal cancer liver metastasis remai...
Correction for Masliah et al., β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer’s disease and Parkinson’s disease
Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles
Broad immune responses are needed to mitigate viral evolution and escape. To induce antibodies against conserved receptor-binding domain (RBD) regions of SARS-like betacoronavirus (sarbecovirus) spike...