Proceedings of the National Academy of Sciences
Articles in this Issue
Correction for Johnson et al., Comparing integrative ventilatory and renal acid–base acclimatization in lowlanders and Tibetan highlanders during ascent to 4,300 m
Enhanced polymorph metastability drives glycine nucleation in aqueous salt solutions
A continental view of climate effects on lakes
Correction for Epstein-Barash et al., Prolonged duration local anesthesia with minimal toxicity
Host ZAP activity correlates with the levels of CpG suppression in primate lentiviruses
Zinc-finger antiviral protein (ZAP) is thought to drive the suppression of CpG dinucleotides in many viruses to mimic the composition of their host genomes. However, in vivo evidence is sparse. Here,...
Phosphatic stromatoporoid sponges formed reefs ~480 Mya
Stromatoporoid sponges were important reef-builders during the middle Paleozoic, yet their early history and integration into reef ecosystems remain poorly understood. Here, we report...
Enamel–dentine junction morphology reveals population replacement and mobility in the late prehistoric Middle Nile Valley
Transitions from foraging to food-production represent a worldwide turning point in recent human history. In the Middle Nile Valley this cultural shift occurred between the sixth and beginning of the...
Correction for Kumar et al., Cluster dynamical mean-field study of intra-unit-cell charge nematicity in hole-doped cuprates
Correction for Wijnakker et al., Integrin-activating <i>Yersinia</i> protein Invasin sustains long-term expansion of primary epithelial cells as 2D organoid sheets
Epistasis-mediated compensatory evolution in a fitness landscape with adaptational tradeoffs
The evolutionary adaptation of an organism to a stressful environment often comes at the cost of reduced fitness. For example, resistance to antimicrobial drugs frequently reduces growth rate in the d...
Bourbon and Mycbp function with Otu to promote Sxl protein expression in the <i>Drosophila</i> female germline
In Drosophila ovaries, germ cells differentiate through several stages of cyst development before entering meiosis. This early differentiation program depends o...
Global subnational estimates of migration of scientists reveal large disparities in internal and international flows
Researchers are key contributors to innovation. Their migration results in talent circulation and recombination of ideas. Due to data shortage, little is known about subnational mobility of scientists...
Unsupervised learning of structural relaxation in supercooled liquids from short-term fluctuations
Unraveling the relationship between structural information and the dynamic properties of supercooled liquids is one of the great challenges of physics. Dynamic heterogeneity, characterized by the prop...
Structural basis of ZP2-targeted female nonhormonal contraception
Monoclonal antibody IE-3 prevents mouse fertilization by binding ZP2, a major component of the oocyte-specific zona pellucida (ZP). We show that an IE-3-derived single-chain variable fragment (scFV) i...
DprA recruits ComM to facilitate recombination during natural transformation in Gram-negative bacteria
Natural transformation (NT) represents one of the major modes of horizontal gene transfer in bacterial species. During NT, cells can take up free DNA from the environment and integrate it into their g...
Interactions among nutrients govern the global grassland biomass–precipitation relationship
Ecosystems are experiencing changing global patterns of mean annual precipitation (MAP) and enrichment with multiple nutrients that potentially colimit plant biomass production. In grasslands, mean ab...
Privacy for free in the overparameterized regime
Differentially private gradient descent (DP-GD) is a popular algorithm to train deep learning models with provable guarantees on the privacy of the training data. In the last decade, the problem of un...
Melting of nonreciprocal solids: How dislocations propel and fission in flowing crystals
When soft matter is driven out of equilibrium its constituents interact via effective interactions that escape Newton’s action–reaction principle. Prominent examples include the hydrodynamic interacti...
FAO-fueled OXPHOS and NRF2-mediated stress resilience in MICs drive lymph node metastasis
Metastasis is an inefficient process requiring cancer cells to adapt metabolically for survival and colonization in new environments. The contributions of tumor metabolic reprogramming to lymph node (...
Self-organized institutions in evolutionary dynamical-systems games
Social institutions are systems of shared norms and rules that regulate people’s behaviors, often emerging without external enforcement. They provide criteria to distinguish cooperation from defection...
ID3 enhances PD-L1 expression by restructuring MYC to promote colorectal cancer immune evasion
The inhibitor of DNA binding protein ID3 has been associated with the progression of colorectal cancer (CRC). Despite its significance, its specific role in the immune evasion strategies utilized by C...
On Hodge polynomials for nonalgebraic complex manifolds
Hodge theory is pivotal in studying algebraic varieties’ intricate geometry and topology: it provides essential insights into their structure. The Hodge decomposition theorem establishes a profound li...
<i>SRP19</i> and the protein secretion machinery is a targetable vulnerability in cancers with <i>APC</i> loss
Loss of the tumor suppressor gene (TSG) Adenomatous Polyposis Coli ( APC ) is a hallmark event in colorectal cancers. Since it is not possible to directly targe...
A computational analysis of lexical elaboration across languages
Claims about lexical elaboration (e.g. Mongolian has many horse-related terms) are widespread in the scholarly and popular literature. Here, we show that computational analyses of bilingual dictionari...
Proximity-activated DNA scanning encoded sequencing for massive access to membrane proteins nanoscale organization
Cellular structure maintenance and function regulation critically depend on the composition and spatial distribution of numerous membrane proteins. However, current methods face limitations in spatial...