Proceedings of the National Academy of Sciences
Articles in this Issue
Differential <i>Hes1</i> activation defines neural stem cell lineage commitment and niche maintenance in embryonic and adult mouse cortex
Mode of Hes1 activation and its differential expression are crucial for the maintenance of neural stem cells/progenitor cells (NSCs/NPCs) in the embryonic corte...
Correction for Tian et al., DNA polymerase delta governs parental histone transfer to DNA replication lagging strand
Post-encoding administration of oxytocin selectively enhances memory consolidation of male faces in females
Oxytocin plays a critical role in modulating social cognition and enhancing human memory for faces. However, it remains unclear which phase of memory oxytocin affects to enhance face memory. Our study...
Mangrove restoration and coastal flood adaptation: A global perspective on the potential for hybrid coastal defenses
To reduce current and future coastal flood risk, it is critical to better understand how adaptation measures, including nature-based solutions, can reduce that risk. Globally, hybrid coastal defenses,...
Ubiquitination of BAM1 attenuates CLE peptide–mediated signaling in the root apical meristem
The plasma membrane-resident receptor-like kinases (RLKs) and their cognate peptide ligands play crucial roles in plant growth and development. The RLK BARELY ANY MERISTEM1 (BAM1) promotes phloem form...
Coral reef fish may be more important than we thought
Polar vortex dynamics on gas giants: Insights from 2D energy cascades
The distinct polar vortex dynamics observed on Jupiter and Saturn may provide insights into their interiors. In this study, we examine how the number and structure of polar vortices vary with forcing...
Functionally heterogeneous intratumoral CD4 <sup>+</sup> CD8 <sup>+</sup> double-positive T cells can give rise to single-positive T cells
Conventional single-positive (SP) CD4 + and CD8 + T cells recognize tumor antigens and help mediate clinical responses w...
Sleep loss induces cholesterol-associated myelin dysfunction
The increasing prevalence of sleep deprivation poses a public health challenge in modern society. Manifestations of reduced alertness, such as slowed reaction times and increased errors, are well-docu...
Soft giant magnetoimpedance electronics enable contact-free human–machine interactions
Magnetic sensing enables contact-free, three-dimensional human–machine interactions (HMI) with high selectivity and resilience to environmental noise. However, conventional magnetic films, mostly obta...
Real-time spatiotemporal tracking of infectious outbreaks in confined environments with a host–pathogen agent-based system
Deadly infection outbreaks in confined spaces, whether it is a COVID-19 outbreak on a cruise ship or measles and stomach flu outbreaks in schools, can be characterized by their rapid spread due to the...
No deep insights into the alignment between human and deep learning reasoning processes: Thoughts on de Varda et al. (2025)
Conservation should assume realistic adaptive capacities
Conservation actions often assume implicitly that heritabilities are zero and that threatened populations cannot adapt to changing environments. To illustrate, we evaluated the last 10 y of recovery p...
A neural circuit basis for reward-induced suppression of fear generalization and enhancement of fear extinction
How positive and negative affective stimuli interact in the brain to influence behavioral outcomes remains poorly understood. Here, we show that recall of a positively valenced reward-associated cue (...
Beyond species ranges: How functional diversity and integrated life history can inform conservation priorities
ER membrane receptors engage core autophagy machinery to initiate ER-phagy
Endoplasmic reticulum (ER) phagy is the form of selective autophagy that governs ER abundance and integrity by targeting dysfunctional ER fragments for degradation. How the recognition of ER fragments...
Dynamic regulation of receptor-modulated endothelial NADPH oxidases
The stable reactive oxygen species (ROS) hydrogen peroxide (H 2 O 2 ) acts as a key signaling molecule for many vital in...
Reply to Dujmović: The alignment in cost between human and model reasoning is an empirical phenomenon worth explaining
Human-induced biospheric carbon sink: Impact from the Taklamakan Afforestation Project
The Taklamakan Desert, one of the world’s largest and driest deserts, has traditionally been considered a biological void. Here, we demonstrate that large-scale ecological restoration is transforming...
BORC assemblies integrate BLOC-1 subunits to diversify endosomal trafficking functions
BORC and BLOC-1 are multisubunit complexes that regulate endolysosomal trafficking. Although they are presumed to be distinct, their paralogous origins and shared subunits suggest the potential for hi...
Human action shapes the beaks of backyard birds
Calumenin prevents fibroblast senescence and lung aging by promoting vimentin proteostasis
Progressive lung fibrosis is linked to aging-related dysfunction in fibroblasts, which remains poorly understood. To investigate the alterations in fibroblasts, particularly the molecular programs dri...
Constraints on the impactor flux to the Earth–Moon system from oxygen isotopes of the lunar regolith
The impactor flux record to Earth has largely been erased by active tectonics, weathering, and continual reworking of the crust. Instead, a record of highly siderophile elements (HSE: Re, Os, Ir, Ru,...
How much of the forest sink is passive? Case of the United States
Over time, carbon sequestered in temperate forests has increased, but the relative effects of passive and active drivers remain unclear. This study uses plot-level data to disentangle the contribution...
Scaling the glassy dynamics of active particles: Tunable fragility and reentrance
Understanding the influence of activity on dense amorphous assemblies is crucial for biological processes such as wound healing, embryogenesis, or cancer progression. Here, we study the effect of self...