Proceedings of the National Academy of Sciences
Articles in this Issue
A molecular tango between chromatin and metabolites orchestrates a feedback switch for alcohol consumption
An agenda for science communication research and practice
Science should not unilaterally dictate individuals’ decisions or public policies. Yet, it provides a vital source of information for societies and individuals that can often improve outcomes and well...
The earliest domestic pigs in Neolithic China were closely managed
In silico evolution of globular protein folds from random sequences
The origin and evolution of protein folds are among the most challenging, long-standing problems in biology. We developed Protein Fold Evolution Simulator (PFES), a computational approach that simulat...
Action-mode subnetworks for decision-making, action control, and feedback
The action-mode network (AMN) is a canonical functional brain network first identified using resting-state functional connectivity (RSFC). Based on animal and human data, we have proposed that AMN sup...
Correction for Hoshikawa et al., Formation of giant ER sheets by pentadecanoic acid causes lipotoxicity in fission yeast
Singularity formation in 3D Euler equations with smooth initial data and boundary
A long-standing fundamental open problem in mathematical fluid dynamics and nonlinear partial differential equations is to determine whether solutions of the 3D incompressible Euler equations can deve...
Onset of extensive human fire use 50,000 y ago
Fire is a pivotal aspect of human involvement in the carbon cycle. However, the precise timing of the large-scale human fire use remains uncertain. Here, we report a pyrogenic carbon record of East As...
Fertile androgenetic mice generated by targeted epigenetic editing of imprinting control regions
Each new mammalian life begins with the fusion of an oocyte and a sperm to produce a fertilized egg containing two sets of genomes, one from the mother and one from the father. Androgenesis, a way for...
Not only self-views but also any ratings converge without conversations due to reduced noise bias
Reply to Izuma and Kakinuma: Conversation aligns self-views above and beyond noise reduction
Downward movement of nitrate stimulates losses of soil organic carbon in deeper soil layers
A degradable form of polyoma small T antigen reveals the high specificity of TAZ in regulating gene expression
The study of DNA tumor viruses has revolutionized cancer biology, partly by virtue of the unique capabilities of viral oncoproteins to manipulate key proteins and pathways involved in tumorigenesis. W...
Reply to Ju et al.: Mechanisms of deeper soil organic carbon loss
Tandem ssDNA in neutrophil extracellular traps binds thrombin and regulates immunothrombosis
Neutrophils release neutrophil extracellular traps (NETs) to neutralize infections, a process that also contributes to immunothrombosis. While beneficial in localized infections, excessive NET formati...
The global persistence of work from home
Work from home (WFH) surged worldwide during the COVID-19 pandemic, then partially receded as the pandemic subsided. Using our Global Survey of Working Arrangements covering dozens of countries, we fi...
SpecTf: Transformers enable data-driven imaging spectroscopy cloud detection
Current and upcoming generations of visible-shortwave infrared (VSWIR) imaging spectrometers promise unprecedented capacity to quantify Earth system processes across the globe. However, reliable cloud...
Detecting environmentally dependent developmental plasticity in fossilized individuals
The fossil record provides the most powerful evidence of large-scale biodiversity change on Earth, but it does so at coarse and often idiosyncratic temporal scales. One critical problem that arises co...
Building confidence in models for complex barrier systems for radionuclides
The modeling and simulation of the Cement–clay Interaction–Diffusion field (CI-D) experiment at the Mont Terri site in Switzerland presented here demonstrates that it is possible to capture the multis...
Polymer sailing on rafts within lipid membranes
Understanding the dynamics of macromolecules adsorbed from extracellular fluids onto cell membranes is crucial for elucidating basic cellular processes and advancing applications in biotechnology, suc...
The transcription factor Bcl11a is essential for B-1a cell maintenance during aging
B-1a cells, a self-renewing B cell subset essential for innate immunity, produce natural IgM antibodies that defend against pathogens, yet mechanisms sustaining their maintenance during aging remain u...
TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway
TEAD proteins are the main transcriptional effectors of the Hippo signaling pathway and a clinical-stage pharmacological target in oncology. Most TEAD-targeting small molecules are designed to disrupt...
Regulation of the ordinal DNA translocation cycle in bacteriophage Φ29 through trans-subunit interactions
Certain viruses such as tailed bacteriophages and herpes simplex virus package double-stranded DNA into empty procapsids via powerful, ring-shaped molecular motors. High-resolution structures and forc...
Disentangling temperature and Reynolds number effects in quantum turbulence
The interplay between viscous and frictional dissipation is key to understanding quantum turbulence dynamics in superfluid 4 He. Based on a coarse-grained two-f...
PI(4)P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis
Lipid droplets (LDs) are evolutionarily conserved organelles that play important roles in metabolism. Each LD is enclosed by a monolayer of phospholipids, distinct from bilayer membranes. The composit...