Proceedings of the National Academy of Sciences
Articles in this Issue
Mapping ammonia emission plumes using shortwave infrared imaging spectroscopy
Atmospheric ammonia emissions are harmful to ecosystems and human health. These emissions have traditionally been monitored using thermal infrared spectrometers, though such techniques are limited by...
Phosphoproteome-derived peptide libraries for deep specificity profiling of phosphatases and phospholyases
Protein phosphorylation is dynamically regulated by the opposing activities of phosphowriter enzymes (kinases) and phosphoeraser enzymes (phosphatases and phospholyases). While significant progress ha...
Experimental evolution of cellular miniaturization reveals a putative mechanism for cell size evolution
Cell volume, a key determinant of physiology, is maintained by cell size homeostasis. Large deviations from typical size are often harmful, yet cell sizes have diverged drastically during evolution. H...
Heterotypic intercellular adhesion tunes efficiency of cell-on-cell migration
Cell migration across epithelial barriers occurs in diverse developmental, immunological, and pathological contexts. Here, we investigate the contribution of heterotypic adhesion between migrating cel...
Correction for Ajourlou et al., Upper mantle temperatures illuminate the Iceland hotspot track and understanding of ice–Earth interactions in Greenland
LARP1 integrates MYC and mTOR signaling to enable anabolic growth during tumor initiation
Tumor initiation requires the integration of oncogenic signals with environmental cues to enable anabolic growth. MYC is central to tumorigenesis, with its deregulation observed in over 60% of human c...
Conceptual priorities shape individual gaze patterns during naturalistic visual attention
Our visual landscape consists of not only people, places, and objects (e.g., “soldier,” “stadium,” “flag”) but also the conceptual relationships that unite them (e.g., “patriotism”). Because conceptua...
Transformations of the spatial activity manifold convey aversive information in CA3
Hippocampal circuits form cognitive maps that represent spatial position and integrate contextual information, including affective cues, into episodic memory representations. We investigated how spati...
A protective role for APP in nuclear waste clearance via lysosomal exocytosis
Amyloid precursor protein (APP) is widely known for its role in Alzheimer’s disease (AD) pathogenesis through its proteolytic processing into amyloid-β peptides. However, its physiological functions r...
Subcellular metallomic networks orchestrate physiological outcomes: Single-cell mapping via an integrated SEM-FIB-TOF-SIMS platform
The spatial organization of essential, nonessential, and toxic metal(loid) elements (MEs) within plant cells underpins physiological function. Yet, comprehensive subcellular imaging of the full ME spe...
Glycosylation-independent functions for distinct glypican core proteins drive cell-specific responses in corticogenesis
The extracellular matrix plays critical roles in orchestrating cell communication and behaviors in response to various extracellular signals. It is a complex network composed of proteins and polysacch...
Strain-specific propagation of variant Creutzfeldt–Jakob disease prions in humanized neural cells
Prions are self-templating assemblies of the host prion protein in which conformational templating encodes heritable “strain” information. Human prion diseases, including Creutzfeldt–Jakob disease (CJ...
Development of a robust method to derive human trophoblast stem cells from late-gestation placentas and its application to preeclampsia
Trophoblasts are multifunctional cells in the placenta and essential for normal pregnancy. Although trophoblast dysfunction can cause pregnancy complications, the underlying mechanisms remain unclear,...
Phase-selective Floquet engineering in a charge density wave material
Floquet engineering has emerged as a powerful approach for dynamically tailoring the electronic structures of quantum materials through time-periodic light fields. The light fields generated by ultraf...
Testicular origin of epigenetic inheritance independent of sperm mitochondrial DNA and epididymal exposure
Paternal epigenetic inheritance remains mechanistically unresolved. Recent studies propose that environmental exposures induce mitochondrial DNA (mtDNA)-dependent transcription in sperm during epididy...
Dark diversity framework reconciles Darwin’s naturalization conundrum for freshwater fish invasions
The spread of invasive species poses a major threat to global biodiversity, yet predicting successful establishment of exotic species in novel environments remains challenging. Darwin’s naturalization...
Disruption to TFEB signaling and autophagy in newly formed oligodendrocytes leads to aberrant generation of CNS myelin
Myelin is a defining feature of the vertebrate nervous system, yet the cellular and molecular mechanisms governing its integrity remain poorly understood. Here, using volume electron microscopy and a...
Drp1-driven fragmentation of scleral mitochondria promotes myopia development
The global epidemic of myopia constitutes a growing public health concern worldwide. Myopia development is characterized by pathological scleral remodeling through fibroblast-myofibroblast transdiffer...
The autophagy protein ATG-9 promotes aversive learning in <i>Caenorhabditis elegans</i> through trafficking neuropeptide receptors
Autophagy is a degradative process that maintains cellular homeostasis. Autophagy biogenesis occurs at synapses, but its impact on synaptic functions is incompletely understood. Here we show that, in...
IL-4 peptide hydrogel reprograms MSC heterogeneity toward the CD106+ population for enhanced renal repair
Mesenchymal stem cells (MSCs) exhibit significant heterogeneity, which limits their therapeutic efficacy in regenerative medicine. Here, we introduce a self-assembled interleukin-4 (IL-4) peptide hydr...
A gustatory receptor–Akt axis couples nutrient sensing to hematopoiesis in the silkworm
Hematopoiesis is tightly linked to an organism’s metabolic state, yet the molecular sensors that convert nutrient availability into hematopoietic output remain poorly understood. Here, we identify a f...
Differential Wnt/β-catenin signaling via TCF7L2/LEF1 binding specificity shapes cellular and tumor phenotypes
The mechanisms by which Wnt/β-catenin signaling regulates gene expression in a tissue- and context-specific manner remain poorly understood, limiting our ability to target the aberrant cell growth typ...
Expression of four mitochondrial tRNAs from only two loci
Transfer RNAs (tRNAs) are among the few genes retained in animal mitochondrial genomes after more than a billion years of gene loss. These ancient bacterial vestiges are often structurally aberrant an...
GREM1/FGFR1-activated myofibroblasts induce immunosuppression and accelerate metastasis in high-grade serous ovarian cancer
Joint effect of cancer-associated fibroblasts (CAFs) and regulatory T cells (Tregs) can drive immunosuppression in high-grade serous ovarian cancer (HGSOC), thereby promoting tumor metastasis and limi...
Social immunity can be a consequence and cause of social evolution
Many social insects respond to pathogens in ways that reduce pathogen transmission within their social groups, with behaviors such as grooming or removing infected individuals. This “social immunity”...