Proceedings of the National Academy of Sciences
Articles in this Issue
Bone microstructure supports a Mesozoic origin for a semiaquatic burrowing lifestyle in monotremes (Mammalia)
The platypus and four echidna species are the only living egg-laying mammals and the sole extant representatives of Order Monotremata. The platypus and echidnas are very disparate both morphologically...
Cryptic genetic variation in brain gene expression precedes the evolution of cannibalism in spadefoot toad tadpoles
The origins of novel behaviors are poorly understood, despite behavior’s hypothesized roles in evolution. One model, “genetic accommodation,” proposes that selection on ancestral phenotypic plasticity...
OGG1S326C variant frequent in human populations facilitates inflammatory responses due to its extended interaction with DNA substrate
8-oxoguanine (8-oxoGua) is one of the most frequent forms of oxidative DNA base lesions, repaired by 8-oxoguanine DNA glycosylase 1 (OGG1) via base excision repair (BER) pathway to maintain genome fid...
Impact of Mg <sup>2+</sup> and pH on amorphous calcium carbonate nanoparticle formation: Implications for biomineralization and ocean acidification
Crystallization by amorphous calcium carbonate (ACC) particle attachment (CPA) is a prevalent biomineralization mechanism among calcifying organisms. A narrow, controlled size distribution of ACC nano...
Architecture of <i>Pseudomonas aeruginosa</i> glutamyl-tRNA synthetase defines a subfamily of dimeric class Ib aminoacyl-tRNA synthetases
The aminoacyl-tRNA synthetases (AaRSs) are an ancient family of structurally diverse enzymes that are divided into two major classes. The functionalities of most AaRSs are inextricably linked to their...
Linked nitrogen and carbon dynamics reveal distinct pools and patterns in a deep, weathered bedrock rhizosphere
Nitrogen is one of the most limiting nutrients to forest productivity worldwide. Recently, it has been established that diverse ecosystems source a substantial fraction of their water from weathered b...
Inheritance of extraordinary metabolic activity from parental bacteria individuals
Many phenotypic traits, such as fermentation activity, have been shown to be instable due to stochastic gene expression and environmental influence. While previous studies only have obtained understan...
Structure of the human TWIK-2 potassium channel and its inhibition by pimozide
The potassium channel TWIK-2 is crucial for ATP-induced activation of the NLRP3 inflammasome in macrophages. The channel is a member of the two-pore domain potassium (K2P) channel superfamily and an e...
Nonequilibrium relaxation exponentially delays the onset of quantum diffusion
Predicting the exact many-body quantum dynamics of polarons in materials with strong carrier–phonon interactions presents a fundamental challenge, often necessitating one to adopt approximations that...
Social dominance in rats is a determinant of susceptibility to stress
Establishing a dominance hierarchy in social organisms is important for access to resources. Stress has been proposed as a major factor influencing an animal’s likely position in a social hierarchy. A...
Correction to Supporting Information for Jensen et al., Bcl2L13 is a ceramide synthase inhibitor in glioblastoma
Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine
RAS is the most frequently mutated oncogene in cancer. RAS proteins show high sequence similarities in their G-domains but are significantly different in their C-terminal hypervari...
The developmental factor TBX3 engages with the Wnt/β-catenin transcriptional complex in colorectal cancer to regulate metastasis genes
Wnt signaling orchestrates gene expression in a plethora of processes during development and adult cell homeostasis via the action of nuclear β-catenin. Yet, little is known about how β-catenin genera...
Derivational morphology reveals analogical generalization in large language models
What mechanisms underlie linguistic generalization in large language models (LLMs)? This question has attracted considerable attention, with most studies analyzing the extent to which the language ski...
Durably reducing partisan animosity through multiple scalable treatments
Recent research has identified several effective strategies for reducing Americans’ animosity toward supporters of opposing political parties. However, whether these strategies can durably reduce part...
Unbiased mechanical cloaks
The distinction between “reinforcement” and “cloaking” has been overlooked in optimization-based design of devices intended to conceal a defect in an elastic medium. In the former, a so-called “cloak”...
Acute chromatin decompaction stiffens the nucleus as revealed by nanopillar-induced nuclear deformation in cells
Chromatin architecture is critical in determining nuclear mechanics. Most studies focus on the mechanical rigidity conferred by chromatin condensation from densely packed heterochromatin, but less is...
Directional water navigation and reallocation in <i>Tillandsia capitata</i>
Liquid manipulation is ubiquitous in nature and engineering, enabling controllable and efficient liquid delivery. Conventional understanding of liquid manipulation relies on inhomogeneous chemical mod...
Differential elimination of marked sex chromosomes enables production of nontransgenic male mosquitoes in a single strain
Diverse genetic strategies are being pursued to control mosquito-borne infectious diseases. These strategies often rely on the release of nonbiting males to either reduce the target mosquito populatio...
Achievement (not effort) makes people feel entitled to rewards
It is common to say that people feel entitled to rewards—they think they have earned or deserve them—based on their effort and achievement. However, effort and achievement draw on different principles...
Ab initio stability predictions for rare earth oxyphosphates and experimental confirmation of cerium (III) phases
Rare earth oxyphosphates represent a large family of compounds with the general formula (RE 2 O 3 )...
Synergistic regulation of metal–organic cage architectures via temperature- and solvent-driven atropisomerism
Regulating multistimulus responses in artificial systems remains a challenge in smart material development. We present a versatile chemical switching system that precisely controls the self-assembly o...
VCP’s nuclear journey: Initiated by interacting with KPNB1 to repair DNA damage
DNA damage repair (DDR) is essential for cancer cell survival and treatment resistance, making it a critical target for tumor therapy. The eukaryotic AAA+ adenosine triphosphatase valosin-containing p...
Structural insights into the ubiquitin-independent midnolin-proteasome pathway
The protein midnolin (MIDN) augments proteasome activity in lymphocytes and dramatically facilitates the survival and proliferation of B-lymphoid malignancies. MIDN binds both to proteasomes and to su...
Coupling between electrons’ spin and proton transfer in chiral biological crystals
Proton transport plays a fundamental role in many biological and chemical systems. In life, proton transport is crucial for biochemical and physiological functions. It is usually accepted that the mai...