Proceedings of the National Academy of Sciences
Articles in this Issue
Counterfeit judgments in large language models
Modulation of the PGRMC1/NLRP7/HLA-C axis by autophagy is linked to both spontaneous preterm birth and gestational choriocarcinoma
Spontaneous preterm birth (SPTB) and gestational choriocarcinoma are both associated with complex physiological processes that significantly impact maternal health. While the molecular mechanisms unde...
Chromosomal deletions in banana somaclonal variants reveal negative regulators of immunity underlying <i>Fusarium</i> wilt resistance
Fusarium wilt, caused by Fusarium oxysporum f. sp. cubense tropical race 4 (TR4), poses a severe thr...
Modeling feasible locomotion of nanobots for cancer detection and treatment
Deploying motile nanosized particles, also known as “nanobots,” in the human body promises to improve selectivity in drug delivery and reduce side effects. We consider a swarm of nanobots locating a s...
Acoustic printing of conductive polymers
Fabricating materials within optically opaque structures, such as biological tissue, is a considerable challenge. Recently, ultrasound-based printing (“sonoprinting”) approaches have emerged as a prom...
Emergence of a contrast-invariant representation of naturalistic texture in macaque visual cortex
Sensory stimuli vary across a variety of dimensions, like contrast, orientation, or texture. The brain must rely on population representations to distinguish changes in one dimension from changes in a...
How social learning enhances—or undermines—efficiency and flexibility in collective decision-making under uncertainty
Balancing efficiency and flexibility in collective decision-making is increasingly critical in modern societies characterized by rapid sociocultural and technological change. Recent research in cognit...
Gray wolves in an anthropogenic context on a small island in prehistoric Scandinavia
Dogs were domesticated at least once from a yet-unidentified wolf population at least ~15,000 y ago. However, how domestication took place is a topic of ongoing debate, and the ability of human groups...
The near-infrared bacteriophytochrome-derived fluorescent protein PENELOPE enables RESOLFT superresolution microscopy
REversible Saturable Optical Linear Fluorescence Transitions (RESOLFT) superresolution microscopy fundamentally overcomes the diffraction barrier in far-field fluorescence microscopy. It relies on rev...
Migration and the persistence of violence
Using data on millions of internal US migrants, we document that historical homicide rates follow migrants around the United States. Individuals born in historically safe states remain safer wherever...
Impaired AIS plasticity in ankyrin-G mutant mice alters cortical excitability and behavior
The developing brain undergoes neuroplasticity driven by learning, experience, and memory formation. The axon initial segment (AIS) is a specialized membrane domain within the proximal axon that initi...
Correction for Bachellerie et al., Châtelperronian cultural diversity at its western limits: Shell beads and pigments from La Roche-à-Pierrot, Saint-Césaire
<i>Rroid2</i> regulates effector-to-memory CD8 <sup>+</sup> T cell differentiation during infection in vivo
CD8 + T cell differentiation has been associated with changes in the expression of long noncoding RNAs (lncRNAs). Yet, which and how lncRNAs regulate CD8...
Tropics-wide intraseasonal oscillations
The tropical climate variability is characterized by various oscillations across a range of timescales. Oscillations that imprint the tropical mean state are generally attributed to slow processes, su...
Stochastic responses and marginal valuation
The analysis of policy impacts in a dynamic and uncertain reality is vital to supporting informed economic policy design and implementation. Dynamic, stochastic economic models used in policy evaluati...
Correction for Tse et al., Large-scale combination screens reveal small-molecule sensitization of antibiotic-resistant gram-negative ESKAPE pathogens
From nematode to Nobel: How community-shared resources fueled the rise of <i>Caenorhabditis elegans</i> as a research organism
Experimental organisms such as the nematode Caenorhabditis elegans are fundamental to biological discovery. The success of C. elegans...
Genomic ancestry, behavior, and the domestication of the dog
Neural representation of the decisional reference point in monkeys
The decisional reference point serves as a hidden benchmark for evaluating options in decision-making. Despite extensive behavioral evidence for the existence of the reference point, its neural instan...
VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment
The trophectoderm (TE), the first lineage specified during mammalian development, initiates implantation and gives rise to placental trophoblasts. While animal models have elucidated key conserved sig...
A legacy of genetic entanglement with wolves shapes modern dogs
Dogs evolved through interactions between people and gray wolves during the Late Pleistocene and have been ubiquitous in human societies ever since. Instances of wolf-to-dog introgression are rare, bu...
Variability of annual polar motion and its relationship to the Chandler wobble
Given the large amplitude of prograde annual polar motion, we are able to quantify year-to-year variability of prograde annual excitation amplitude since pre-1900 observations. We obtain a Prograde An...
Understanding the strengths and limitations of community-based responses to misinformation
Genetic testing predicts appearance but not behavior in dogs
Genetic tests for behavioral and personality traits in dogs are now being marketed to pet owners, but their predictive accuracy has not been validated. To evaluate the reliability of such tests, we an...
Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging
Skeletal muscle is essential for movement, respiration, and metabolism, with mTORC1 acting as a key regulator of protein synthesis and degradation. In aging muscle, mTORC1 becomes overactivated, contr...