Proceedings of the National Academy of Sciences
Articles in this Issue
Correction for Austin et al., Death-receptor activation halts clathrin-dependent endocytosis
Correction for Khadim et al., Continental freshwater discharge influences sea surface salinity variability near world’s megadeltas
Correction for Thompson and Fronhofer, The conflict between adaptation and dispersal for maintaining biodiversity in changing environments
Correction to Supporting Information for Sutter et al., Electrochemical cofactor recycling of bacterial microcompartments
Correction for Zioga et al., Observed carbon decoupling of subnational production insufficient for net-zero goal by 2050
Lateral olivocochlear neurons modulate cochlear responses to noise exposure
The sense of hearing originates in the cochlea, which detects sounds across dynamic sensory environments. Like other peripheral organs, the cochlea is subjected to environmental insults, including lou...
A tough soft–hard interface in the human knee joint driven by multiscale toughening mechanisms
Joining heterogeneous materials in engineered structures remains a significant challenge due to stress concentration at interfaces, which often leads to unexpected failures. Investigating the complex,...
Antiviral Mx proteins have an ancient origin and widespread distribution among eukaryotes
Mx proteins, first identified in mammals, encode potent antiviral activity against a wide range of viruses. Mx proteins arose within the Dynamin superfamily of proteins (DSP), which mediate critical c...
Structure-guided engineering of a mutation-tolerant inhibitor peptide against variable SARS-CoV-2 spikes
Pathogen mutations present an inevitable and challenging problem for therapeutics and the development of mutation-tolerant anti-infective drugs to strengthen global health and combat evolving pathogen...
Life sets off a cascade of machines
Life is invasive, occupying all physically accessible scales, stretching between almost nothing (protons, electrons, and photons) and almost everything (the whole biosphere). Motivated by seventeenth-...
Lipid-induced condensate formation from the Alzheimer’s Aβ peptide triggers amyloid aggregation
The onset and development of Alzheimer’s disease is linked to the accumulation of pathological aggregates formed from the normally monomeric amyloid-β peptide within the central nervous system. These...
Co-option of mitochondrial nucleic acid–sensing pathways by HSV-1 UL12.5 for reactivation from latent infection
Although viruses subvert innate immune pathways for their replication, there is evidence they can also co-opt antiviral responses for their benefit. The ubiquitous human pathogen, Herpes simplex virus...
Life history is a key driver of temporal fluctuations in tropical tree abundances
The question of what mechanisms maintain tropical biodiversity is a critical frontier in ecology, intensified by the heightened risk of biodiversity loss faced in tropical regions. Ecological theory h...
Heterogeneous and multiple conformational transition pathways between pseudoknots of the SARS-CoV-2 frameshift element
Frameshifting is an essential mechanism employed by many viruses including coronaviruses to produce viral proteins from a compact RNA genome. It is facilitated by specific RNA folds in the frameshift...
Evidence that ARK2N is not a core factor in transcription-coupled DNA repair
Reply to van Schie et al.: ARK2N in TCR: Across in vivo and in vitro studies
Macromolecular interactions and geometrical confinement determine the 3D diffusion of ribosome-sized particles in live <i>Escherichia coli</i> cells
The crowded bacterial cytoplasm is composed of biomolecules that span several orders of magnitude in size and electrical charge. This complexity has been proposed as the source of the rich spatial org...
Automating alloy design and discovery with physics-aware multimodal multiagent AI
The design of new alloys is a multiscale problem that requires a holistic approach that involves retrieving relevant knowledge, applying advanced computational methods, conducting experimental validat...
Variants in the SOX9 transactivation middle domain induce axial skeleton dysplasia and scoliosis
SOX9 is a crucial transcriptional regulator of cartilage development and homeostasis. Dysregulation of SOX9 is associated with a wide spectrum of skeletal disor...
Diffusive topology preserving manifold distances for single-cell data analysis
Manifold learning techniques have emerged as crucial tools for uncovering latent patterns in high-dimensional single-cell data. However, most existing dimensionality reduction methods primarily rely o...
Representational geometry explains puzzling error distributions in behavioral tasks
Measuring and interpreting errors in behavioral tasks is critical for understanding cognition. Conventional wisdom assumes that encoding/decoding errors for continuous variables in behavioral tasks sh...
The <i>Pseudomonas</i> ligninolytic catalytic network reveals the importance of auxiliary enzymes in lignin biocatalysts
Lignin degradation by biocatalysts is a key strategy to develop a plant-based sustainable carbon economy and thus alleviate global climate change. This process involves synergy between ligninases and...
An analytical model of label-free nanoscale chemical imaging reveals avenues toward improved spatial resolution and sensitivity
Atomic force microscopy–infrared spectroscopy (AFM-IR) is a photothermal scanning probe technique that combines nanoscale spatial resolution with the chemical analysis capability of mid-infrared spect...
Violence against women and girls research: Leveraging gains across disciplines
Violence against women and girls (VAWG) is a leading cause of mortality and morbidity worldwide, linked to numerous health, economic, and human rights outcomes. Target 5.2 of the Sustainable Developme...
Molecular glue for phycobilisome attachment to photosystem II in <i>Synechococcus</i> sp. PCC 7002
Phycobilisomes (PBS) are the major photosynthetic light-harvesting complexes in cyanobacteria and red algae. While the structures of PBS have been determined in atomic resolutions, how PBS are attache...