Proceedings of the National Academy of Sciences
Articles in this Issue
Precise gene editing of pathogenic Lamin A mutations corrects cardiac disease
Mutations in the Lamin A ( LMNA ) gene, which encodes the Lamin A and C proteins, cause severe human diseases collectively known as laminopathies. These conditi...
Smartphone use in a large US adult population: Temporal associations between objective measures of usage and mental well-being
Smartphones are essential tools in daily life yet concerns persist about their potential effects on mental health and well-being. Research on these relationships often relies on subjective measures of...
Climate change impacts on tropical cyclone–induced power outage risk: Sociodemographic differences in outage burdens
This research investigates the projected risks of future climate trends on tropical cyclone–induced power outages in the Gulf and Atlantic coast of the United States, focusing on the disproportionate...
Nanomaterial-induced mitochondrial biogenesis enhances intercellular mitochondrial transfer efficiency
Intercellular mitochondrial transfer, the spontaneous exchange of mitochondria between cells, is a recently described phenomenon crucial for cellular repair, regeneration, and disease management. Enha...
Roles of transposable elements and DNA methylation in the formation of CpG islands and CpG-depleted regulatory elements
The origins of CpG islands (CGIs) are not known. They are relatively short GC-rich regions of DNA with a higher-than-expected occurrence of CpG dinucleotides compared to most of the genome. They const...
Glycan recognition by collectin-11 drives SARS-CoV-2 infectivity and membrane injury of respiratory epithelial cells
SARS-CoV-2 respiratory-tract infection affects both vaccinated and unvaccinated persons suggesting factors besides adaptive immunity are operative. We investigated the role of collectin-11 (CL-11), an...
Lipid raft proteomics identify endothelial myosin-9 (MYH9) as a regulator of low-density lipoprotein transcytosis and atherosclerosis
Background: In early atherosclerosis, circulating Low-Density Lipoprotein (LDL) crosses the endothelium by transcytosis. This involves caveolar uptake of LDL by scavenger receptor BI (SR-BI) and activ...
Improving outbreak forecasts through model augmentation
Accurate forecasts of disease outbreaks are critical for effective public health responses, management of healthcare surge capacity, and communication of public risk. There are a growing number of pow...
A Bayesian perspective on single-shot laser characterization
We introduce a Bayesian framework for measuring spatiotemporal couplings in ultraintense lasers that reconceptualizes what constitutes a “single-shot” measurement. Moving beyond traditional distinctio...
XND1-centered network regulates salt tolerance by integrating root xylem plasticity and Na <sup>+</sup> unloading in <i>Arabidopsis</i>
Soil salinization has emerged as a significant challenge for crop production worldwide. Xylem adjustments through plastic development and sodium unloading from root xylem, as mediated by sodium transp...
Transcriptional condensates encode a “golden mean” to optimize enhancer–promoter communication across genomic distances
Enhancers regulate gene expression by physically contacting their target promoters, yet these contacts often span large genomic distances. Phase-separated condensates (droplet-like clusters) of transc...
A cytoplasmic motif in HLA-E that drives clathrin-mediated endocytosis and VCP-associated postendocytic trafficking
Human Leukocyte Antigen E (HLA-E) is a nonclassical MHC class I molecule that exhibits dual immunological functions in regulating natural killer (NK) cells and T cells through unusual trafficking patt...
A yeast mating platform for multiplex screening of fungal GPCR–ligand interactions
Fungi are essential members across ecosystems, yet phytopathogenic fungi pose an increasing risk to crop yields. Despite their ecologic importance, cell–cell communication in fungi is underexplored, p...
High-resolution ptychographic nanoimaging under high pressure with X-ray beam scanning
We present an approach to nanoscale-resolution high-sensitivity imaging of internal material structure under in situ/operando conditions for virtually any sample environment. When bulky or heavy sampl...
Universal exact solutions for multiphysical inhomogeneities and inclusions in Fourier space
Physical inhomogeneities—spanning atomic-scale crystal defects and quantum dots to macroscopic features like bone cavities and geological faults—are fundamental to both engineered and natural systems....
Single-cell metabolome and RNA-seq multiplexing on single plant cells
Plants produce valuable natural products used for a wide variety of industrial applications. Thus, there is enormous interest in elucidating the biosynthetic pathways that are responsible for the prod...
The genetic lottery goes to school: Better schools compensate for the effects of students’ genetic differences
In this paper, we investigate whether better schools can compensate for the effects of children’s genetic differences. To this end, we combine data from the Norwegian Mother, Father, and Child Cohort...
The dominant sink of oceanic calcium carbonate occurs in undersaturated seawater
Calcium carbonate (CaCO 3 ) particles formed by marine organisms dissolve in seawater and on the ocean floor, constituting a key component of the global ocean c...
A steady-state pool of calcium-dependent actin is maintained by Homer and controls epithelial mechanosensation
Epithelial cells are inherently contractile and in homeostasis, tissue integrity is maintained by balancing the uneven contractile forces in neighboring cells at the cell–cell interface. By contrast,...
Exceptional diversity of allorecognition receptors in a nonvertebrate chordate reveals principles of innate allelic discrimination
Highly polymorphic allorecognition systems have been characterized in numerous invertebrate species, and exhibit discriminatory capabilities reminiscent of vertebrate adaptive immunity. As these syste...
Aberrant X chromosome dosage compensation causes hybrid male inviability in <i>Caenorhabditis</i>
Zygotic reproductive isolation frequently initiates with hybrid incompatibility in the heterogametic sex, such as males in XX/XY systems. The genetic basis of hybrid male incompatibility has long rema...
Genetic regulation of the estrogen receptor and inherited predisposition to breast cancer
For many families severely affected with breast cancer, no inherited causal allele has been detected in any tumor suppressor gene. In an effort to understand the genetics underlying breast cancer in t...
Lamin A/C loss promotes R-loop-mediated genomic instability and poor survival in small-cell lung cancer
Lamin A/C ( LMNA ), a key component of the nuclear envelope, is essential for maintaining nuclear integrity and genome organization [W. Xie...
A PHF19-YTHDC1 condensate switches EZH2-mediated gene suppression to activation for prostate cancer progression
EZH2, a core component of PRC2 complex, silences global gene expression by tri-methylating histone H3K27. It remains an elusive question that EZH2 hyperexpression discords with its H3K27me3 activity o...
Amyloid precursor protein and C99 are subunits in human microglial Hv1 channels that enhance current and inflammatory mediator release
In Alzheimer’s disease (AD), hyperactivated microglia produce inflammatory mediators that contribute to neuroinflammation and neuronal damage. Amyloid precursor protein (APP), a transmembrane protein...