Proceedings of the National Academy of Sciences
Articles in this Issue
Profile of Bruce E. Tabashnik
Reply to Kaestner et al.: Activation of PIEZO1 is not significant for the passage of red blood cells through biomimetic splenic slits
Splenic filtration of red blood cells: Physics, chemistry, and biology need to go hand in hand
Beyond despair: Leveraging ecosystem restoration for psychosocial resilience
Ecosystem restoration has historically been viewed as an ecological endeavor, but restoration possesses significant, yet largely untapped, potential as a catalyst for personal and social transformatio...
Reply to Lockhart et al.: Advancing the understanding of sex differences in functional brain organization with innovative AI tools
Not so binary or generalizable: Brain sex differences with artificial neural networks
The interaction of <i>Serratia</i> bacteria and harmonine in harlequin ladybird confers an interspecies competitive edge
The harlequin ladybird, Harmonia axyridis , is a predatory beetle used globally to control pests such as aphids and scale insects. Originating from East Asia, t...
Dynamic treeline and cryosphere response to pronounced mid-Holocene climatic variability in the US Rocky Mountains
Climate-driven changes in high-elevation forest distribution and reductions in snow and ice cover have major implications for ecosystems and global water security. In the Greater Yellowstone Ecosystem...
Concomitant formation of protocells and prebiotic compounds under a plausible early Earth atmosphere
Revealing the origin of life and unambiguously detecting fossil remains of the earliest organisms are closely related aspects of the same scientific research. The synthesis of prebiotic molecular buil...
Boreal forests are heading for an open state
The boreal forest biome is warming four times faster than the global average. Changes so far are moderate, but time lags in responses may transiently maintain forest states which are no longer support...
A conifer metabolite corrects episodic ataxia type 1 by voltage sensor–mediated ligand activation of Kv1.1
Loss-of-function sequence variants in KCNA1 , which encodes the voltage-gated potassium channel Kv1.1, cause Episodic Ataxia Type 1 (EA1) and epilepsy. Due to a...
Correction to Supporting Information for Le et al., Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS–FTD-linked <i>UBQLN2</i> mutations
Correction for Orellana et al., Childhood maltreatment influences adult brain structure through its effects on immune, metabolic, and psychosocial factors
Correction for Mehmood et al., Teacher vaccinations enhance student achievement in Pakistan: The role of role models and theory of mind
Correction for Tran-Kiem and Bedford, Estimating the reproduction number and transmission heterogeneity from the size distribution of clusters of identical pathogen sequences
Correction for Jury et al., Experimental coral reef communities transform yet persist under mitigated future ocean warming and acidification
Correction for Alboreggia et al., Targeted degradation of Pin1 by protein-destabilizing compounds
Modeling DNA methyltransferase function to predict epigenetic correlation patterns in healthy and cancer cells
DNA methylation is a crucial epigenetic modification that orchestrates chromatin remodelers that suppress transcription, and aberrations in DNA methylation result in a variety of conditions such as ca...
Slower swimming promotes chemotactic encounters between bacteria and small phytoplankton
Chemotaxis enables marine bacteria to increase encounters with phytoplankton cells by reducing their search times, provided that bacteria detect noisy chemical gradients around phytoplankton. Gradient...
Strong adsorption of guanidinium cations to the air–water interface
Combining Deep-UV second harmonic generation spectroscopy with molecular simulations, we confirm and quantify the specific adsorption of guanidinium cations to the air–water interface. Using a Langmui...
The ecdysone-induced bZIP transcription factor MafB establishes a positive feedback loop to enhance vitellogenesis and reproduction in the <i>Aedes aegypti</i> mosquito
Female mosquitoes require a vertebrate blood meal to activate reproduction, transmitting numerous devastating human diseases. Vitellogenesis is a central event of female reproduction that involves the...
An RNase III–processed sRNA coordinates sialic acid metabolism of <i>Salmonella enterica</i> during gut colonization
Sialic acids derived from colonic mucin glycans are crucial nutrients for enteric bacterial pathogens like Salmonella . The uptake and utilization of sialic aci...
The false evidence rate: An approach to frequentist error rate control conditioning on the observed <i>P</i> value
A P value is conventionally interpreted either as a) the probability by chance of obtaining more extreme results than those observed or b) a tool for declaring...
Increasing pesticide diversity impairs soil microbial functions
Pesticide application is essential for stabilizing agricultural production. However, the effects of increasing pesticide diversity on soil microbial functions remain unclear, particularly under varyin...
A signaling molecule from intratumor bacteria promotes trastuzumab resistance in breast cancer cells
Emerging evidence indicates that intratumor bacteria exist as an active and specific tumor component in many tumor types beyond digestive and respiratory tumors. However, the biological impact and res...