Proceedings of the National Academy of Sciences
Articles in this Issue
Gene drives, species complexes, and the risks of collateral damage
Global profiling of polyketide synthases in facultative multicellular eukaryotes
Polyketides represent a structurally diverse class of natural products with a wide range of biological functions, including antimicrobial activity, defense responses, developmental regulation, pigment...
Strategic analysis of dissent and self-censorship
Expressions of dissent against authority are an important feature of most societies, and efforts to suppress such expressions are common. Modern digital communications, social media, and Internet surv...
Robert Haselkorn (1934–2025): Pioneer in molecular biology and microbiology
Robert Haselkorn (1934–2025) began a long and impactful career during the early years of nucleic acids research when the foundations of molecular biology were being laid. Focusing first on plant virus...
Correction for Hazime et al., Nanoscale restructuring of the immune synapse with an engager enhances NK cell function
Correction for Younis et al., CFTR dictates monocyte adhesion by facilitating integrin clustering but not activation
The 2020 US Decennial Census is more private than you (might) think
The US Decennial Census serves as the foundation for many high-profile policy decision-making processes, including federal funding allocation and redistricting. In 2020, the Census Bureau adopted diff...
Loss of calcium-dependent protein kinases OsCPK5 and OsCPK13 leads to NLR-dependent resistance in rice
Calcium (Ca 2+ ) signaling plays a crucial role in plant immunity, regulating both pattern-triggered immunity (PTI) through cell-surface receptors and effector-...
Eliminating intercrystalline side effects for stable lithium metal batteries
Lithium metal is widely recognized as the ultimate anode material for next-generation lithium batteries due to its superior specific capacity. However, microscopic crystallographic heterogeneity cause...
Mapping the placental galectin-3 interactome identifies CD9 and ITGB1 as functional glycoprotein counterreceptors during syncytialization
The fetomaternal interface is replete with glycan-binding proteins (GBPs) that can interact with cell surface glycoprotein counterreceptors to regulate placental function. Here, we interrogate the rol...
Molecular drivers of RNA phase separation
RNA molecules play central roles in the assembly and regulation of biomolecular condensates, often in concert with proteins containing low complexity RNA-binding domains. Recently, it has been shown t...
LHFPL5 is required for maximal activation of the mechanotransduction channel in cochlear hair cells
Mechanoelectrical transduction (MET) channels in cochlear hair cells are gated by tip links through a mechanism that is poorly defined. LHFPL5 interacts with the tip-link component PCDH15 and the MET-...
eATP sensing by the purinergic receptor PA2072 for allosteric modulation in intracellular c-di-GMP signaling
Extracellular ATP (eATP) has emerged as a crucial signaling molecule across eukaryotic and prokaryotic domains, modulating diverse cellular functions by activating purinergic receptors to initiate int...
Microfluidic networks using isotachophoresis
The development of microfluidic technologies has enabled chemical and biological analysis systems with increased functionality, complexity, and parallelization. These functionalities often drive the c...
Exploring evolutionary trajectories of drug resistance
Drug resistance poses a major global health challenge, necessitating the development of effective therapeutic strategies. The main challenge is to predict drug-resistant mutations and design drugs tha...
Extracellular nanobody screening using conformationally stable GPCR variants
G protein–coupled receptors (GPCRs) are prominent drug targets that have attracted intensive efforts in drug screening. Binding-based screening methods for GPCR ligands often require conformationally...
The synergy of methylphenidate- and reconsolidation-based extinction normalizes ventromedial prefrontal function in drug addiction
Drug-related memories can hinder abstinence goals in drug addiction. Promoting nondrugmemories via ventromedial prefrontal cortex (vmPFC)- and amygdala-guided extinctionyields mixed success. Postretri...
Recent immigration raids increased student absences
Local immigration raids expanded dramatically across the United States during the first 2 mo of 2025. Anecdotal accounts suggest that these raids increased student absences from schools because parent...
Electromechanically induced membrane restructuring enables learning and memory
Human neural networks of interconnected neurons have evolved to be remarkably efficient and are capable of learning and memory through the brain’s synaptic plasticity, including short-term plasticity...
ENKD1 attenuates antibacterial immunity by facilitating TRIM21-mediated RUBCN degradation to suppress LC3-associated phagocytosis
Microtubule-associated protein 1A/1B-light chain 3 (LC3)-associated phagocytosis (LAP) plays a critical role in host defense against invading pathogens, including...
Modeling protein–small molecule conformational ensembles with PLACER
Modeling the conformational heterogeneity of protein–small molecule interactions is important for understanding natural systems and evaluating designed systems but remains an outstanding challenge. We...
The lower boundary of workplace mistreatment: Do small slights matter?
Recent research in psychology, management, and more recently in economics, highlights the role of individual managers and their behavior in shaping employee performance. While emerging literature on h...
From sequence to scaffold: Computational design of protein nanoparticle vaccines from AlphaFold2-predicted building blocks
Self-assembling protein nanoparticles are being increasingly utilized in the design of next-generation vaccines due to their ability to induce antibody responses of superior magnitude, breadth, and du...
Peptide vaccine formulations with structurally distinct STING agonist drugamers induce discrete, efficacious antitumor responses
Peptide therapeutic cancer vaccines are an attractive treatment modality for their safety and manufacturability but have been hindered in clinical translation by low immunogenicity and insufficient CD...
Energetically expensive dynamo action in Earth’s basal magma ocean
Previous studies focusing on the electrical conductivity and thermal evolution of an early magma ocean at the base of Earth’s mantle have found that basal magma ocean (BMO) convection could have produ...