Proceedings of the National Academy of Sciences
Articles in this Issue
TIGER: A tdTomato in vivo genome-editing reporter mouse for investigating precision-editor delivery approaches
In vivo genome editing has the potential to address many inherited and environmental disorders. However, a major hurdle for the clinical translation of genome editing is safe, efficient delivery to di...
Nucleotide- and metalloid-driven conformational changes in the arsenite efflux ATPase ArsA
Arsenite (As III ) is toxic to all organisms due to its ability to tightly bind exposed thiols within cells. An important As III...
Universal vortex formation time of flapping flight
Biological flyers periodically flap their appendages to generate aerodynamic forces. Extensive studies have made significant progress in explaining the physics behind their propulsion in cruising by d...
Correction for Ma et al., Setdb1 ablation in macrophages attenuates fibrosis in heart allografts
A unified model of transient poration induced by antimicrobial peptides
Membrane active peptides (MAPs) represent a diverse group of agents that disrupt the integrity of lipid membranes. One class of MAPs, antimicrobial peptides (AMPs), destroy bacteria by transiently por...
Activation of WNK1 signaling through Piezo1
With No lysine (K) 1 (WNK1) is essential for ion and volume homeostasis, sensing osmotic stress and activating pathways that regulate ion transport. Its response to osmotic stress shares similarities...
Sociohydrodynamics: Data-driven modeling of social behavior
Living systems display complex behaviors driven by physical forces as well as decision-making. Hydrodynamic theories hold promise for simplified universal descriptions of socially generated collective...
Reconfigurable photothermal doping filament for selective spin manipulation and addressing
The room temperature manipulation of solid-state spins provides an opportunity to develop quantum applications under ambient conditions. Local electromagnetic fields, that usually produced by current...
A genome-scale drug discovery pipeline uncovers therapeutic targets and a unique p97 allosteric binding site in <i>Schistosoma mansoni</i>
Schistosomes are parasitic flatworms that infect more than 200 million people globally. However, there is a shortage of molecular tools that enable the discovery of potential drug targets within schis...
A theoretical framework for scaling ecological niches from individuals to species
The niche is a key concept that unifies ecology and evolutionary biology. However, empirical and theoretical treatments of the niche are mostly performed at the species level, neglecting individuals a...
Patient stratification reveals the molecular basis of disease co-occurrences
Epidemiological evidence shows that some diseases tend to co-occur; more exactly, certain groups of patients with a given disease are at a higher risk of developing a specific secondary condition. Her...
ARRDC4-mediated glycolysis enhances innate immunity to influenza A virus through fructose-1,6-bisphosphate
Glucose metabolism impacts the innate immune response against viral infection. However, the key enzymes or the natural products and mechanisms involved are not well elucidated. Here, we found that arr...
Correction for Soni et al., BIK polymorphism and proteasome regulation unveil host risk factor for severe influenza
Ingroup solidarity drives social media engagement after political crises
Social media are often said to exacerbate polarization by platforming hostility between groups. However, positive social emotions like ingroup solidarity may also drive social media engagement, partic...
Correction for An et al., Impact of women’s political empowerment through gender quotas on improved drinking water access in Africa
Amyloid β–dependent neuronal silencing through synaptic decoupling
Amyloid β (Aβ)-dependent circuit dysfunction in Alzheimer’s disease (AD) is determined by a puzzling mix of hyperactive and inactive (“silent”) brain neurons. Recent studies identified excessive gluta...
Organoid-based neutralization assays reveal a distinctive profile of SARS-CoV-2 antibodies and recapitulate the real-world efficacy
The efficacy of VIR-7831, a class 3 anti-SARS-CoV-2 monoclonal antibody (mAb), was demonstrated repeatedly in clinical trials; yet, reduced neutralization against Omicron variants in cell-line-based n...
Correction for Kalakonda et al., Monoallelic loss of tumor suppressor GRIM-19 promotes tumorigenesis in mice
Magnetic decoupling as a proofreading strategy for high-yield, time-efficient microscale self-assembly
Life thrives due to its remarkable ability to create complex structures through the self-assembly of proteins, nucleic acids, and other biomolecules. Achieving such complex assemblies with the same le...
Correction for Sun et al., DNA2 protein destruction dictates DNA hyperexcision, cGAS–STING activation, and innate immune response in CDK12-deregulated cancers
CHP1 promotes lipid droplet growth and regulates the localization of key enzymes for triacylglycerol synthesis
The glycerol-3-phosphate (G-3-P) pathway is central to the synthesis of triacylglycerols (TAGs) and glycerophospholipids, essential for membrane biogenesis and lipid storage. The first and rate-limiti...
Echoes in AI: Quantifying lack of plot diversity in LLM outputs
With rapid advances in large language models (LLMs), there has been an increasing application of LLMs in creative content ideation and generation. A critical question emerges: can current LLMs provide...
Parallel trade-offs in human cognition and neural networks: The dynamic interplay between in-context and in-weight learning
Human learning embodies a striking duality: Sometimes, we can rapidly infer and compose logical rules, benefiting from structured curricula (e.g., in formal education), while other times, we rely on a...
Correction for Jankovic et al., Wireless arm-worn bioimpedance sensor for continuous assessment of whole-body hydration
Using large language models to categorize strategic situations and decipher motivations behind human behaviors
By varying prompts to a large language model, we can elicit the full range of human behaviors in a variety of different scenarios in classic economic games. By analyzing which prompts elicit which beh...