Proceedings of the National Academy of Sciences
Articles in this Issue
Greener skies? The quest for sustainable flying
Urban groundwater supplies facing dual pressures of depletion and contamination in China
Groundwater is essential to urban water supplies throughout the world, but we do not understand how quantity and quality issues may jeopardize the ability of cities to meet their water needs. Here, we...
Subfunctionalization and epigenetic regulation of a biosynthetic gene cluster in <i>Solanaceae</i>
Biosynthetic gene clusters (BGCs) are sets of often heterologous genes that are genetically and functionally linked. Among eukaryotes, BGCs are most common in plants and fungi and ensure the coexpress...
Listen for a change? A longitudinal field experiment on listening’s potential to enhance persuasion
Scholars and practitioners widely posit that listening to other people enhances efforts to persuade them. Listening may enhance persuasion by promoting cognitive processing, reducing defensiveness, an...
Resolved—Editorial Expression of Concern for Duckworth et al., Role of test motivation in intelligence testing
Structural requirements of KAI2 ligands for activation of signal transduction
Karrikin Insensitive 2 (KAI2), identified as the receptor protein for karrikins (KARs), which are smoke-derived seed germination stimulants, belongs to the same α/β-hydrolase family as D14, the recept...
Evolutionary rewiring of the dynamic network underpinning allosteric epistasis in NS1 of the influenza A virus
Viral proteins frequently mutate to evade host innate immune responses, yet the impact of these mutations on the molecular energy landscape remains unclear. Epistasis, the intramolecular communication...
Planar device–enabled speckle illumination for dark-field label-free imaging beyond the diffraction limit
Dark-field microscopy is a technique used in optical microscopy to increase the contrast in unstained samples, making it possible to observe details that would otherwise be difficult to see under brig...
Explicitly unbiased large language models still form biased associations
Large language models (LLMs) can pass explicit social bias tests but still harbor implicit biases, similar to humans who endorse egalitarian beliefs yet exhibit subtle biases. Measuring such implicit...
Manipulating hydrogenation pathways enables economically viable electrocatalytic aldehyde-to-alcohol valorization
Electrocatalytic reduction (ECR) of furfural represents a sustainable route for biomass valorization. Unfortunately, traditional Cu-catalyzed ECR suffers from diversified product distribution and indu...
A structural atlas of death domain fold proteins reveals their versatile roles in biology and function
Death domain fold (DDF) superfamily proteins are critically important players in pathways of cell death and inflammation. DDFs are often essential scaffolding domains in receptors, adaptors, or effect...
<i>Enterobacter hormaechei</i> replaces virulence with carbapenem resistance via porin loss
Pathogenic Enterobacter species are of increasing clinical concern due to the multidrug-resistant nature of these bacteria, including resistance to carbapenem a...
Temporal autocorrelation is predictive of age—An extensive MEG time-series analysis
Understanding the evolving dynamics of the brain throughout life is pivotal for anticipating and evaluating individual health. While previous research has described age effects on spectral properties...
A novel quinone biosynthetic pathway illuminates the evolution of aerobic metabolism
The dominant organisms in modern oxic ecosystems rely on respiratory quinones with high redox potential (HPQs) for electron transport in aerobic respiration and photosynthesis. The diversification of...
Poly(ADP-ribose) binding sites on collagen I fibrils for nucleating intrafibrillar bone mineral
Bone calcification is essential for vertebrate life. The mechanism by which mineral ions are transported into collagen fibrils to induce intrafibrillar mineral formation requires a calcium binding bio...
Learning-based inference of longitudinal image changes: Applications in embryo development, wound healing, and aging brain
Longitudinal imaging data are routinely acquired for health studies and patient monitoring. A central goal in longitudinal studies is tracking relevant change over time. Traditional methods remove nui...
The endocannabinoid 2-arachidonoylglycerol is released and transported on demand via extracellular microvesicles
While it is known that endocannabinoids (eCB) modulate multiple neuronal functions, the molecular mechanism governing their release and transport remains elusive. Here, we propose an “...
Resilience of the electric grid through trustable IoT-coordinated assets
The electricity grid has evolved from a physical system to a cyberphysical system with digital devices that perform measurement, control, communication, computation, and actuation. The increased penet...
Mussel-inspired cross-linking mechanisms enhance gelation and adhesion of multifunctional mucin-derived hydrogels
Mucus supports human health by hydrating, lubricating, and preventing infection of wet epithelial surfaces. The beneficial material properties and bioactivity of mucus stem from glycoproteins called m...
Druggable genome screens identify SPP as an antiviral host target for multiple flaviviruses
Mosquito-borne flaviviruses, such as dengue virus (DENV), Zika virus (ZIKV), West Nile virus, and yellow fever virus, pose significant public health threats globally. Extensive efforts have led to the...
Biophysical modeling of membrane curvature generation and curvature sensing by the glycocalyx
Generation of membrane curvature is fundamental to cellular function. Recent studies have established that the glycocalyx, a sugar-rich polymer layer at the cell surface, can generate membrane curvatu...
Cryo-EM of native membranes reveals an intimate connection between the Krebs cycle and aerobic respiration in mycobacteria
To investigate the structure of the mycobacterial oxidative phosphorylation machinery, we prepared inverted membrane vesicles from Mycobacterium smegmatis , enr...
Profile of Mark Kirkpatrick
Nongenetic adaptation by collective migration
Cell populations must adjust their phenotypic composition to adapt to changing environments. One adaptation strategy is to maintain distinct phenotypic subsets within the population and to modulate th...
Integrative analysis of KCNQ1 variants reveals molecular mechanisms of type 1 long QT syndrome pathogenesis
Loss-of-function (LOF) pathogenic variants in KCNQ1 encoding a cardiac potassium channel predispose to sudden cardiac death in type 1 congenital long QT syndrom...