Proceedings of the National Academy of Sciences
Articles in this Issue
Correction for Zhang et al., Facet-switching of rate-determining step on copper in CO <sub>2</sub> -to-ethylene electroreduction
Correction for D’Angelo et al., A paradoxical misperception of relative motion
Correction for Matsuzaki et al., Transcriptional drift in aging cells: A global decontroller
Action potential–independent spontaneous microdomain Ca <sup>2+</sup> transients–mediated continuous neurotransmission regulates hyperalgesia
Neurotransmitters and neuromodulators can be released via either action potential (AP)–evoked transient or AP-independent continuous neurotransmission. The elevated AP-evoked neurotransmission in the...
An evolutionarily conserved cation channel tunes the sensitivity of gustatory neurons to ephaptic inhibition in <i>Drosophila</i>
In ephaptic coupling, physically adjacent neurons influence one another’s activity via the electric fields they generate. To date, the molecular mechanisms that mediate and modulate ephaptic coupling’...
Precision data-driven modeling of cortical dynamics reveals person-specific mechanisms underpinning brain electrophysiology
Task-free brain activity affords unique insight into the functional structure of brain network dynamics and has been used to identify neural markers of individual differences. In this work, we present...
Conformity to continuous and discrete ordered traits
Models of conformity and anticonformity have typically focused on cultural traits with unordered variants, such as baby names, strategies (cooperate/defect), or the presence/absence of an innovation....
A solution to the pervasive problem of response bias in self-reports
Self-reports are used ubiquitously to probe people’s thoughts, feelings, and behaviors and inform medical decisions, enterprise operations, and government policy and legislation. Despite their pervasi...
Nitrous oxide production via enzymatic nitroxyl from the nitrifying archaeon <i>Nitrosopumilus maritimus</i>
Ammonia oxidizing archaea (AOA) are among the most abundant microorganisms on earth and are known to be a major source of nitrous oxide (N 2 O) emissions, altho...
Stimulating the regenerative capacity of the human retina with proneural transcription factors in 3D cultures
Retinal diseases often lead to degeneration of specific retinal cell types with currently limited therapeutic options to replace the lost neurons. Previous studies have reported that overexpression of...
The population dynamics of clustered consumer–resource spatial patterns: Insights from the demographics of a Turing mechanism
In ecology, Alan Turing’s proposed activation–inhibition mechanism has been abstracted as corresponding to several ecological interaction types to explain pattern formation in ecosystems. Consumer–res...
Plant BCL-DOMAIN HOMOLOG proteins play a conserved role in SWI/SNF complex stability
The SWItch/Sucrose Non-Fermenting (SWI/SNF) complexes are evolutionarily conserved, ATP-dependent chromatin remodelers crucial for multiple nuclear functions in eukaryotes. Recently, plant BCL-DOMAIN...
Crucial role of the cGAS N terminus in mediating flowable and functional cGAS–DNA condensate formation via DNA interactions
The DNA-sensing protein cGAS plays a pivotal role in the innate immune response and pathogenesis of various diseases. DNA triggers liquid–liquid phase separation (LLPS) and enhances the enzymatic acti...
Discrepancies between subjective and objective sleep assessments revealed by in-home electroencephalography during real-world sleep
Sleep insufficiency and sleep disorders pose serious health challenges. This study aimed to determine the potential discrepancy between subjective and objective sleep assessments, including the latter...
Fungal evasion of <i>Drosophila</i> immunity involves blocking the cathepsin-mediated cleavage maturation of the danger-sensing protease
Entomopathogenic fungi play a critical role in regulating insect populations, and representative species from the Metarhizium and Beauveria...
How to address solar geoengineering’s transparency problem
Random noise promotes slow heterogeneous synaptic dynamics important for robust working memory computation
Recurrent neural networks (RNNs) based on model neurons that communicate via continuous signals have been widely used to study how cortical neural circuits perform cognitive tasks. Training such netwo...
Assembly-enhanced recognition: A biomimetic pathway to achieve ultrahigh affinities
On the one hand, nature utilizes hierarchical assemblies to create complex biological binding pockets, enabling ultrastrong recognition toward substrates in aqueous solutions. On the other hand, chemi...
Joseph G. Gall (1928–2024): A naturalist and scholar for the genomic era
Spatially programmed alignment and actuation in printed liquid crystal elastomers
Liquid crystal elastomers (LCEs) exhibit reversible shape morphing behavior when cycled above their nematic-to-isotropic transition temperature. During extrusion-based 3D printing, LCE inks are subjec...
Dual modes of DNA N <sup>6</sup> -methyladenine maintenance by distinct methyltransferase complexes
Stable inheritance of DNA N 6 -methyladenine (6mA) is crucial for its biological functions in eukaryotes. Here, we identify two distinct methyltransferase (MTas...
Tuning the electronic structure and SMSI by integrating trimetallic sites with defective ceria for the CO <sub>2</sub> reduction reaction
Heterogeneous catalysts have emerged as a potential key for closing the carbon cycle by converting carbon dioxide (CO 2 ) into value-added chemicals. In this wo...
CFTR dictates monocyte adhesion by facilitating integrin clustering but not activation
Monocytes are critical in controlling tissue infections and inflammation. Monocyte dysfunction contributes to the inflammatory pathogenesis of cystic fibrosis (CF) caused by CF transmembrane conductan...
A distributed subcortical circuit linked to instrumental information-seeking about threat
Daily life for humans and other animals requires switching between periods of threat- and reward-oriented behavior. We investigated neural activity associated with spontaneous switching, in a naturali...
Soil microbiome bacteria protect plants against filamentous fungal infections via intercellular contacts
Bacterial–fungal interaction (BFI) has significant implications for the health of host plants. While the diffusible antibiotic metabolite-mediated competition in BFI has been extensively characterized...