Proceedings of the National Academy of Sciences
Articles in this Issue
Characterizing a highly excited and sustained brain response activity during gaming: P300-CE
Inspired by the high engagement and sustained behavioral excitement observed in video game players, we hypothesized that distinct brain activity patterns occur during gaming compared to a generic nong...
Spatiotemporal decoupling of floristic endemism in response to Qinghai–Tibet Plateau uplift
Correction to Supporting Information for Seigneur et al., Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs
Retraction for Kundu et al., Selective neutralization of IL-12 p40 monomer induces death in prostate cancer cells via IL-12–IFN-γ
Tautomerism induces bending and twisting of biogenic crystals
Understanding and exploiting material flexibility through phenomena such as the bending and twisting of molecular crystals has been a subject of increased interest owing to the number of applications...
Mutualism between degraders and nondegraders stabilizes the function of a natural biopolymer-degrading community
Natural biopolymer-degrading microbial communities drive carbon biogeochemical cycling. Within these communities, polymer degraders facilitate the growth of nondegraders by breaking down polymers thro...
RACK1A positively regulates opening of the apical hook in <i>Arabidopsis thaliana</i> via suppression of its auxin response gradient
Apical hook development is an ideal model for studying differential growth in plants and is controlled by complex phytohormonal crosstalk, with auxin being the major player. Here, we identified a bioa...
Correction to Supporting Information for Gozashti et al., Horizontal transmission of functionally diverse transposons is a major source of new introns
A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human condition
Angelman syndrome is a neurodevelopmental disorder characterized by severe motor and cognitive deficits. It is caused by the loss of the maternally inherited allele of the imprinted ubiquitin-protein...
Unprecedentedly high global forest disturbance due to fire in 2023 and 2024
Global forests provide key ecosystem services, from climate regulation to biodiversity habitat, but are under increasing pressure from the combined impacts of climate and land use change. Here, we sho...
Thioether editing generally increases the photostability of rhodamine dyes on self-labeling tags
Self-labeling protein tags are widely used in advanced bioimaging where dyes with high-photon budgets outperform their fluorescent protein counterparts. Further increasing the emitted photon numbers o...
Retraction for Goswami et al., A bifunctional tRNA import receptor from <i>Leishmania</i> mitochondria
Phage-based delivery of CRISPR-associated transposases for targeted bacterial editing
Phage λ, a well-characterized temperate phage, has been recently leveraged for bacterial genome editing by selectively delivering base editors into targeted bacterial species. We extend this concept b...
<i>Cdc42</i> defect reveals insights into microvilli organization and function in T cell immunity
Microvilli on T cells differ from those on epithelial cells, exhibiting filopodia-like characteristics that facilitate the clustering of molecules essential for sensing and cell migration. Recently, t...
Trigger factor accelerates nascent chain compaction and folding
Conformational control of nascent chains is poorly understood. Chaperones are known to stabilize, unfold, and disaggregate polypeptides away from the ribosome. In comparison, much less is known about...
Effects of the gut microbiota on placental angiogenesis and intrauterine growth in gnotobiotic mice
Environmental causes of intrauterine growth restriction (IUGR) remain poorly characterized. Here, we compare germ-free (GF) and conventionally raised (CONV-R) mice to assess the effects of the gut mic...
How publics in small-island states view climate change and international responses to it
Climate change caused by carbon pollution from the world’s largest economies poses an existential threat to small-island states and territories this century. These places bear virtually no responsibil...
Bivalent interaction through an intrinsically disordered linker promotes transcription activation complex assembly in Notch signaling
The Notch signaling pathway regulates cellular differentiation by activating transcription through an unusual heterotrimeric complex comprising the Notch receptor’s intracellular domain (NICD), the DN...
Differential representations of spatial location by aperiodic and alpha oscillatory activity in working memory
Decades of research have shown working memory (WM) relies on sustained prefrontal cortical activity and visual extrastriate activity, particularly in the alpha (8 to 12 Hz) frequency range. This alpha...
Seed dispersal disruption limits tropical forest regrowth
Identifying linkages between biodiversity loss and climate change is required for understanding the scope of these interconnected challenges and developing approaches to address them. One crucial yet...
Correction for Lin et al., BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1–Chk1 pathway, implicating checkpoint dysfunction in microcephaly
Epigenetic instability and hypofunctionality of fetal Tregs allow a permissive regulatory environment for T effector memory maturation
The human gestational environment is commonly perceived to be predominantly suppressive and incompatible for T effector maturation. However, evidence of a competent effector fetal environment is mount...
Cell type–specific purifying selection of synonymous mitochondrial DNA variation
While somatic variants are well-characterized drivers of tumor evolution, their influence on cellular fitness in nonmalignant contexts remains understudied. We identified a mosaic synonymous variant (...
Exploring the social life of urban spaces through AI
We analyze changes in pedestrian behavior over a 30-y period in four urban public spaces located in New York, Boston, and Philadelphia. Building on William Whyte’s observational work, which involved m...
Soil nitrogen drives inverse acclimation of xylem growth cessation to rising temperature in Northern Hemisphere conifers
Controlled experiments suggest that the seasonal build-up of nitrogen (N) limitation constrains the responses of forest autumn phenology to elevated temperatures. Therefore, rising soil N is expected...