Proceedings of the National Academy of Sciences
Articles in this Issue
The modern pattern of insect herbivory predates the advent of angiosperms by 60 My
Modern ecosystems display complex associations of plants–insects that underwent a long evolutionary process since the appearance of mid-Paleozoic vascular plants. Although several major hypotheses exp...
Correction to Supporting Information for Melo et al., Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing
Correction for Schmidt et al., Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2
Correction for Wu et al., Hapalindole Q suppresses autophagosome−lysosome fusion by promoting YAP1 degradation via chaperon-mediated autophagy
Correction for Atlas et al., Turbulence in the tropical stratosphere, equatorial Kelvin waves, and the quasi-biennial oscillation
Molecular patterns of matrix protein 1 (M1): A strong predictor of adaptive evolution in H9N2 avian influenza viruses
The H9N2 subtype of avian influenza virus (AIV) emerges as a significant member of the influenza A virus family. However, the varying degrees of epidemiological dominance among different lineages or c...
The synergistic effect of c-Myb hyperactivation and Pu.1 deficiency induces Pelger–Huët anomaly and promotes sAML
Approximately 30% of patients with myelodysplastic syndrome (MDS) progress to secondary acute myeloid leukemia (sAML) via accumulating gene mutations. Genomic analyses reveal a complex interplay among...
A numerically exact description of ultrafast vibrational decoherence in vibration-coupled electron transfer
Broadband pump–probe spectroscopy has been widely used to measure vibrational decoherence associated with the reaction coordinate in photoinduced ultrafast vibration-coupled electron transfer (VCET) r...
Long-term B cell memory emerges at uniform relative rates in the human immune response
B cells generate pathogen-specific antibodies and play an essential role in providing adaptive protection against infection. Antibody genes are modified in evolutionary processes acting on the B cell...
Defects induce phase transition from dynamic to static rippling in graphene
Two-dimensional (2D) materials display nanoscale dynamic ripples that significantly impact their properties. Defects within the crystal lattice are the elementary building blocks to tailor the materia...
A degenerate telomerase RNA directs telomeric DNA synthesis in lepidopteran insects
Telomerase elongates telomeres to maintain chromosome stability in most eukaryotes. Despite extensive studies across eukaryotic kingdoms, the telomerase holoenzyme in arthropods remains poorly underst...
Disruption of G3BP1 granules promotes mammalian CNS and PNS axon regeneration
Depletion or inhibition of core stress granule proteins, G3BP1 in mammals and TIAR-2 in Caenorhabditis elegans , increases the growth of spontaneously regenerat...
Tandem metabolic reaction–based sensors unlock in vivo metabolomics
Mimicking metabolic pathways on electrodes enables in vivo metabolite monitoring for decoding metabolism. Conventional in vivo sensors cannot accommodate underlying complex reactions involving multipl...
Understanding Nash epidemics
Faced with a dangerous epidemic humans will spontaneously social distance to reduce their risk of infection at a socioeconomic cost. Compartmentalized epidemic models have been extended to include thi...
Erythroid progenitor cell–mediated spleen–tumor interaction deteriorates cancer immunity
Understanding both local and systemic immunity is essential to optimizing the effectiveness of immunotherapy. However, the dynamic alterations in systemic immunity during tumor development are yet to...
S-Nitrosylation of CRTC1 in Alzheimer’s disease impairs CREB-dependent gene expression induced by neuronal activity
cAMP response element-binding protein (CREB)-regulated transcription coactivator 1 (CRTC1) plays an important role in synaptic plasticity, learning, and long-term memory formation through the regulati...
Multiscale toughening mechanisms in biomimetic tendon-like hydrogels
Mimicking hierarchical structures found in nature, such as nacre and tendon, has led to remarkable successes in the creation of biomimetic materials with exceptional properties. The depth of knowledge...
Photon-drag photovoltaic effects and quantum geometric nature
The bulk photovoltaic effect (BPVE) generates a direct current photocurrent under uniform irradiation and is a nonlinear optical effect traditionally studied in noncentrosymmetric materials. The two m...
Physics-informed deep learning for stochastic particle dynamics estimation
Single-particle tracking has enabled quantitative studies of complex systems, providing nanometer localization precision and millisecond temporal resolution in heterogeneous environments. However, at...
High-resolution structures of Myosin-IC reveal a unique actin-binding orientation, ADP release pathway, and power stroke trajectory
Myosin-IC (myo1c) is a class-I myosin that supports transport and remodeling of the plasma membrane and membrane-bound vesicles. Like other members of the myosin family, its biochemical kinetics are a...
Functional mapping of the molluscan brain guided by synchrotron X-ray tomography
Molluscan brains are composed of morphologically consistent and functionally interrogable neurons, offering rich opportunities for understanding how neural circuits drive behavior. Nonetheless, detail...
Multiomics analysis unveils the cellular ecosystem with clinical relevance in aldosterone-producing adenomas with <i>KCNJ5</i> mutations
Aldosterone-producing adenomas (APA), a major endocrine tumor and leading subtype of primary aldosteronism, cause secondary hypertension with high cardiometabolic risks. Despite potentially producing...
Cryo-EM heterogeneity analysis using regularized covariance estimation and kernel regression
Proteins and the complexes they form are central to nearly all cellular processes. Their flexibility, expressed through a continuum of states, provides a window into their biological functions. Cryoge...
Directed evolution of a sequence-specific covalent protein tag for RNA labeling
Efficient methods for conjugating proteins to RNA are needed for RNA delivery, imaging, editing, interactome mapping, and barcoding applications. Noncovalent coupling strategies using viral RNA bindin...