Proceedings of the National Academy of Sciences
Articles in this Issue
<i>Drosophila</i> Ahcy is a redox sensor that modulates gene expression to protect against light stress–induced retinal degeneration
One-carbon metabolism influences gene expression by providing methyl units for DNA, RNA, and histone methylation. Robust methylation requires rapid hydrolysis of the methylation by-product...
Active billiards: Engineering boundaries for the spatial control of confined active particles
Unlike gas molecules at equilibrium, the spatial organization of self-propelled particles can be very sensitive to what happens at the boundaries of their container. Understanding the link between bou...
Correction for Tobias et al., Biodiversity conservation requires integration of species-centric and process-based strategies
Historical and experimental evidence that inherent properties are overweighted in early scientific explanation
Scientific explanation is one of the most sophisticated forms of human reasoning. Nevertheless, here we hypothesize that scientific explanation is susceptible to some of the same biases that influence...
Rootworm resistance to Bt associated with increased injury to corn pyramids combining Bt proteins and RNA interference
Crops genetically engineered to produce insecticidal proteins from the bacterium Bacillus thuringiensis (Bt) have revolutionized pest management, but their bene...
Stress-induced preference for antioxidants by <i>Drosophila</i>
In an ever-changing environment, animals make optimal decisions to ensure their well-being. Faced with limited food sources, they often seek foods that provide the nutrients they require to maintain h...
Divergent sustainability profiles of molnupiravir synthesis routes are governed by solvent use and process design
This study presents a comparative cradle-to-gate environmental and economic evaluation of nine synthetic routes for Molnupiravir (EIDD-2801), a broad-spectrum antiviral drug. Integrating Life Cycle As...
A model for boundary-driven tissue morphogenesis
Tissue deformations during morphogenesis can be active, driven by internal processes, or passive, resulting from stresses applied at their boundaries. Here, we introduce the Drosop...
Enhanced visualization of influenza A virus entry into living cells using virus-view atomic force microscopy
Influenza A virus (IAV) entry into host cells begins with interactions between the viral envelope proteins hemagglutinin (HA)/neuraminidase (NA) and sialic acid moieties on the cell plasma membrane. T...
Protein-mediated stabilization and nicking of the nontemplate DNA strand dramatically affect R-loop formation in vitro
R-loops are an important class of non-B DNA structures that form co-transcriptionally. Using in vitro transcription and unbiased quantitative sequencing readouts, we show that the addition of single-s...
Virion proteomics of genetically intact HCMV reveals a regulator of envelope glycoprotein composition that protects against humoral immunity
Human cytomegalovirus (HCMV) is a clinically important herpesvirus that has coevolved for millions of years with its human host, and establishes lifelong persistent infection. A substantial proportion...
Inverse design of parameter-controlled disclination paths
Topological defects, such as disclination lines in nematic liquid crystals, are fundamental to many physical systems and applications. In this work, we study the behavior of nematic disclinations in t...
Large-scale surveys of woodrats ( <i>Neotoma</i> spp.) reveal constraints on diet breadth in herbivorous mammals
Characterizing niche space is critical for predicting species interactions and responses to environmental change. To enhance our understanding of dietary niche breadth, we used DNA metabarcoding to ex...
C4d, a high-affinity LilrB2 ligand, is elevated in Alzheimer’s disease and mediates synapse pruning
Synapse pruning sculpts neural circuits throughout life. The human Leukocyte immunoglobulin-like receptor type B2 (LilrB2)/murine Paired immunoglobulin receptor B (PirB) receptors expressed in neurons...
Dimerization propensity of the β <sub>1</sub> -adrenergic receptor in lipid nanodiscs probed by DEER and single-molecule spectroscopies
G protein–coupled receptors (GPCRs) comprise a large class of membrane proteins that mediate cellular responses to a wide range of external signals and as such constitute major drug targets. While oli...
Nanoscale restructuring of the immune synapse with an engager enhances NK cell function
Engagers are antibody-based therapies which bind immune cell receptors and a target cell ligand. Next-gen engagers typically bind two activating receptors, but the effect of this on immune synapse for...
Nuclear receptor coregulator NRIP1 R448G modulates T cell gut homing to control intestinal inflammation
Nuclear receptors (NRs) are crucial to integrate metabolite sensing and immune responses in the gut. NR-interacting protein 1 (NRIP1) is an important coregulator of various NRs that has been implicate...
Community notes reduce engagement with and diffusion of false information online
Social networks scaffold the diffusion of information on social media. Much attention has been given to the spread of true vs. false content on online social platforms, including the structural differ...
Lymphatic dysfunction is linked to disease pathogenesis in Duchenne muscular dystrophy animal models
Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disorder characterized by progressive muscle weakness and inflammation caused by mutations in the DMD gene. Chronic inflammation in DMD exa...
ComFB, a widespread family of c-di-NMP receptor proteins
Cyclic dimeric-GMP (c-di-GMP) is a ubiquitous bacterial second messenger that regulates a variety of cellular processes, including motility, biofilm formation, secretion, cell cycle progression, and d...
Reprogrammable sequencing for physically intelligent underactuated robots
Programming physical intelligence into mechanisms holds great promise for machines that can accomplish tasks such as navigation of unstructured environments while utilizing a minimal amount of computa...
Cryo-EM structure of the prohibitin complex in open conformation
Prohibitin 1 (PHB1) and Prohibitin 2 (PHB2), two conserved prohibitin members, are primarily localized to the mitochondrial inner membrane (MIM) to form a nanoscale macromolecular prohibitin complex....
USP14-mediated metabolic competition impairs CD8+ T cell immunosurveillance in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) frequently develops resistance to CD8+ T cell–based immunotherapy, yet the mechanisms driving this immune evasion remain poorly understood. To identify tumor-intrinsic r...
The balance between microbial arsenic methylation and demethylation in paddy soils underpins global arsenic risk and straighthead disease in rice
Arsenic contamination in rice poses a global challenge to food safety and agricultural productivity, as toxic methylated arsenic species—dimethylarsinic acid (DMA) and its highly toxic derivative, met...