Proceedings of the National Academy of Sciences
Articles in this Issue
Biomarker <i>δ</i> <sup>13</sup> C values record consistent savanna vegetation and variable alkalinity of Lake Olduvai during Pleistocene wet/dry cycles
Climate records for the early Pleistocene in eastern Africa aid reconstruction of the ecology and landscapes occupied by hominins. Environmental changes associated with alternating wet/dry cycles duri...
Food absence is a cue for metamorphosis in the solitary bee <i>Megachile rotundata</i> through a conserved physiological mechanism
The timing of metamorphosis in insects determines adult body size and influences aspects of fitness including flight performance and fecundity. The regulation of metamorphosis has been well studied in...
Evaluating inbreeding and assessing the risk of outbreeding depression in genetic rescue using whole-genome sequence data
Restoring genetic diversity through assisted migration is increasingly recognized as a crucial strategy to counteract inbreeding depression and boost genetic variation in small and fragmented populati...
Enhanced insulin signaling via circulating ATG7: A potential therapeutic strategy for diabetes
Diabetes and insulin resistance (IR) remain major global health challenges, underscoring the need for novel therapeutic strategies. Here, we identify an autophagy-independent role of circulating autop...
Resistance, heteroresistance, and fitness costs drive colistin treatment failure during <i>Acinetobacter baumannii</i> pneumonia
Acinetobacter baumannii is an Enterococcus , Staphylococcus , Klebsiella...
Universality for Taylor coefficients of rational functions under perturbations
We introduce computational methods for analytic combinatorics in several variables. Our findings pertain to rational generating functions whose dominant singularity satisfies either of two conditions,...
Repeated major inland retreat of Thwaites and Pine Island glaciers (West Antarctica) during the Pliocene
The stability of the West Antarctic Ice Sheet (WAIS), crucial for predicting future sea-level rise, is threatened by ocean-forced melting in the Pacific sector of the Southern Ocean. While some geolog...
Maintaining microbiota across diverse symbiotic organs in <i>Euprymna scolopes</i> : Insights into shared immune responses
Many animals have multiple organs or tissues that are colonized by diverse microbiota. The female Hawaiian bobtail squid, Euprymna scolopes , has two organs wit...
Acclimation to high and low diurnal light is flexible in <i>Chlamydomonas reinhardtii</i>
Chlamydomonas acclimates to repeated low (LL) or high light (HL) days by changing the abundance of photosynthetic complexes and the ultrastructure of its thylakoid membranes. These phenotypes persist...
Host–microbiome mutualism drives urea carbon salvage and acetogenesis during hibernation
Hibernation is a seasonal survival strategy employed by certain mammals that, through torpor use, reduces overall energy expenditure and permits long-term fasting. Although fasting solves the challeng...
Social attraction to a predatory black hole: A natural ecological trap for lobsters
Ecological traps occur when animals erroneously choose habitats that lower their fitness, drawn by cues that are adaptive in most instances, but not all. Most ecological traps result from anthropogeni...
Computer-assisted learning in the real world: How Khan Academy influences student math learning
Computer-assisted learning (CAL) offers an affordable way to implement a mastery learning approach in the classroom. However, while experimental research suggests CAL can enhance student outcomes, suc...
Exploring the interplay between protein conformational changes and phosphorylation in a pancreatic cancer cell and stellate cell coculture system
A global exploration of the complex interplay between protein conformational changes and phosphorylation events in cell–cell interactions is crucial for understanding the dynamic nature of protein mod...
Antagonistic regulation of nitrogen and drought signaling mediated by NIN-like protein 7 transcription factor in <i>Arabidopsis thaliana</i>
Plants face the constant challenge of reconciling antagonistic environmental signals, such as nutrient-driven growth and water deficit–induced stress responses. However, the molecular mechanisms that...
Correction for Li et al., Tubular ACSM3 deficiency impairs medium-chain fatty acid metabolism and aggravates kidney fibrosis
Interpretable early warnings using machine learning in an online game-experiment
Stemming from physics and later applied to other fields such as ecology, the theory of critical transitions suggests that some regime shifts are preceded by statistical early warning signals. Reddit’s...
Polyserine domains are toxic and exacerbate tau pathology in mice
Polyserine domains mediate the association of some nuclear RNA-binding proteins with cytoplasmic tau aggregates occurring in tauopathy models and patient samples. In cell lines, polyserine domains med...
Dietary folic acid prevents peripheral neuropathy in mouse models of neural tube defects and type 2 diabetes
Folate-mediated one-carbon metabolism is implicated in several pathologies including neural tube defects (NTDs), cancer, and neurodegenerative disorders, whereas diabetes is associated with NTDs and p...
Machine learning reveals hidden dimensions of functional similarity in proteins
Reply to Benito et al.: Problems in the Cretaceous evolution of the avian palatobasal joint
Modeling and inferring metacommunity dynamics with Maximum Caliber
A major challenge for community ecology is using spatiotemporal data to infer parameters of dynamical models without conducting laborious experiments. We present a framework from statistical physics—M...
Fluorinated lipid nanoparticles enable real-time tracking of mRNA delivery and uncover spatiotemporal mechanisms of immune activation
Messenger RNA (mRNA) vaccines rely on lipid nanoparticles (LNPs) for in vivo delivery, yet conventional formulations exhibit inefficient tissue targeting, undesired hepatic accumulation, and limited u...
Antibody responses to a highly conserved peptide in HCV E2 protein correlate with chronicity or spontaneous clearance of HCV infection
Hepatitis C virus (HCV) infection frequently progresses to chronicity rather than spontaneous clearance, resulting in severe liver diseases including cirrhosis and hepatocellular carcinoma. The molecu...
Gradient interfacial water dynamics for stable aqueous metal anodes
The deployment of renewable energy necessitates reliable grid-scale storage technologies. Aqueous metal battery systems are one of the promising candidates due to high safety, low cost, and high theor...
Saccade-related LFP power transients in the primate amygdala and hippocampus linked to the perception of social status
A key aspect of healthy social functioning in both humans and nonhuman primates is the ability to extract status-related information from observing the social signals exchanged between individuals. Kn...