Proceedings of the National Academy of Sciences
Articles in this Issue
Source limitation drives slow compositional recovery in tropical secondary forests
Tropical forests can recover diversity, structure, and function rapidly after disturbance. However, plant compositional recovery remains incomplete even after many decades, and the reasons for this la...
Dietary DNA in municipal wastewater reveals signatures of wealth, immigration, and coastal proximity
Public health nutrition lacks scalable, objective tools for real-time dietary surveillance. We developed FoodSeq-FLOW (Food Landscape Observation in Wastewater), a genomic platform that sequences chlo...
Correction for Newman et al., The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity
A generative model for bipartite gene-sharing networks
Gene-sharing networks provide a powerful framework to study the evolution of viruses and mobile genetic elements. These bipartite networks, which link genes to the genomes that contain them, exhibit c...
Spatiotemporal control of Atg2 association with the ER during autophagosome formation
Autophagy degrades various intracellular components by sequestering them within membrane vesicles called autophagosomes and delivering them to lysosomes or vacuoles. Previous studies have revealed tha...
Cryoelectron tomography reveals an age-related decline in mitoribosomes that contributes to T cell dysfunction in older individuals
Mitochondrial dysfunction drives T cell aging in mice. Yet, due to fundamental differences in T cell aging mechanisms between species, whether human T cells exhibit similar mitochondrial alterations r...
A fungal effector inhibits plant MAPK signaling by acting as a decoy substrate of MKK5
Plant immune responses rely on mitogen-activated protein kinase (MAPK) cascade that integrates pattern-triggered immunity and effector-triggered immunity. How fungal pathogens suppress this central si...
Effective mass of a migrating interface
Interfaces are ubiquitous in materials and play a central role in microstructural evolution and material properties. Although interface migration has been studied for more than a century and remains a...
A posttranslational modification of fimbriae drives pathogenicity in <i> <i>Klebsiella pneumoniae</i> </i>
Antimicrobial resistance is a severe public health burden. Especially concerning are multidrug resistant (MDR) infections, which restrict treatment options and significantly increase mortality risk. A...
Sediment accumulation rate predicts the temporal resolution of marine fossil assemblages
Time averaging (TA), the mixing of noncontemporaneous organisms in fossil assemblages, governs the resolution of paleontological data and determines which biological and environmental processes are re...
AI will reorganize science. Will research remain a human enterprise?
RelB NF-κB tunes Notch2 signaling to promote IL-23-secreting solitary isolated lymphoid tissue–resident DCs critical for gut immunity
While preserving tolerance toward commensals, dendritic cells (DCs) also orchestrate response against pathogens. The noncanonical RelB NF-κB pathway in DCs curbs tolerogenic Tregs in the intestine. Wh...
Profile of Morris Moscovitch
Morris Moscovitch’s five-decade career has reshaped scientists’ understanding of how the brain stores and retrieves memories. His Multiple Trace Theory challenged the view that the hippocampus serves...
Comparative archaeology reveals recurrent but nondeterministic pathways through complexification
The amount of variation observed among early complex societies has challenged efforts to understand their social dynamics. We advocate for a comparative approach that directly investigates the forces...
An expanded apolipoprotein D family provides spider mites with dual-layer protection against dietary oxidative stress
Plant defense has driven the evolution of species-dependent adaptive strategies in many herbivores, but the molecular mechanisms of adaptation in most arthropods remain largely unknown. The two-spotte...
Mitochondrial pearling is controlled by the inner membrane and mediates segregation of the luminal content and membrane scission
Membrane pearling, the transformation of a smooth tubule into a chain of bead-like swellings connected by narrow membrane tethers, is a widely observed shape change. While it has been well studied for...
Depletion-induced interactions modulate nanoscale protein diffusion in polymeric crowder solutions
Macromolecular crowding plays a crucial role in modulating protein dynamics in cellular and in vitro environments. Polymeric crowders such as dextran and Ficoll are known to induce entropic forces, in...
Developmental changes in memory structure and precision alter the use of retrieved episodes during decisions for reward
Most widely studied option evaluation strategies rely on knowledge accumulated across repeated experiences. But how should options be evaluated in unfamiliar environments, in which knowledge is sparse...
The floral illusion: A parasitic beetle mimics the scent of flowers to attract bees
Animals are not known to biosynthesize floral chemical signals to manipulate pollinators, although such mimicry could profoundly shape plant–pollinator interactions. Larvae of the poisonous European b...
Long-horizon associative learning as a unifying framework for statistical learning across scales
Sensory inputs are rich with temporal patterns that unfold across multiple timescales. Uncovering these regularities is essential for anticipating future events and navigating the environment efficien...
An antibody–drug conjugate active against antibiotic-resistant <i> <i>Neisseria</i> gonorrhoeae </i>
Neisseria gonorrhoeae is the causative agent of gonorrhea, a sexually transmitted infection which is rising in incidence, with increasing...
Balanced polymorphism in a floral transcription factor underlies the ancient rhythm of daily sex alternation in avocado
In avocado and certain wild relatives in Lauraceae, a highly synchronized daily rhythm of floral sex timing promotes cross-pollination between two hermaphroditic flowering types. A-type plants present...
Structures of the sodium-coupled phosphate importer SLC34A2 reveal a distinct architecture and gating mechanism
Dysregulation of inorganic phosphate (Pi) homeostasis contributes to metabolic disease, cancer, pathological calcification, and kidney disease. Systemic phosphate balance is regulated by SLC34 transpo...
Parenthood decisions in uncertain times: Experimental evidence from four countries
Fertility rates are declining across much of the globe, yet the forces driving this decline have become increasingly complex, and classic theories have become less adequate to explain recent trends. W...
Treating language contact as normal: Coalescent-theoretic modeling of the prehistory of the Bantu language family
The Bantu language family of sub-Saharan Africa is among the largest in the world by the number of languages, by geographical extent, and by the number of speakers. The expansion of the Bantu language...