Proceedings of the National Academy of Sciences
Articles in this Issue
A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis
Munc13 family proteins are crucial for the secretion of neurotransmitters and hormones necessary for cell communication. They share a conserved C-terminal region that includes C 2...
Subfossil bald cypress trees suggest localized, enduring effects of major climatic episodes on the Southeast Atlantic Coast of the United States
Bald cypress ( Taxodium distichum ) is the longest-lived tree species in Eastern North America, but coastal cypress forests are vulnerable to a range of environ...
Route of fire: Pregame rituals and emotional synchrony among Brazilian football fans
Sporting events are powerful social phenomena that extend beyond the game itself, offering a unique lens to study collective emotional dynamics. We examine emotional alignment among football fans duri...
Eradication efforts catalyze rapid evolution in an invasive predatory fish
Species invasions spur costly and labor-intensive control efforts, yet even local eradication is seldom achieved. When control measures are initially effective, they may drive evolutionary adaptation...
Protein kinase A signaling regulates immune evasion by shaving and concealing fungal β-1,3-glucan
Fungal pathogens infect billions and kill millions of people each year. Many of these pathogens have evolved strategies to evade our antifungal immune defenses. Candida albicans,...
Cross-species modeling of plant genomes at single-nucleotide resolution using a pretrained DNA language model
Interpreting function and fitness effects in diverse plant genomes requires transferable models. Language models (LMs) pretrained on large-scale biological sequences can capture evolutionary conservat...
China’s SO <sub>2</sub> emission reductions enhance atmospheric ozone–driven sulfate aerosol production in East Asia
Reduction of China’s SO 2 emissions has been found to nonlinearly decrease the atmospheric sulfate (SO 4 2−...
Conformation-specific synthetic intrabodies modulate mTOR signaling with subcellular spatial resolution
Subcellular compartmentalization is integral to the spatial regulation of mechanistic target of rapamycin (mTOR) signaling. However, the biological outputs associated with location-specific mTOR signa...
Prospects for cereal self-sufficiency in sub-Saharan Africa
Sub-Saharan Africa (SSA) has the world’s largest projected increase in demand for food. Increased dependence on imports makes SSA vulnerable to geopolitical and economic risks, while further expansion...
Global health and climate benefits from walking and cycling infrastructure
We use a globally consistent dataset—Google Environmental Insights Explorer—to quantify how urban form and transport infrastructure affect walking and cycling rates in 11,587 cities from 121 countries...
Sleep deficiency exacerbates periodontal inflammation via trigeminal TRPV1 neurons
Periodontitis, a prevalent chronic inflammatory disease, profoundly impacts both quality of life and overall health. Clinical studies have suggested a correlation between periodontitis and sleep defic...
Motor-driven microtubule diffusion in a photobleached dynamical coordinate system
A hallmark feature of active matter systems is the ability of individual elements to interact and organize over length scales exceeding that of the constituent molecular players. However, the nature o...
PARP12-mediated mono-ADP-ribosylation as a checkpoint for necroptosis and apoptosis
Necroptosis and apoptosis are two alternatively regulated cell death pathways. Activation of RIPK1 upon engagement of TNFR1 by TNFα may promote necroptosis by interacting with RIPK3 or apoptosis by ac...
Dual-laser “808 and 1,064 nm” strategy that circumvents the Achilles’ heel of photothermal therapy
Breast cancer has now overtaken lung cancer as the “world’s leading cancer,” yet detecting and implementing effective therapies remains a significant challenge. Substantial advances have been made in...
Preacclimatization and base excess rather than deficit?
Reply to Kleinsasser and Burtscher: Superimposed acclimatization and adaptation to low and high altitudes in highlanders compared to lowlanders
Correction for Feng et al., Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis
Correction for Rufin et al., To enhance sustainable development goal research, open up commercial satellite image archives
Carbon and oxygen isotope evidence for a protoplanetary disk origin of organic solids in meteorites
Macromolecular organic solids found in primitive meteorites were the main source of carbon delivered to forming planets in the early Solar System. However, the conditions under which this material for...
Correction for Izdebski et al., Unbalanced social–ecological acceleration led to state formation failure in early medieval Poland
Measuring historical pollution: Natural history collections as tools for public health and environmental justice research
Through the industrial era, pollutants have been unevenly distributed in the environment, disproportionately impacting disenfranchised communities. Redressing the unequal distribution of environmental...
Reply to Larsen and Riisgård: Fluid dynamics of choanocyte chambers
The pumping function of sponge choanocyte chambers
Correction for Yuan et al., Molecular mechanism and functional significance of Wapl interaction with the Cohesin complex
Continuous self-repair protects vimentin intermediate filaments from fragmentation
Intermediate filaments are key regulators of cell mechanics. Vimentin, a type of intermediate filament expressed in mesenchymal cells and involved in migration, forms a dense network in the cytoplasm...