Proceedings of the National Academy of Sciences
Articles in this Issue
Nature’s antivenom: Combinations of conserved rattlesnake serum metalloproteinase inhibitors block the lethal action of viper venoms
Snakebite maims or kills several hundred thousand people each year. For more than a century, treatment has relied on antivenoms derived from animals immunized with whole venoms, but their efficacy, sa...
Accelerating <i>Campylobacter</i> zoonosis in the Anthropocene
Intensive poultry farming has transformed global bird populations, concentrating billions of chickens into dense industrial systems that fundamentally reshape ecological space. As birds are important...
Global threat exposure of islands in a changing world
Islands are at the forefront of global environmental change. Biological invasions, land-use change, and climate change are driving population declines and causing irreversible losses in island ecosyst...
A wearable patch for continuous levodopa monitoring in sweat: Towards exertion and power-free pharmacodynamic assessment in Parkinson’s disease
Precision management of Parkinson’s disease (PD) requires frequent levodopa (L-dopa) dose adjustments, yet current monitoring relies on subjective symptom reporting and infrequent blood testing. Here,...
Energy prioritization and neurometabolic scaling in a social insect brain
Brains are metabolically costly and due to their high energetic demands may receive priority under conditions of reduced energy availability. Such preferential energy allocation to the brain has been...
Rapid acceleration of ice-cover loss from Northern Hemisphere lakes above critical air temperature thresholds
Widespread declines in lake-ice cover are a hallmark of climate warming, yet the dynamic sensitivity of ice cover to thermal forcing remains poorly understood across broad climatic gradients. By analy...
Digestion-resistant proteins support the healthy metabolite profiles associated with plant-based diets
Plant-based diets are associated with both positive health outcomes and a diverse gut microbiome. Such diets alter the microbiome’s metabolic outputs, including increasing phenylalanine-derived phenol...