Proceedings of the National Academy of Sciences
Articles in this Issue
Institutional dynamics produce resource curse traps
Communities reliant on extractive industries face a paradox: Despite the promise of economic growth from lucrative, well-paying industries, they often experience poor socioeconomic outcomes. While the...
Rotational 3D printing of active–passive filaments and lattices with programmable shape morphing
Natural filaments, such as proteins, plant tendrils, octopus tentacles, and elephant trunks, can transform into arbitrary three-dimensional shapes that carry out vital functions. Their shape-morphing...
Novel Knotted Solenoid fold with order-shifted coil arrangement leads to nontrivial 3 <sub>1</sub> topology
Herein, we present crystal structures of proteins adopting a fold not identified among known β...
Cohesin acetylation and ATPase activity control cohesion and loop architecture through distinct mechanisms
Cohesin is a conserved protein complex that mediates sister chromatid cohesion, chromosome condensation, gene regulation, and DNA repair. These processes rely on cohesin’s ability to tether DNA and fo...
How parenthood affects the economic consequences of separation for women in same-sex and different-sex couples
Women in different-sex couples experience larger economic losses after separation than men, largely due to unequal divisions of paid and unpaid work. Women in female same-sex couples divide paid and u...
Stretchable large-area transparent nanowire composite arrays for label-free multimodal interrogation of cardiac physiology
Simultaneous interrogation of cardiac electrophysiological and metabolic processes is essential for investigating and treating heart disease. Key challenges remain in creating stretchable multimodal b...
Interspecies interaction controls <i>Escherichia coli</i> growth in human gut microbiome samples
Gut microbial community composition varies from one person to another. Potentially, this means the ecological interactions experienced by individual strains or species also vary among microbiomes of d...
Self-cleavage-dependent and -independent functions of <i>Adgrg1/Gpr56</i> in mice
Adhesion G protein–coupled receptors (AGPCRs) regulate essential physiological processes through interactions between their ectodomains and adjacent cell surface proteins or extracellular matrix compo...
The intestinal microbiota impacts nutritional immunity and resistance to <i>Acinetobacter baumannii</i> pneumonia
Broad-spectrum antibiotics are frequently administered to intensive care unit patients as part of empiric care. This treatment has been associated with subsequent infections by the emerging nosocomial...
Simple biological controllers drive the evolution of soft modes
Biological systems, with many interacting components, face high-dimensional environmental fluctuations, ranging from diverse nutrient deprivations to toxins, drugs, and physical stresses. Yet, many bi...
Targeting the polyene chain represents an adjuvant strategy for optimizing polyene antifungals
Polyene antifungals (PAs) have long constituted an irreplaceable lifesaving treatment for lethal fungal infections. However, PAs induce significant dose-dependent nephrotoxicity, primarily because of...
Hepatitis B virus covalently closed circular DNA formation in murine hepatic cells uncovers a late entry block
Chronic hepatitis B virus (HBV) infection affects nearly 300 million people worldwide. Progress in understanding HBV immunopathogenesis and developing curative therapies has been hindered by the lack...
Müller glia–microglia cross talk reprograms the Müller glia transcriptome for cell division–related processes during retina regeneration
In the zebrafish retina, Müller glia (MG) respond to retinal injury by dividing and producing a multipotent progenitor for retinal repair. This cell division is regulated by microglia; however, the un...
Distinct system-level computations underlie perceptual variation across the visual field
Human visual perception for basic dimensions varies with eccentricity and polar angle, influencing daily activities such as reading, searching, and scene perception. We investigated whether and how sy...
Emergence of genetic sex determination in an environmentally sex-determined animal
The evolution of genetic sex determination (GSD) from environmental sex determination (ESD) remains a fundamental issue in evolutionary biology. However, the mechanisms driving the transition, particu...
Long-lived polaritonic coherence and polaron decoupling effects in 2D electronic spectra
Molecular polaritons, formed by coupling molecular excitons with cavity photons, offer a promising platform for exploring quantum phenomena. A key challenge is understanding how these hybrid states ma...
Trk1 potassium transport is crucial for effective <i>Candidozyma auris</i> skin colonization
The recently emergent fungal pathogen Candidozyma (Candida) auris has produced numerous outbreaks of invasive disease in hospitals worldwide. It is the first fu...
Cell-type-resolved transcriptomic landscape of human focal cortical dysplasia
Focal cortical dysplasia (FCD) is a major cause of drug-resistant epilepsy and displays substantial clinical and histopathological heterogeneity, yet the cellular and molecular bases underlying this d...
Uncoupling neocortical neuron fate and migration via a Let-7–RBX2 axis
Throughout the central nervous system, the fate and migration of projection neurons (PNs) are tightly coordinated to ensure that specific neuronal fates settle in precise spatial locations. This is pa...
Ancient felsic sediments recycled through the deep mantle by plate tectonics
Many petrological, geodynamical, and geochemical perspectives have offered circumstantial evidence for either an early onset of plate tectonics in the first 10% of Earth’s history or a late onset afte...
Paramyxovirus infection driven by heteromultivalent sialoglycotope binding
Sialic acids (Sia) on glycoproteins and glycosphingolipids act as receptors for many respiratory viruses, including human influenza A viruses and respiroviruses, which typically bind to α2-6- and α2-3...
Amphibious passive adaptation in untethered soft robots
Mobile robots are increasingly deployed in diverse settings, ranging from logistic and household applications to ecological monitoring and operation in extreme environments. In these contexts, robots...
A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin
Daptomycin is a last resort antibiotic used to treat vancomycin-resistant enterococcal infections, but daptomycin resistance (DAP R ) arises quickly during trea...
The continuous dynamics of planning and acting in a virtually embodied task
Everyday tasks, such as selecting routes when driving or preparing meals, require making sequences of embodied decisions, in which planning and action processes are intertwined. Here, we address how p...
A parallel algorithm for the computation of the Jones polynomial
Knots, links, and entangled filaments appear in many physical systems in biology and engineering and their structural complexity is related to their function. In the context of emerging AI capabilitie...