Proceedings of the National Academy of Sciences
Articles in this Issue
Abundant fluids in southern Kumano Basin linked to fluid source and slow earthquakes at the plate boundary in the Nankai Trough
The Nankai Trough is a major subduction zone in southern Japan capable of generating the next M7 or larger earthquake off Kii Peninsula. In addition to earthquakes characterized by sharp P and S arriv...
Gaming the cancer–immunity cycle by synchronizing the dose schedules
We introduce a mathematical model of the cancer–immunity cycle and use it to test several hypotheses regarding the combination, timing, and optimization associated with chemotherapy and immunotherapy...
Phosphatidic acid production on the vacuole harboring <i>Legionella pneumophila</i> is a signal for recognition of interferon-induced GTPases
The interferon (IFN)-inducible GTPases play a crucial role in cell autonomous immunity against intracellular pathogens. Particularly, these GTPases directly recognize the host membrane-derived vacuole...
Neural and computational evidence for a predictive learning account of the testing effect
Testing enhances memory more than studying. Although numerous studies have demonstrated the robustness of this classic effect, its neural and computational origin remains debated. Predictive learning...
Refugees from Ukraine value job opportunities over welfare
Understanding refugees’ destination choices is key to designing appropriate policies, but little is known about this beyond correlational patterns and the effects of isolated policy changes. To derive...
Pervasive horizontal transfer of adeno-associated virus capsid genes
Adeno-associated viruses (AAVs) are nonpathogenic DNA viruses with potent gene delivery capabilities, making them essential tools in gene therapy and biomedical research. Despite their therapeutic imp...
Correction for Brill et al., Dissociation of SYNGAP1 enzymatic and structural roles: Intrinsic excitability and seizure susceptibility
Human eyelid behavior is driven by segmental neural control of the orbicularis oculi
The eyelid performs critical functions to protect the eye and preserve functional vision. These functions are driven by contraction of the orbicularis oculi (OO), which is a unique skeletal muscle wit...
Tracing SARS-CoV-2 clusters across local scales using genomic data
A quantitative understanding of local transmission dynamics is essential for designing effective prevention strategies. In this study, we developed a computational workflow to identify viral introduct...
Tuning Fermi liquids with polaritonic cavities
The question of whether or not passive subwavelength cavities can alter the properties of quantum materials is currently attracting a great deal of attention. In this article, we show that the Fermi l...
O-GlcNAc modulation of nuclear pore complexes orchestrates mRNA export efficiency
Efficient gene expression depends on the tightly regulated export of messenger RNA (mRNA) through nuclear pore complexes (NPCs), which are densely modified by O-linked N-acetylglucosamine (O-GlcNAc)....
CRISPR–Cas9 screening reveals microproteins regulating adipocyte proliferation and lipid metabolism
Small open reading frames (smORFs) encode microproteins that play crucial roles in various biological processes, yet their functions in adipocyte biology remain largely unexplored. In a previous study...
Cryosectioning-enhanced super-resolution microscopy for single-protein imaging across cells and tissues
DNA-points accumulation for imaging in nanoscale topography (DNA-PAINT) enables nanoscale imaging with virtually unlimited multiplexing and molecular counting. Here, we address challenges, such as var...
Discovery and development of an oral analgesic targeting the α2B adrenoceptor
Noradrenaline is a major monoaminergic neurotransmitter involved in pain modulation through an α2A-adrenergic receptor. Hence, α2-adrenergic agonists such as clonidine and dexmedetomidine exhibit anal...
Protracted circum-continent subduction: A mechanism for craton destruction and a rationale for craton longevity
The evolution of continents is shaped by the growth and destruction of long-lived cratons, which serve as their stable cores. Processes for craton destruction are controversial because most invoked me...
Hide-and-Seek genome editing reveals that Gephyrin is required for axo-axonic synapse assembly
The visualization and manipulation of proteins in neurons is widely used to deduce their functions. While every experimental approach has limitations, the concurrent knock-in and knockout of two diffe...
20E-induced <i>Kr-h1</i> expression facilitates developmental transitions depending on chromosome accessibility of <i>BR-C</i> enhancers
Transcription factors and histone modification-mediated chromatin accessibility coordinately regulate spatiotemporal expression of genes that control growth and development. It is well documented that...
Controlling transient and coupled diffusion with pseudoconformal mapping
Diffusion in physical, chemical, and biological systems often occurs under transient conditions and involves coupling across multiple physical fields, challenging conventional control methods limited...
Dipole-induced transition in 3 dimensions
The Kosterlitz–Thouless and the Hexatic phase transitions are celebrated examples of dipole (vortex, dislocation) induced transitions in condensed matter physics. For very clear reasons, these importa...
Evaluating plant growth–defense trade-offs by modeling the interaction between primary and secondary metabolism
Understanding the molecular mechanisms behind plant response to stress can enhance breeding strategies and help us design crop varieties with improved stress tolerance, yield, and quality. To investig...
Reduction of TRAF3 by heterozygosity or aging impacts B cell function
TNF receptor-associated factor 3 (TRAF3) is a signaling adaptor protein that is ubiquitously expressed but has highly distinct cell type–specific functions. TRAF3 plays critical roles in restraint of...
Quantitative and sensitive sequencing of somatic mutations induced by a maize transposon
Cells accumulate mutations throughout development, contributing to cancer, aging, and evolution. Quantitative data on the abundance of de novo mutations within plants or animals are limited, as new mu...
Fluid flow generates bacterial conjugation hot spots by increasing the rate of shear-driven cell–cell encounters
Conjugation accelerates bacterial evolution by enabling bacteria to acquire genes horizontally from their neighbors. Plasmid donors must physically encounter and connect with recipients to allow plasm...
Immiscible proteins compete for RNA binding to order condensate layers
Biomolecular condensates mediate diverse and essential cellular functions by compartmentalizing biochemical pathways. Many condensates have internal subdomains with distinct compositional identities....
The E3 ligase HECTD4 regulates COX-2-dependent tumor progression and metastasis
E3 ubiquitin ligases mediating turnover of proteins engaged in cancer progression point to key regulatory nodes. To uncover modifiers of metastatic competency, we conducted an in vivo genome-wide CRIS...