Proceedings of the National Academy of Sciences
Articles in this Issue
Cytomegalovirus disrupts Lamin A/C to control microtubule-mediated nuclear movement and cell migration
Human cytomegalovirus (HCMV) disrupts the inner nuclear Lamin A/C meshwork to facilitate virion egress. Here, we show that targeting Lamin A/C also plays a previously unrecognized role in HCMV-induced...
Lagrangian tracking reveals competing influences of clustering and turbulence on the rise velocity of bubble swarms
The rise velocity of bubble swarms is a fundamental property in many natural and industrial flows. A central question is whether clustering of bubbles enhances or suppresses their rise velocity compar...
Growth hormone regulates the stem cell population in the growth plate
Growth hormone (GH) is a key systemic regulator of longitudinal bone growth and is widely used in pediatric endocrinology, including in patients without GH deficiency. Its primary target is the growth...
The importance of local racial demographic changes in democratic erosion in the mass American public
Violent sentiment is deeply tied to racial threat from the changing racial demography of the United States. Extending the historical idea of White flight, we find shifting local racial demographic con...
Local negative frequency dependence can decrease global coexistence in fragmented populations
Most biological populations are rich in diversity, and negative frequency-dependent (NFD) selection is a well-known mechanism thought to underlie this stable coexistence of multiple variants. Recent s...
A machine learning protocol for predicting structural distributions of amyloid-forming proteins from 2D IR spectra
Protein misfolding plays a central role in diseases such as Alzheimer’s disease, Parkinson’s disease, type 2 diabetes, and transthyretin amyloidosis (ATTR), often driven by specific aggregation-prone...
A general framework for branch length estimation in Ancestral Recombination Graphs
Inference of Ancestral Recombination Graphs (ARGs) is of central interest in the analysis of genomic variation. ARGs can be specified in terms of topologies and coalescence times. The coalescence time...
Redox regulation of memory formation by Rrp1 in <i>Drosophila</i>
Long-term memory (LTM) formation requires precise gene regulation, yet the role of redox activity in this process remains poorly understood. Here, we identify Drosophila...
Lattice-decoupled rotatable stripe-like charge order within the strange metal phase of 2M-WS <sub>2</sub>
In quantum materials, charge orders typically stabilize in specific crystallographic orientations, though their formation mechanisms may vary. Here, using low-temperature scanning tunneling microscopy...
Deconstructing dynamics of symmetry breaking
The Kibble–Zurek mechanism (KZM) successfully predicts the density of topological defects deposited by the phase transitions, but it is not clear why. Its key conjecture is that, near the critical poi...
The lysosomal carrier SLC29A3 supports antibacterial signaling, and promotes autophagy by activating TRPML1 in murine dendritic cells
The solute carrier (SLC)29A3 exports nucleosides from lysosomes into the cytosol, maintaining solute homeostasis and providing metabolic intermediates for cellular processes. Loss-of-function mutation...
A balance of metabolism and diffusion articulates a gibberellin hormone gradient in the <i>Arabidopsis</i> root
The plant hormone gibberellin (GA 4 ) regulates numerous developmental processes. Within the root, GA 4 controls growth,...
Lipidomic profiling of endometrial cancer using desorption electrospray ionization mass spectrometry imaging
Novel technologies are required to improve endometrial cancer diagnosis and enhance the early detection of preinvasive precursors. Herein, desorption electrospray ionization mass spectrometry imaging...
Mechanisms of transport and analgesic compounds recognition by glycine transporter 2
Glycine transporter 2 (GlyT2) regulates inhibitory glycinergic neurotransmission, and its inhibition potentiates glycinergic signaling, which is a promising strategy for managing neuropathic pain. Thi...
Crystalline guanine: Rediscovery of a long-overlooked structure of unicellular eukaryotes
Using a mental model approach to undercut the effects of exposure to mRNA vaccination misconceptions: Two randomized trials
Although messenger RNA (mRNA) technology revolutionized vaccine creation, its use is threatened by unwarranted fear that DNA left over from the vaccine manufacturing process could integrate into recip...
GWAS for behavioral traits in golden retrievers identifies genes implicated in human temperament, mental health, and cognition
Dogs display temperamental and behavioral variation between individuals, just as psychiatric, temperamental, and cognitive traits vary in humans. In both species, these traits are highly heritable, ye...
Mating system of free-ranging domestic dogs and its consequences for dog evolution
The polygamous mating system of free-ranging domestic dogs (FRDs) contrasts with the social monogamy typical of gray wolves and all other wild canids. The transition to polygamy in dogs could have bee...
Climate warming reduces soil gaseous nitrogen losses in a temperate forest
Global warming is projected to accelerate ecosystem nitrogen (N) loss via gaseous pathways, thereby decreasing N availability, a critical nutrient for primary productivity and carbon sequestration. Ho...
The impacts of European arrival on Australian dingoes
The European colonial expansion had dramatic consequences on both Indigenous Peoples and local fauna. In Australia, the degree to which the arrival of Europeans and their dogs impacted the ecology and...