Proceedings of the National Academy of Sciences
Articles in this Issue
Sugar caps protect mRNAs from decay
Inhibition of fusidic acid resistance through restricting conformational flexibility in domain III of EF-G
Fusidic acid (FA) is one of few remaining antibiotics active against Methicillin-resistant Staphylococcus aureus . FusB confers resistance to FA by rescuing the...
Overestimated natural biological nitrogen fixation translates to an exaggerated CO <sub>2</sub> fertilization effect in Earth system models
CO 2 fertilization of the terrestrial biosphere is limited by nitrogen. Biological nitrogen fixation (BNF) is the dominant natural nitrogen source to the terres...
Woodlands of Antiquity: A millennium of dendrochronological data on forest exploitation and timber economy between the Alps and the Atlantic
The Roman Empire dominated large parts of western and central Europe for over half a millennium, leaving a lasting cultural imprint on the continent. In the densely forested regions north of the Alps,...
Large drainage systems produced half of Mars’ ancient river sediment
Large, continental-scale drainage systems occupy nearly half of Earth’s land, shaping diverse ecosystems, with their activity primarily driven by climate and tectonism. Here, we investigate whether Ma...
Neuroplastin-55 is a receptor of Manf and protects against diet-induced obesity by promoting adipose browning
The browning of white adipose tissue (WAT) enhances thermogenesis and holds great potential in obesity treatment. Membrane receptors have been proven as essential factors during WAT browning. In this...
Correction for Foley et al., Single-nuclei sequencing of uterine serous carcinoma reveals racial differences in immune signaling
Photoemission electron microscopy for connectomics
Photoemission electron microscopy (PEEM) offers a potential third modality for large-volume connectomics alongside transmission electron microscopy (TEM) and scanning electron microscopy (SEM). We ima...
Multipotent progenitors with distinct origins, clonal lineage fates, transcriptomes, and surface markers yield two hematopoietic trees
Multipotent progenitors (MPP) are the quantitative source of native hematopoiesis that have been thought to be replenished slowly by hematopoietic stem cells (HSC). However, recent fate mapping studie...
Skyrmions with multiple topological charges as orbital angular momentum encoders
Magnons carrying intrinsic orbital angular momentum (OAM) hold great potential for orbitronics, optics, and communications, but the generation of such magnons poses great challenges. In this work, we...
A 120-y time series of genomes reveals the consequences of closed breeding in German Shepherd Dogs
Many contemporary breed dogs display reduced genomic health compared to mixed-breed dogs, including reduced heterozygosity and increased genetic load, likely due to strong directed breeding. Lack of h...
Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography
Cryoelectron tomography (cryo-ET) enables three-dimensional visualization of molecular structures within tissue and intact cells, providing a powerful tool for studying the spatial organization of bio...
Retraction for Kelly et al., Monolayer purification: A rapid method for isolating protein complexes for single-particle electron microscopy
Combinatorial asymmetric acoustic metamaterials with real-time programmability
Metamaterials can stretch the envelope of attainable material properties giving rise to negative effective dynamical parameters. Metamaterials usually achieve such superior functionality through hard-...
The molecular-level diagenetic clock of sinking marine organic matter
The marine biological carbon pump is driven by sinking particulate organic matter (POM). Sinking speed and remineralization rate determine flux attenuation in the mesopelagic. Since the fate of all ma...
Correction for Cai et al., SLC39A8-mediated zinc dyshomeostasis potentiates kidney disease
Elevated risk of infectious diseases in adulthood after prenatal or early postnatal exposure to the Great Chinese Famine
Although prenatal exposure to famine is known to increase the risk of various noncommunicable conditions, its effects on infectious diseases remain poorly understood. We examined the effect of prenata...
Protein kinase A fuels positive feedback loops during Th1 cell differentiation
Imputation of ancient canid genomes reveals inbreeding history over the past 10,000 years
The multi-millennia-long history between dogs and humans has placed them at the forefront of archaeological and genomic research. Despite ongoing efforts including the analysis of ancient dog and wolf...
Cartesian equivariant representations for learning and understanding molecular orbitals
Qualitative and quantitative orbital properties such as bonding/antibonding character, localization, and orbital energies are critical to how chemists understand reactivity, catalysis, and excited-sta...
QnAs with Jane E. Parker
Evidence of an enhanced near-surface ozone layer at tropical latitudes on Mars
Ozone plays a key role in both atmospheric and near-surface chemistry, as well as in UV absorption in planetary atmospheres. Here, we report observations of ozone from the surface of another planet, u...
Contrasting melt regime in the Ice Grounding Zone of Thwaites Glacier, West Antarctica
The contribution of Thwaites Glacier, Antarctica, to sea level rise is influenced by how quickly warm salty seawater of Circumpolar Deep Water origin melts basal ice near its grounding line. Satellite...
The first preserved nasal cavity in the human fossil record: The Neanderthal from Altamura
The nose of Neanderthals and its possible adaptation to harsh climatic conditions is a longstanding matter of debate in paleoanthropology. Here, we present and describe the complete inner nasal struct...
A quantitative risk assessment framework for mortality due to macroplastic ingestion in seabirds, marine mammals, and sea turtles
Plastic ingestion has been documented in nearly 1,300 marine species, including every seabird family, marine mammal family, and sea turtle species. Acute mortality, due to obstruction, perforation, or...