Journal of Neuroscience
Articles in this Issue
Distinct Hippocampal Subfield Representational Shifts Underlie Category Exception Learning
When we encounter an exception to our prior category knowledge, such as a leaf-like butterfly that perceptually diverges from the butterflies we commonly see, we must update our knowledge to reconcile...
Brain-Selective Estrogen Therapy in Male and Female Marmosets Partially Counteracts the Adverse Effects of Aromatase Inhibition on the Brain and Behavior
Blocking estrogen synthesis via aromatase inhibition helps prevent the recurrence of estrogen receptor-positive breast cancer but also results in cognitive, sleep, and thermoregulatory disturbances. T...
KIASORT: Knowledge-Integrated Automated Spike Sorting for Geometry-Free Neuron Tracking
Modern high-density neural recordings demand spike-sorting algorithms that can handle diverse probe geometries and complex, neuron-specific drift, yet existing methods often rely on rigid geometric as...
Infra-slow (<0.1 Hz) Modulation of Human Brain Pulsations in Awake and Sleep States
The human brain exhibits three propagating pulsations, namely, cardiovascular, respiratory, and infra-slow fluctuations (ISFs <0.1 Hz), which are thought to contribute to the flow of intracranial f...
Neural Substrates of Approach–Avoidance Control in Motivational Conflict
Adaptive behavior requires control over automatic tendencies to approach reward and avoid threat. Dysregulation of this control characterizes disorders such as anxiety or addiction, yet the underlying...
Nanoparticle Modulation of Immune and Vascular Microenvironment Dynamics Following Spinal Cord Injury
Trauma to the spinal cord initiates an inflammatory response causing secondary damage, which collectively can result in loss of function below the level of the injury. The unbalanced risk–benefit rati...
Cell-Type-Specific Synaptic Scaling Mechanisms Differentially Contribute to Associative Learning
Excitatory synaptic scaling regulates network dynamics by proportionally adjusting excitatory synaptic strengths after sensory perturbations. During associative learning, blocking excitatory scaling i...
The Lateral Habenula to Ventral Tegmental Area Pathway Is Required for Aversive Learning and Defensive Behaviors
Threatening situations require animals to rapidly select appropriate defensive strategies, either disengaging behavior to avoid harm or engaging actions that allow escape or avoidance. The lateral hab...
The Dendrites Decide: Divergent Computation Strategies Define Prefrontal Layer 5 Pyramidal Subtypes
Mast Cells in the Developing Brain
Brain development requires the coordination of numerous cell types including neurons, glia, and immune cells. Mast cells (MCs) are tissue-resident innate immune cells canonically known for their role...
Erratum: L'Episcopo et al., “Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson's Disease Involves Cross Talk between Inflammatory and Wnt/β-Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair”
Erratum: Yao et al., “Estrogen Regulates Bcl-w and Bim Expression: Role in Protection against β-Amyloid Peptide-Induced Neuronal Death”
Low-Intensity Transcranial Ultrasound Stimulation Improves Motor Behavior and Modulates Cortical Functional Network Connectivity in Mice with Ischemic Stroke
The recovery of motor function in patients with ischemic stroke is closely related to the plastic remodeling of cortical functional networks. Low-intensity transcranial ultrasound stimulation (TUS) ha...
Multi-network Topology Underlying Individual Language Learning Success
Adult language learning varies widely among individuals, with some learners quickly acquiring knowledge and skills while others struggle with specific components or overall proficiency despite similar...