Journal of Neuroscience
Articles in this Issue
Takeaways from the First Year of Open Peer Review at <i>JNeurosci</i>
The Journal of Neuroscience launched an open peer review (OPR) initiative in late 2023 to enhance transparency and accountability in scientific publishing. Analysis of 740 manuscripts and 1,490 review...
Connectivity Profile and Function of Uniquely Human Cortical Areas
Determining the brain specializations unique to humans requires directly comparable anatomical information from other primates, especially our closest relatives. Human ( Homo sapie...
Response of Neuronal Populations to Phase-Locked Stimulation: Model-Based Predictions and Validation
Modulation of neuronal oscillations holds promise for the treatment of neurological disorders. Nonetheless, conventional stimulation in a continuous open-loop manner can lead to side effects and subop...
Frontostriatal Networks Undergo Functional Specialization during Adolescence That Follows a Ventral–Dorsal Gradient: Developmental Trajectories and Longitudinal Associations
Seminal studies in animal neuroscience demonstrate that frontostriatal circuits exhibit a ventral–dorsal functional gradient to integrate neural functions related to reward processing and cognitive co...
Rapid and Stimulus-Specific Deviance Detection in the Human Inferior Colliculus
Auditory deviance detection, the neural process by which unexpected stimuli are identified within repetitive acoustic environments, is crucial for survival. While this phenomenon has been extensively...
Hippocampal Place Cell Sequences Are Impaired in a Rat Model of Fragile X Syndrome
Fragile X syndrome (FXS) is a neurodevelopmental disorder that can cause impairments in spatial cognition and memory. The hippocampus is thought to support spatial cognition through the activity of pl...
Molecular and Anatomical Strengthening of “Winner” Climbing Fiber Synapses in Developing Mouse Purkinje Cells
Neural circuits are refined by strengthening frequently used or advantaged synapses while eliminating redundant connections. In neonatal mice, cerebellar Purkinje cells (PCs) are initially innervated...
Dorsal-Ventral Reinforcement Learning Network Connectivity and Incentive-Driven Changes in Exploration
Probabilistic reinforcement learning (RL) tasks assay how individuals make decisions under uncertainty. The use of internal models (model-based) or direct learning from experiences (model-free), and t...
Brain-Wide Impacts of Sedation on Spontaneous Activity and Auditory Processing in Larval Zebrafish
Despite their widespread use, we have limited knowledge of the mechanisms by which sedatives mediate their effects on brain-wide networks. This is, in part, due to the technical challenge of observing...
The Medial Olivocochlear Efferent Pathway Potentiates Cochlear Amplification in Response to Hearing Loss
The mammalian cochlea receives efferent feedback from the brain. Many functions for this feedback have been hypothesized, including on short timescales, such as mediating attentional states, and long...
Ultra-high Field fMRI Reveals Effect of Ketamine on Vocal Processing in Common Marmosets
Auditory deficits are a well-known symptom in neuropsychiatric disorders such as schizophrenia. The noncompetitive N -methyl- d -aspartate receptor antagonist ketamine has been used to model sensory a...
Sleep Modulates Neural Timescales and Spatiotemporal Integration in the Human Cortex
Spontaneous neural dynamics manifest across multiple temporal and spatial scales, which are thought to be intrinsic to brain areas and exhibit hierarchical organization across the cortex. In wake, a h...
Distributed Intracranial Activity Underlying Human Decision-making Behavior
Value-based decision–making involves multiple cortical and subcortical brain areas, but the distributed nature of neurophysiological activity underlying economic choices in the human brain remains lar...
The Serotonergic Dorsal Raphe Promotes Emergence from Propofol Anesthesia in Zebrafish
The mechanisms through which general anesthetics induce loss of consciousness remain unclear. Previous studies have suggested that dorsal raphe nucleus serotonergic (DRN 5-HT ) neurons are involved in...
Projection Motifs and Wiring Logic of Medial Pulvinar Thalamocortical Axons in the Marmoset Monkey
The medial pulvinar thalamic nucleus (MPu) is an evolutionary novelty of the primate thalamus, prominently expanded in humans. Piecemeal data from studies in various monkey species indicate that MPu a...
MuSK Regulates Neuromuscular Junction Nav1.4 Localization and Excitability
The neuromuscular junction (NMJ) is the linchpin of nerve-evoked muscle contraction. Broadly, the NMJ transduces nerve action potentials into muscle fiber action potentials (MFAPs). Efficient neuromus...