Journal of Neuroscience

Metallothionein III Mediates Ca ²⁺ -Dependent Zn ²⁺ Spikes to Inhibit Dendritic Arborization

Zinc is crucial for neuron function, but whether and how labile zinc ion (Zn 2+ ) acts as an intracellular signaling molecule remains unclear. In this work, we investigate the relationship between Ca...

Stereoelectroencephalography Reveals Neural Signatures of Multisensory Integration in the Human Superior Temporal Sulcus during Audiovisual Speech Perception

Human speech perception is multisensory, integrating auditory information from the talker's voice with visual information from the talker's face. BOLD fMRI studies have implicated the superior tempora...

Phasic Alertness Impairs Cognitive Control by Amplifying Competition between Evidence Accumulators

Although phasic alertness generally benefits cognitive performance, it often increases the impact of distracting information, resulting in impaired decision-making and cognitive control. However, it i...

Competition between Tool and Hand Motion Impairs Movement Planning in Limb Apraxia

Tool use is a complex motor planning problem. Prior research suggests that planning to use tools involves resolving competition between different tool-related action representations. We therefore reas...

Layer 6 Corticothalamic Neurons Induce High Gamma Oscillations Through Cortico-cortical and Cortico-thalamo-cortical Pathways

Layer 6 corticothalamic (L6CT) neurons project to both cortex and thalamus, inducing multiple effects including the modulation of cortical and thalamic firing, and the emergence of high gamma oscillat...

Large-Scale Color Biases in the Retinotopic Functional Architecture Are Region Specific and Shared across Human Brains

Despite the functional specialization in visual cortex, there is growing evidence that the processing of chromatic and spatial visual features is intertwined. While past studies focused on visual fiel...

Competitive Cortical Prioritization Emerges for Trained Objects across the First Year of Life

Learning to detect and recognize a broad range of visual objects is a crucial developmental task during the first year of life. However, many of the neurophysiological changes underlying the emergence...

Network Activity Shapes Inhibitory Synaptic Development in the Mouse Hippocampus

The proper development of excitatory/inhibitory (E/I) balance is critical for brain function, as any imbalance has been associated with myriad neuropsychiatric disorders. How this balance evolves duri...

Marmoset Anterior Cingulate Area 32 Neurons Exhibit Responses to Presented and Produced Calls during Naturalistic Vocal Communication

Vocal communication is a complex social behavior that entails the integration of auditory perception and vocal production. Both anatomical and functional evidence have implicated the anterior cingulat...

How the Ventromedial Prefrontal Cortex (VMPFC) Facilitates Welfare Maximization in Social Contexts

Prenatal Downregulation of CB ₁ Cannabinoid Receptors in the Mouse Prefrontal Cortex Disrupts Cortical Lamination and Induces a Transcriptional Signature Associated with Social Interaction Deficits

Endocannabinoid signaling exerts a neurodevelopmental regulatory role via CB 1 cannabinoid receptors (CB 1 Rs), which control pyramidal neuron differentiation, migration, and axonal guidance. Here, we...

Early Life Injury Alters Spinal Astrocyte Development

Neonatal injury alters synaptic transmission in the spinal superficial dorsal horn (SDH), resulting in aberrant amplification of ascending nociceptive transmission. Astrocytes orchestrate synapse deve...

Largely Intact But Less Reliable and Distributed Neural Representations of Subjective Value in Human Opioid Addiction

Addiction, particularly opioid use disorder (OUD), is often characterized by heightened propensity for risk-taking. While tolerance for risk and uncertainty varies across individuals, the elevated ris...