Journal of Neuroscience
Articles in this Issue
Mediodorsal Thalamic Input to Striatum Contributes to Early Action Learning
Action control is hypothesized to be mediated by corticothalamo-basal ganglia loops subserving the acquisition and updating of action contingencies. Within this, the mediodorsal thalamus (MD) is thoug...
Trans-synaptic Interaction with mGluR6 Contributes to ELFN1 Presynaptic Enrichment in Rod Photoreceptors
At the glutamatergic synapses between rod photoreceptors and ON-type bipolar cells (BCs), neurotransmitter is detected by the postsynaptic metabotropic glutamate receptor mGluR6. This receptor forms t...
<i>Smg5</i> Enhances Oligodendrocyte Differentiation via Nonsense-Mediated mRNA Decay of <i>Hnrnpl</i> Variant Transcripts
Nonsense-mediated mRNA decay (NMD) is a conserved RNA surveillance mechanism that degrades transcripts with premature termination codons (PTCs) and fine-tunes gene expression by targeting RNA transcri...
Presenilin Loss Impairs Synaptic Transmission and Causes Axonal Degeneration through Ryanodine Receptor Dysfunction, Independent of γ-Secretase Activity
Presenilin mutations are the most common cause of familial Alzheimer's disease (FAD), but the mechanisms by which they disrupt neuronal function remain unresolved, particularly in relation to γ-secret...
Sphingosine-1-Phosphate Signaling through Müller Glia Regulates Neuroprotection, Accumulation of Immune Cells, and Neuronal Regeneration in the Rodent Retina
The purpose of this study was to investigate how Sphingosine-1-phosphate (S1P) signaling regulates glial phenotype, neuroprotection, and reprogramming of Müller glia (MG) into neurogenic MG-derived pr...
Convergence and Segregation of Excitatory and Inhibitory Afferents in the Paraventricular Thalamic Nucleus
The paraventricular thalamic nucleus (PVT) integrates subcortical signals related to arousal, stress, addiction, and anxiety with top-down cortical influences. Increases or decreases in PVT activity e...
A Neural Signature of the Bias Toward Self-Focus
People are remarkably self-focused, disproportionately choosing to think about themselves relative to other topics. Self-focus can be adaptive, helping individuals fulfill their needs. It can also be...
IGFBP2–Ceramide Pathway Mediates Divergent Myelin Breakdown in the PNS and CNS Following Injury
Following injury, the peripheral nervous system (PNS) exhibits remarkable regenerative capacity, whereas the central nervous system (CNS) has limited regenerative potential. This difference is partial...
Moment-to-Moment Heart–Brain Interactions: How Cardiac Signals Influence Cortical Processing and Time Estimation
<i>chrna3</i> Modulates Alcohol Response
Alcohol use disorders (AUDs) are complex phenomena governed by genetics, neurophysiology, environment, and societal structures. New methods to understand the underlying neurogenetics are valuable for...
A Neural Model for V1 That Incorporates Dendritic Nonlinearities and Backpropagating Action Potentials
The work of Hubel and Wiesel has been instrumental in shaping our understanding of V1, leading to modeling neural responses as cascades of linear and nonlinear processes in what is known as the “stand...
Involvement of the Endothelial <i>N</i> -Methyl-d-Aspartate Receptor on Vessel-Associated Positioning and Differentiation of Cortical Oligodendrocytes and on Motor Activity
During cortical development, oligodendrocyte precursor (OPC) attachment and detachment to microvessels play a crucial role in their positioning and differentiation. In the developing brain, endothelia...
Forewarned Is Forearmed: The Single- and Dual-Brain Mechanisms in Detectors from Dyads of Varying Social Distance during Deceptive Outcome Evaluation
Preventing deception requires understanding how lie detectors process social information across social distance. Although the outcomes of such information are crucial, how detectors evaluate gains or...
Kappa Opioid Receptors Control a Stress-Sensitive Brain Circuit and Drive Cocaine Seeking
Stress is a potent trigger for drug-seeking behaviors in both rodents and humans with a history of substance use. Kappa opioid receptors (kORs) play a critical role in mediating stress responses. Our...