Journal of Neuroscience
Articles in this Issue
Knowledge in Animals and Machines
Drawing on philosophical theories of knowledge, I develop a conceptual framework for knowledge in animals and machines. I use this framework to engineer a new concept of large language model (LLM) kno...
Toward Unified Biomarkers for Focal Epilepsy
Accurately localizing the epileptogenic network (EpiNet) remains a major barrier to effective epilepsy treatment, largely due to limited mechanistic understanding. The EpiNet is a patient-specific bra...
ATP Release Deficiency through Astrocytic Connexin 43 in the Dorsal Hippocampus Promotes Depressive- and Anxiety-Like Behaviors
Depression is a common psychiatric disorder, and increasing evidence implicates the dysregulation of extracellular ATP and hippocampal dysfunction in its pathophysiology. However, whether ATP release...
Dissociable Pupil and Oculomotor Markers of Attention Allocation and Distractor Suppression during Listening
Emerging evidence suggests that ocular dynamics, pupil dilation, eye movements, and blinks can serve as markers of task engagement. In this study, we examined whether these measures dissociate differe...
Histone Lactylation Contributes to Neuropathic Pain by Facilitating m <sup>6</sup> A Reader Protein IGF2BP2 Expression in DRG Sensory Neurons
Histone lactylation is a novel lactate-dependent histone mark that plays an important role in regulating gene expression. However, its role in neuropathic pain remains elusive. Here, we report that Hi...
Neural Compensation in the Medial Prefrontal Cortex Preserves Self-Prioritization in Aging: A Computational Approach
Cognitive aging is characterized by widespread decline, yet certain fundamental processes show remarkable resilience. This study demonstrates that older adults (OAs; N...
Using fMRI Representations of Single Objects to Predict Multiple Objects in Working Memory in Human Occipitotemporal and Posterior Parietal Cortices
Research in visual perception has shown that in sensory areas, neural responses to a pair of objects presented together can be approximated by the linear average of the responses of each object shown...
Increased Perceptual Reliability Reduces Membrane Potential Variability in Cortical Neurons
Uncertainty is omnipresent. While humans and other animals take uncertainty into account during decision making, it remains unclear how it is represented in cortex. Recent theoretical work on uncertai...
Synergistic Geniculate and Cortical Dynamics Facilitate a Decorrelated Spatial Frequency Code in the Early Visual System
Sensory stimuli are encoded by the neuronal firing patterns they evoke in the brain. This neural code becomes less correlated as information ascends through the visual system. In the primary visual co...
Medial Frontal Theta Reduction Impairs Rule Switching via Prediction Error
Cognitive flexibility, the ability to switch behavior in response to changing rules in an uncertain environment, is crucial for adaptive decision-making. Prior research has hypothesized a key role of...
Bridging Model and Experiment in Systems Neuroscience with Cleo: The Closed-Loop, Electrophysiology, and Optophysiology Simulation Testbed
Systems neuroscience has experienced an explosion of new tools for reading and writing neural activity, enabling exciting new experiments (e.g., all-optical interrogation, closed-loop control) for int...
Noninvasive Suppression of Responses to Threat Using Focused Ultrasonic Waves
The processing of threat- and fear-related responses is known to involve the amygdala and the bed nucleus of the stria terminalis. Malignant activity in these nuclei is associated with several importa...
Cerebellar tDCS Modulates Corticocortical Functional Networks in a Regionally Specific Manner
With extensive interconnections with the cerebral cortex, the cerebellum is well positioned to coordinate communication between cortical regions. Because different cerebellar subregions interconnect w...
Muscle-Derived BMP4 Regulates Morphology and Function of Endplates on Extrafusal and Intrafusal Muscle Fibers in Adult Mice
Understanding factors contributing to neuromuscular junction (NMJ) stability postdevelopment will shed light on how this stability is lost during aging and in neuromuscular diseases. Previous work in...
Space Impacts Temporal Processing via a Visual-Dependent Spatially Organized Neural Architecture
Establishing the temporal relationship between stimuli challenges the brain, requiring some tolerance for asynchronies to form coherent representations. Based on the theory of implicit causal inferenc...