Journal of Neuroscience
Articles in this Issue
Three Fundamental Neurophysiological Features of Neural Dynamics: Aperiodic, Waveform, and Transient
The Spatiotemporal Structure of Neural Activity in Motor Cortex during Reaching
Intracortical brain–computer interfaces (BCIs) leverage knowledge about neural representations to translate movement-related neural activity into actions. BCI implants have targeted broad cortical reg...
Protein Inhibitor of Retinal Membrane Guanylyl Cyclase Rescues Mouse Rod Photoreceptors from <i>GUCY2D</i> Retinal Dystrophy
Mutations in the GUCY2D gene coding for retinal membrane guanylyl cyclase 1 (RetGC1, or GC-E) can deregulate cGMP synthesis in photoreceptors by guanylyl cyclas...
The Developmental Emergence of Tonic and Phasic REM Sleep in Rats
REM sleep is composed of two substates—phasic and tonic—that differ in their behavioral, sensory, and electrophysiological features. Although these substates are well characterized in adults, their de...
LIS1 Is Critical for Axon Integrity in Adult Mice
Mutations in human LIS1 cause lissencephaly, a severe developmental brain malformation. Although most studies focus on development, LIS1 is also expressed in adult mouse tissues. We previously induced...
Neural Representations and Functional Connections Underlie Subjective Positive Affect
Everyday experiences can evoke positive feelings that differ among individuals and guide their behavior. Although reward processing is often linked to positive feelings, the mechanisms underlying subj...
Optimal Foraging Requires Coordinating Decisions with Movements
Decision-making and motor execution are both constrained by time and energy, and their optimization depends on cost–benefit trade-offs. While many studies suggest that decisions and movements follow c...
Dendritic Inhibition Terminates Plateau Potentials in CA1 Pyramidal Neurons
In CA1 pyramidal neurons (CA1-PYRs), plateau potentials control synaptic plasticity and the emergence of place cell identity. Here, we show that dendritic inhibition terminates plateaus in an all-or-n...
Population Dynamics in Songbird RA and HVC During Learned Motor-Vocal Behavior
Complex, learned motor behaviors involve the coordination of large-scale neural activity across multiple brain regions, but our understanding of population-level neural dynamics within different regio...
Activation by Alcohol of Prefrontal Layer 5 Pyramidal Neurons Depends on Ascending Dopaminergic Input
Short-term alcohol exposure modulates activity in reward-related regions such as the ventral tegmental area (VTA) and executive cortical regions such as the prefrontal cortex (PFC), potentially contri...
Multiple Scales of Coordination along the Body Axis during <i>Drosophila</i> Larval Locomotion
Coordinated movement along the body axis is critical to locomotion. In segmented, limbless animals, anterior (head) and posterior (tail) segments play different roles in locomotion, leading to a need...
Dual Role of Microglial TREM2 in Neuronal Degeneration and Regeneration after Axotomy
Spinal cord ventral horn microglia proliferate after nerve injuries and migrate toward cell bodies of injured motoneurons (MNs) enwrapping them. The significance of this microglia reaction has remaine...
Enhanced Reticulospinal Output in Subacute Spinal Cord Injury Patients with Spasticity
In the chronic phase of spinal cord injury (SCI), damage to the reticulospinal and corticospinal tracts has been associated with the development of spasticity. Because spasticity can emerge within jus...