Journal of Neuroscience
Articles in this Issue
Social Decision Preferences for Close Others Are Embedded in Neural and Linguistic Representations
Humans frequently make decisions that impact close others. Prior research has shown that people have stable preferences regarding such decisions and maintain rich, nuanced mental representations of th...
Reduction in Reward-Driven Behavior Depends on the Basolateral But Not Central Nucleus of the Amygdala in Female Rats
Adaptive behavior depends on a dynamic balance between acquisition and extinction memories. Male and female rodents differ in extinction learning rates, suggesting potential sex-based differences in t...
Neuroscience Needs Behavioral “Wind Tunnels” for Real-Life Translation
Neuroscience has advanced rapidly over the past century by applying reductionist methods to dissect brain function at molecular, cellular, and circuit levels, primarily in animal models. While this ap...
Learning to Program “Recycles” Preexisting Frontoparietal Population Codes of Logical Algorithms
Computer programming is a cornerstone of modern society, yet little is known about how the human brain enables this recently invented cultural skill. According to the neural recycling hypothesis, cult...
Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome
Angelman syndrome (AS) is a neurogenetic disorder characterized by motor coordination and cognitive deficits. In AS, hippocampal neurons show reduced filamentous (F-)actin, a decrease we also reported...
Functional Connectivity Is Dominated by Aperiodic, Rather Than Oscillatory, Coupling
Functional connectivity (FC) has attracted significant interest in the identification of specific circuits underlying brain (dys)function. Classical analyses to estimate FC (i.e., filtering electrophy...
The Top-Down of Prefrontal Cortex to the Hippocampus Glutamatergic Pathway Regulates Reward Memory of Methamphetamine
Methamphetamine (METH) is a widely abused psychoactive drug that readily establishes reward memories contributing to METH relapse. The medial prefrontal cortex (mPFC) is central to cognition, motivati...
Common Mechanism Underlying Synaptic Dysfunction Caused by Preformed Fibril-Induced Accumulation of α-Synuclein or Tau in a Culture Propagation Model
In sporadic neurodegenerative diseases, the endogenous proteins α-synuclein in Parkinson's disease and tau in Alzheimer's disease undergo pathogenic prion-like propagation over many years, accumulatin...
Microsaccade Direction Reveals the Variation in Auditory Selective Attention Processes
Selective spatial attention plays a critical role in perception in the daily environment where multiple sensory stimuli exist. Even covertly directing attention to a specific location facilitates the...
Walking Modulates Active Auditory Sensing
Walking provides the motor foundation for navigation, while navigation ensures that walking is purposeful and adaptive to environmental contexts. Sensory processing of environmental information acts a...
Distinct Portions of Superior Temporal Sulcus Combine Auditory Representations with Different Visual Streams
In humans, the superior temporal sulcus (STS) combines auditory and visual information. However, the extent to which it relies on visual information from the ventral or dorsal stream remains uncertain...
Noninvasive Biomarkers for Assessing the Excitatory/Inhibitory Imbalance in Children with Epilepsy
Epileptic seizures involve a cortical excitation–inhibition imbalance driven by dysfunctional interneurons that contribute to gamma oscillation generation. While impaired gamma oscillations are common...
Theta Activity Supports Landmark-Based Correction of Naturalistic Human Path Integration
How do humans integrate landmarks to update their spatial position during active navigation? Using immersive virtual reality and high-density mobile EEG, we investigated the neural underpinnings of la...
TREK1 Channels Shape Spindle-Like Oscillations, Neuronal Activity, and Short-Term Synaptic Plasticity in Thalamocortical Circuits
Although TREK1 channels are widely expressed in several thalamic nuclei, the role of this K 2P family member in modulating thalamic cell excitability and physio...
Visual Distortions in Human Amblyopia Are Correlated with Deficits in Contrast Sensitivity
Amblyopia (lazy eye) is a developmental disorder of the visual cortex that causes deficits in visual acuity and shape perception. The loss of visual acuity is thought to originate from weakened cortic...