Journal of Neuroscience

Uncovering a Timescale Hierarchy by Studying the Brain in a Natural Context

As we train multiple generations of students to narrowly design clever, carefully controlled experiments in our confined lab spaces, we may fail to notice, as a field, that we have overlooked fundamen...

The Frequency and State-Dependent Relationship between Pupil Size and Respiration

Stimulus-Dependent Expression of <i>Bdnf</i> Is Mediated by ATF2, MYT1L, and EGR1 Transcription Factors

Neurotrophins like BDNF have a key role in the proper functioning of the central nervous system, influencing numerous processes like memory formation and behavior. An imbalance in BDNF levels can lead...

Kv4.2 Regulates Basal Synaptic Strength by Inhibiting R-Type Calcium Channels in the Hippocampus

Kv4.2 subunits, which mediate transient A-type K + current, are crucial in regulating neuronal excitability and synaptic responses within the hippocampus. While...

Characterizing Human Disparity Tuning Properties Using Population Receptive Field Mapping

Our visual percept of small differences in depth is largely informed by binocular stereopsis, the ability to decode depth from the horizontal offset between the retinal images in each eye. While multi...

Neurons of the Central Nucleus of the Amygdala That Express Angiotensin Type 2 Receptors Couple Lowered Blood Pressure with Anxiolysis in Male Mice

Relief from psychological stress confers cardio-protection by altering brain activity and lowering blood pressure; however, the neuronal circuits orchestrating these effects are unknown. Here, we used...

Dynamics of Pitch Perception in the Auditory Cortex

The ability to perceive pitch allows human listeners to experience music, recognize the identity and emotion conveyed by conversational partners, and make sense of their auditory environment. A pitch...

Disentangling the Component Processes in Complex Planning Impairments Following Ventromedial Prefrontal Lesions

Damage to the ventromedial prefrontal cortex (vmPFC) in humans disrupts planning abilities in naturalistic settings. However, it is unknown which components of planning are affected in these patients,...

Abnormal Local Cortical Functional Connectivity due to Interneuron Dysmaturation after Neonatal Intermittent Hypoxia

Prematurely born infants often experience frequent hypoxic episodes due to immaturity of respiratory control resulting in disturbances of cortical development and long-term cognitive and behavioral ab...

Mapping Eye, Arm, and Reward Information in Frontal Motor Cortices Using Electrocorticography in Nonhuman Primates

Goal-directed reaches give rise to dynamic neural activity across the brain as we move our eyes and arms and process outcomes. High spatiotemporal resolution mapping of multiple cortical areas will im...

Time Persistence of the FMRI Resting-State Functional Brain Networks

Time persistence is a fundamental property of many complex physical and biological systems; thus understanding the phenomenon in the brain is of high importance. Time persistence has been explored at...

The Representation of Stimulus Features during Stable Fixation and Active Vision

Predictive updating of an object's spatial coordinates from presaccade to postsaccade contributes to stable visual perception. Whether object features are predictively remapped remains contested. We s...

K _V 1 Channels Enable Myelinated Axons to Transmit Spikes Reliably without Spiking Ectopically

Action potentials (spikes) are regenerated at each node of Ranvier during saltatory transmission along a myelinated axon. The high density of voltage-gated sodium channels required by nodes to reliabl...

Scaling of Ventral Hippocampal Activity during Anxiety

The hippocampus supports a multiplicity of functions, with the dorsal region contributing to spatial representations and memory and the ventral hippocampus (vH) being primarily involved in emotional p...

From Circuits to Lifespan: Translating Mouse and Human Timelines with Neuroimaging-Based Tractography

Animal models are commonly used to investigate developmental processes and disease risk, but humans and model systems (e.g., mice) differ substantially in the pace of development and aging. The timeli...

Involvement of aSPOC in the Online Updating of Reach-to-Grasp to Mechanical Perturbations of Hand Transport

Humans adjust their movement to changing environments effortlessly via multisensory integration of the effector’s state, motor commands, and sensory feedback. It is postulated that frontoparietal (FP)...

Transient Upregulation of Procaspase-3 during Oligodendrocyte Fate Decisions

Oligodendrocytes are generated throughout life and in neurodegenerative conditions from brain resident oligodendrocyte precursor cells (OPCs). The transition from OPC to oligodendrocyte involves a com...