Journal of Neuroscience
Articles in this Issue
Extracellular Spike Waveforms: Morphology, Biophysics, and Classification Strategies
Extracellular spike waveforms provide critical insights into neuronal activity, morphology, and function. Their shape can reveal cell-type identity, excitatory versus inhibitory function, and afferent...
Topological Changes in Brain Networks in Subjective Cognitive Decline: Associations with Amyloid Staging and Network Adaptation
Atypical Development of Functional Brain Networks in Neonates with Congenital Heart Disease
Congenital heart disease (CHD) affects ∼1% of live births in the United States and is the most prevalent congenital disorder. Despite advances in neonatal cardiovascular surgery improving survival, ne...
Increased and Coupled ERP and fMRI Responses toward Positive Social Evaluative Feedback: An EEG–fMRI Study
Social-evaluative feedback is a key component of human social interaction, influencing self-view, behavior, and psychological well-being. This study investigates the neural mechanisms underlying socia...
Temporally Coordinated Activity among Motor Cortex, Thalamus, and Thalamic Reticular Nucleus Neurons during Rat Forelimb Movements
Thalamic reticular nucleus (TRN) neurons receive excitatory inputs from both cortical and thalamic neurons and, in turn, inhibit thalamic relay neurons, thereby modulating thalamocortical signaling. R...
The Parafascicular Role in Updating Action from a Spatial to a Visual Strategy Is Driven by Its Glutamatergic Mesencephalic Locomotor Region Inputs
The ability to update actions depends on the thalamus's parafascicular nucleus (PF); however, which PF's inputs control this function is unknown. Here, using fiber photometry, retrograde labeling, ex...
Corticotropin-Releasing Factor and Somatostatin Neurons in the Central Amygdala Mediate Dynamic Defensive Behaviors during Fear Extinction
Traumatic experiences can result in heightened fear responses to trauma-associated stimuli. These symptoms can be difficult to extinguish, so identifying neuronal targets for facilitating fear extinct...
Dopamine Dynamics in the Nucleus Accumbens Reflect Confidence in Detecting the Occurrence and Nonoccurrence of Visual Signals in Perceptual Decision-Making
Dopamine (DA) is critically involved in processes such as reward anticipation, attention, and decision-making. The present study examined the temporal dynamics of phasic DA transients in the nucleus a...
Distinct Hippocampal Mechanisms Support Concept Formation and Updating
Learning systems must constantly decide whether to create new representations or update existing ones. For example, a child learning that a bat is a mammal and not a bird would be best served by creat...
Functional Clusters for Shape, Texture, and Motion Encoding in Macaque V2
Macaque primary visual cortex (V1) exhibits exquisite columnar organization, while midlevel area V4 does not. Here we investigated the functional organization and representational bases of intervening...
The Pro- But Not Antinociceptive Effects of Cannabidiol Depend on Trpa1b in Larval Zebrafish
The promiscuous ligand cannabidiol (CBD) shows promise as an analgesic, but its complex pharmacodynamics make it difficult to identify its mechanism(s) of action. Putative CBD receptors including cann...
Early Development of Direction Selectivity in the Higher Visual Cortex
A fundamental aspect of visual motion processing is the computation of motion direction. In ferrets, as in primates, selectivity for motion direction is found both in early cortical stages like the pr...
Ribosomal Profiling of the Geniculate Ganglion Identifies the Receptor ALK as Critical for the Development and Maintenance of Oral Sensory Neurons
The geniculate ganglion (GG) consists of two populations of neurons, sensory neurons that innervate the oral cavity and express the transcription factor Phox2b...
MTCL2 Is Essential for the Bipolar-to-Multipolar Transition in the Dendrite Extension of Cerebellar Granule Neurons
The dynamic regulation of neuronal polarity is essential for the formation of neural networks during brain development. Primary cultures of rodent neurons recapitulate several aspects of this polarity...