Journal of Neuroscience
Articles in this Issue
HIV-1 gp120 Induces Nociceptive Hypersensitivity via α2δ-1–Bound NMDA Receptors at Primary Afferent→Excitatory Neuron Synapses
Human immunodeficiency virus 1 (HIV-1) infection often results in sensory neuropathy, with >60% of affected individuals developing chronic pain. Although viral proteins such as glycoprotein 120 (gp...
A Transient Feature of the Inferior Olive Supports the Development of Cerebellar Internal Models
The inferior olive (IO) supports motor learning by supplying the cerebellum with critical sensory and motor input. In adult rats, that input includes externally generated limb stimulation. In contrast...
Non-Ionotropic NMDA Receptor Signaling in Mechanistically Distinct Forms of Hippocampal Depotentiation
The reversal of learning-induced synaptic potentiation through depotentiation may be important in certain types of forgetting. Here, we evaluated how synaptic plasticity induced by different stimuli i...
Transcutaneous Auricular Vagus Nerve Stimulation during Movement Selectively Activates Motor Circuitry without Additional Cortical or Autonomic Effects
Transcutaneous auricular vagus nerve stimulation (taVNS) is a promising noninvasive neuromodulation technique with growing therapeutic relevance. Although increasingly combined with physical therapy i...
Elaboration of Cortical Pyramidal Dendrites Requires Dephosphorylation of Signal Regulatory Protein α by Protein Tyrosine Phosphatase δ
Protein tyrosine phosphatase δ (PTPδ) is involved in Sema3A-induced dendritic elaboration of cortical pyramidal neurons through the activation of Fyn tyrosine kinase. However, the in vivo substrates o...
Neural Correlates of Visuomotor Co-regulation in Social Synchronization
During social activities, people coordinate their movements by exchanging visuomotor information. Interpersonal coordination arises from two complementary processes, involving either voluntary (planne...
Selective Encoding of Priors for Flexible Categorization But Not Bayesian Inference in the Frontal Eye Field
Expectations or prior beliefs about the world modulate sensory processing at the behavioral and neural levels. Bayesian models predict that such priors compensate for input uncertainty to optimize sen...
GluN3A Is Required for Coordinated Postnatal Development of Axonal and Dendritic Branching Patterns in Mouse L2/3 Callosal Projection Neurons
Callosal projections connect both cortical hemispheres via the corpus callosum, allowing bilateral integration of sensory information. Callosal axons originate mainly from layer (L)2/3 pyramidal neuro...
Acute Anxiety Selectively Enhances Value-Free Random Exploration through Frontoparietal Engagement
Motivational decision-making is most adaptive when exploitation of known rewards is effectively balanced against exploration of uncertain alternatives. Trait anxiety influences this balance across ind...
Theta Oscillations Selectively Support Attentional Exploration of Space
Attention facilitates stimulus processing by selecting specific locations (spatial attention) or features (feature-based attention). It can be sustained on a given location or feature or reoriented be...
Language-Specific Tonal Features Drive Speaker–Listener Neural Synchronization
Verbal communication transmits information across diverse linguistic levels, with neural synchronization (NS) between speakers and listeners emerging as a putative mechanism underlying successful spee...
Evolving Roles of Primary Cilia in CNS Development and Neural Circuit Function: From Human Disease to Molecular Underpinnings
Primary cilia are small organelles acting as cellular antennae that sense and transduce diverse signals, including developmental signaling pathways in the developing central nervous system (CNS). This...