Journal of Neuroscience
Articles in this Issue
Close Encounters with Art of Neuroscience 14th Edition
Neuroscience research affects individuals in diverse and profound ways, not only in the many laboratories and imaging facilities worldwide but also far beyond them. Often, these experiences inspire cr...
Neuroimaging Model of Visceral Manipulation in an Awake Rat
Reciprocal neuronal connections exist between the internal organs of the body and the nervous system. These projections to and from the viscera play an essential role in maintaining and fine-tuning or...
Phasic Dopamine Release in the Nucleus Accumbens Influences REM Sleep Timing
Based on the activity of dopamine (DA) neurons during behavioral states, the DA system has long been thought to be foundational in regulating sleep–wake behavior; over the past decade, advances in cir...
Subthalamic Nucleus Deep Brain Stimulation in the Beta Frequency Range Boosts Cortical Beta Oscillations and Slows Down Movement
Recordings from Parkinson's disease (PD) patients show strong beta-band oscillations (13–35 Hz), which can be modulated by deep brain stimulation (DBS). While high-frequency DBS (>100 Hz) ameliorat...
Policy Complexity Suppresses Dopamine Responses
Limits on information processing capacity impose limits on task performance. We show that male and female mice achieve performance on a perceptual decision task that is near-optimal given their capaci...
Cortical Encoding of Spatial Structure and Semantic Content in 3D Natural Scenes
Our visual system enables us to effortlessly navigate and recognize real-world visual environments. Functional magnetic resonance imaging (fMRI) studies suggest a network of scene-responsive cortical...
Retrieval of an Ethanol-Conditioned Taste Aversion Promotes GABAergic Plasticity in the Anterior Insular Cortex
Blunted sensitivity to ethanol’s aversive effects can increase motivation to consume ethanol; yet, the neurobiological circuits responsible for encoding these aversive properties are not fully underst...
Cortex-Specific <i>Tmem169</i> Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice
The development of the nervous system is a complex process, with many challenging scientific questions yet to be resolved. Disruptions in brain development are strongly associated with neurodevelopmen...
Voxel-Based Lesion–Symptom Mapping Localizes Residual Visual Function in Hemianopia
Damage to the primary visual cortex (V1) results in visual field deficits on the contralateral side of the world corresponding to the damaged region. Patients with such loss nonetheless show varying r...
Partially Observable Markov Models Inferred Using Statistical Tests Reveal Context-Dependent Syllable Transitions in Bengalese Finch Songs
Generative models have diverse applications, including language processing and birdsong analysis. In this study, we demonstrate how a statistical test, designed to prevent overgeneralization in sequen...
Ghrelin Recruits the Endocannabinoid System to Modulate Food Reward
Ghrelin enhances feeding by activating the growth hormone secretagogue receptor (GHSR). In the brain, GHSRs are expressed in regions responsible for regulating food motivation including the ventral te...
Amyloid-β-Driven Synaptic Deficits Are Mediated by Synaptic Removal of GluA3-Containing AMPA Receptors
The detrimental effects of oligomeric amyloid-β (Aβ) on synapses are considered the leading cause for cognitive deficits in Alzheimer's disease. However, through which mechanism Aβ oligomers impair sy...
<i>Notch1</i> is Required to Maintain Supporting Cell Identity and Vestibular Function during Maturation of the Mammalian Balance Organs
The inner ear houses both hearing and balance sensory modalities. The hearing and balance organs consist of similar cell types, including sensory hair cells and associated supporting cells. Previously...
Emergence of Categorical Representations in Parietal and Ventromedial Prefrontal Cortex across Extended Training
How do the neural representations underlying category learning change as skill develops? We examined perceptual category learning using a prototype learning task known to recruit a corticostriatal sys...