Journal of Neuroscience
Articles in this Issue
The Trials and Aspirations of an Early Career Researcher Advisory Board
Acknowledgment of Reviewers
Collaborating Reviewers
Erratum: Yao et al., “β-Amyloid-Induced Neuronal Apoptosis Involves c-Jun N-Terminal Kinase-Dependent Downregulation of Bcl-w”
Erratum: Spencer et al., “Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body Diseases”
Expression of Concern: Viscomi et al., “Selective CB2 Receptor Agonism Protects Central Neurons From Remote Axotomy-Induced Apoptosis Through the PI3K/Akt Pathway”
A Peptidergic Neural System Connects the Circadian Clock to the Photoperiodic Control of Reproductive Diapause in the Bug <i>Riptortus pedestris</i>
A diapause program that anticipates harsh seasonal environments contributes to flexible seasonal adaptation of organisms. Many animals use the photoperiod as a cue for seasonal sensing, and a circadia...
Behavioral Relevance of Early Neural Coding of Low-Level Odor Features in Humans
Understanding how the brain transforms peripheral sensory inputs into higher-level representations, and how these contribute to perception and behavioral performance, is a central question in sensory...
Prefrontal Default Mode Network Interactions with Posterior Hippocampus during Exploration
Hippocampal maps and ventral prefrontal cortex (vPFC) value and goal representations support foraging in continuous spaces. How might hippocampal–vPFC interactions control the balance between behavior...
Chemogenetic Inhibition and Optogenetic Depotentiation of the Prelimbic Cortex to Paraventricular Thalamus Pathway Attenuate Abstinence-Induced Plasticity and Heroin Seeking in Rats
Opioid use disorder (OUD) is characterized by high relapse rates, underscoring an urgent need to identify neurobiological mechanisms of opioid seeking. The paraventricular thalamus (PVT) is a key brai...
Aperiodic Activity Reflects Pathologic Waveform Shapes in Focal Epilepsy
Epilepsy constitutes a clinically manifest excitability disorder that is characterized by aberrant electrophysiological activity in the electroencephalogram (EEG). The correct identification of the se...
The Psychedelic Psilocin Suppresses Activity of Central Amygdala Corticotropin-Releasing Factor Receptor 1 Neurons and Decreases Ethanol Drinking in Female Mice
Alcohol use disorder (AUD) is a highly prevalent disorder with limited therapeutic options. The central amygdala (CeA) is a critical brain region as dysregulation within the CeA and the corticotropin-...
Switching between Newly Learned Motor Skills
Studies of cognitive flexibility suggest that switching between different tasks can entail a transient switch cost. Here, we asked whether analogous switch costs exist in the context of switching betw...
Neural Tracking of the Maternal Voice in the Infant Brain
Infants preferentially process familiar social signals, but the neural mechanisms underlying continuous processing of maternal speech remain unclear. Using EEG-based neural encoding models based on te...
Synaptic Gpr85 Influences Cerebellar-Granule-Cell Electrical Properties and Light-Induced Behavior in Zebrafish
GPR85/SREB2 is an exceptionally conserved orphan seven-transmembrane receptor with poorly understood biological function. Here, we combine genetic, imaging, transcriptomic, electrophysiological, and b...
The Bed Nucleus of the Stria Terminalis–Deep Mesencephalic Nucleus Circuit Linking Emotion and Wakefulness
The bed nucleus of the stria terminalis (BNST), a part of the extended amygdala, integrates emotional and arousal-related signals. While GABAergic BNST (GABA BNST...
Brief Encounters with Real Objects Modulate the Medial Parietal But Not Occipitotemporal Cortex
Humans are skilled at recognizing everyday objects from pictures, even if we have never encountered the depicted object in real life. However, if we have encountered an object, how does that real-worl...
Too Little and Too Much: Balanced Hippocampal, But Not Medial Prefrontal, Neural Activity Is Required for Intact Novel Object Recognition in Rats
Impaired GABAergic inhibition, so-called neural disinhibition, in the prefrontal cortex and hippocampus has been linked to cognitive deficits. The novel object recognition (NOR) task has been used wid...
Structural Plasticity of Peptidergic and Nonpeptidergic C Afferent Terminals in the Medullary Dorsal Horn during Craniofacial Inflammatory Pain
Nociceptive afferents and dorsal horn neurons undergo significant functional changes in pathological pain conditions. The structural remodeling of synapses of C afferents, which may contribute to the...
Energy Deficit Is a Key Driver of Sleep Homeostasis
Sleep and feeding—typically mutually exclusive behaviors that are vital for survival and health—are intricately linked. Across species, chronic sleep loss or deprivation is associated with increased c...
Input-Specific Organization of Intrinsic Excitability Expands Coding Capacity of Fast-Spiking Auditory Neurons
Heterogeneity of presynaptic input and postsynaptic intrinsic excitability are two major variables that regulate neuronal firing rates and patterns. Yet, little is known about how these variables inte...
A Novel Mouse Model for Developmental and Epileptic Encephalopathy by Purkinje Cell-Specific Deletion of <i>Scn1b</i>
Loss of function variants of SCN1B are associated with a range of developmental and epileptic encephalopathies (DEEs), including Dravet syndrome. These DEEs fea...
Experience-Dependent Plasticity to Visual Sequences in Mouse Anterior Cingulate Cortex Reflects Familiarity
Anterior cingulate cortex (ACC) is a prefrontal area implicated in functions including cognitive control, attention, and prediction. Mouse ACC receives input from the visual system and uses visual inf...
Dual Role of LH-GABA Neurons in Encoding Alcohol Reward and Aversive Memories
One of the core aspects of alcohol use disorder is continued use despite negative consequences. Individuals with an alcohol use disorder typically engage in behaviors which represent a failure to inte...
Medial Olivocochlear Efferent Modulation of Cochlear Micromechanics Requires P2X4 Receptor in Outer Hair Cells
The role of P2X4, one of the most abundant ionotropic purinergic receptors in the central nervous system, is explored in the context of auditory function. We observed, by using constitutive and condit...