Journal of Neuroscience
Articles in this Issue
Mammalian Brains Seen through the Lens of Evolution
This Viewpoint argues that understanding how the brain controls behavior requires an explicitly evolutionary framework. The mammalian brain did not emerge through the replacement of earlier circuits w...
Evolutionary Divergence in Dopamine Regulation between Rodents and Primates and Its Implications for Neurobiological Research
Erratum: Morishita et al., “Two-Step Actions of Testicular Androgens in the Organization of a Male-Specific Neural Pathway from the Medial Preoptic Area to the Ventral Tegmental Area for Modulating Sexually Motivated Behavior”
The S1–insula Circuit Differentially Modulates Alcohol Drinking and Aversive Behavior in Mice
Sensory processing assigns salience to environmental and internal stimuli, shaping behavior through learned associations. In alcohol use disorder (AUD), sensory cue processing is dysregulated, driving...
Controlling Spatio-Temporal Sequences of Neural Activity by Local Synaptic Changes
The neural basis of behavior is believed to consist of sequential patterns of neural activity in the relevant brain regions. Behavioral flexibility also requires neural circuit mechanisms that support...
Nuclear Factor-Y Controls Neurite Extension by Balancing BMP Signaling
Neuronal circuit formation is controlled by secreted guidance molecules and their receptors. However, the transcriptional mechanisms underlying neuronal circuit formation are not fully understood. In...
Electrophysiological Brain Connectivity and Subjective States Evoked by Electrical Stimulation of the Human Mid-thalamus
Recent developments in intracranial EEG allow direct recordings from the human thalamus, offering new insight into thalamocortical relationships in the human brain. In this study, we applied direct in...
Bright Light Shapes Diurnal Sleep–Wake Rhythms with Associated c-Fos Activity in the Anterior Paraventricular Thalamus in the Nile Grass Rat
Sleep profiles of the Nile grass rat, a day-active rodent that is widely used in research, have not been fully characterized. Sleep electroencephalograms were therefore recorded in male Nile grass rat...
Exaggerated NMDA Receptor-Primed Metaplasticity via SK Channel Dysregulation in <i>Fmr1</i> Knockout Mice
Fragile X syndrome (FXS), the most common monogenic neurodevelopmental disorder associated with autism and intellectual disability, results from the loss of expression of the X-linked...
Extracellular HSPA5/Grp78/BiP, Acting through Its Receptor Plexin-B3 and Nkx2.8, Regulates Oligodendrocyte Myelination in Mice
Myelin sheaths are generated from differentiated plasma membranes of oligodendroglial cells (oligodendrocytes) during development. Despite detailed functional studies, such as aiding nerve conduction...
High-Fidelity Backpropagation through Primate Foveal Cones
Primate vision has exceptionally high spatial acuity and contrast sensitivity. This performance originates in specialized photoreceptors of the fovea. These cones transduce light into electrical signa...
Primary Neural Degeneration after Cochlear Implantation: Histological and Electrophysiological Evidence from a Mouse Model
Patients undergoing hearing-preservation cochlear implantation (HPCI) often retain low-frequency thresholds initially, yet many develop progressive loss of residual hearing and variable speech perform...
Breathing Strategies to Influence Perception: Evidence for Interoceptive and Exteroceptive Active Sensing
Recent research indicates that humans continuously and automatically modulate their breathing to temporally align exteroceptive stimuli with specific phases of the respiratory cycle. This process has...
Faces and Word Forms Can Coexist in the Right Ventro-occipital Temporal Cortex—Evidence from Left-Hemisphere Perinatal Stroke
In most healthy adult humans, the right ventro-occipital temporal cortex (vOTC) is more involved in face perception than its left-hemisphere counterpart. Several hypotheses link this right-lateralizat...
White Matter Damage in Multiple Sclerosis Disproportionately Targets Default Mode, Executive Control, and Salience Networks
Multiple sclerosis (MS) and several other neurodegenerative disorders affect structurally and functionally connected brain networks. However, the extent of structural damage within specific networks r...