Journal of Neuroscience
Articles in this Issue
ALS and Huntington Disease: Unraveling the Connections between TDP-43 and Huntingtin
Amyotrophic lateral sclerosis (ALS) and Huntington disease (HD) are lethal neurodegenerative diseases affecting motor function. Though their etiology and pathology are distinct, recent evidence sugges...
The Frontopolar Cortex Contributes to Motivating Cognitive Effort Exertion during Adaptive Decision-Making
A Shared Theta-Rhythmic Process for Selective Sampling of Environmental Information and Internally Stored Information
Selective attention is the collection of mechanisms through which the brain preferentially processes behaviorally important information. Many everyday tasks, such as shopping for groceries, require se...
Rapid Inversion of Singleton Distractor Representations Underlies Learned Attentional Suppression
In visually complex and dynamically changing environments, humans must often filter out salient but task-irrelevant stimuli. Prior work shows that with repeated exposure to color singleton distractors...
Divergent Roles of Nucleus Accumbens D1- and D2-MSNs in Regulating Hedonic Feeding
The nucleus accumbens (NAc) is a critical node in the neural circuitry underlying reward and motivated behavior, including hedonic feeding, and its dysfunction is implicated in maladaptive behaviors i...
Heterosynaptic Interactions between the Dorsal and Ventral Hippocampus in Individual Medium Spiny Neurons of the Nucleus Accumbens Ventromedial Shell
Establishing learned associations between rewarding stimuli and the context under which those rewards are encountered is critical for survival. Hippocampal input to the nucleus accumbens (NAc) provide...
Latent Neurocognitive Mechanisms Underlying Quantity Discrimination in Children with and without Mathematical Learning Disabilities
Mathematical learning disabilities (MLD) affect up to 14% of school-age children, yet the underlying neurocognitive mechanisms remain elusive. We developed drift diffusion model with dynamic performan...
Modulation and Gating of Transthalamic and Subcortical Pathways through Somatosensory Thalamus
Higher order (HO) thalamic nuclei are characterized by receiving driver input from layer 5 (L5) of cortex and serve as a transthalamic route of corticocortical communication. These HO nuclei are also...
In Vivo Screen of Parkinson’s Disease GWAS Risk Genes Identifies <i>ARIH2</i> as a Novel Regulator of α-Synuclein Toxicity in Dopaminergic Neurons
Parkinson's disease (PD) is a late-onset neurodegenerative disease characterized by preferential degeneration of midbrain dopaminergic neurons and α-synuclein–containing Lewy bodies that are found in...
Auditory Representation of Vocal Signals in a Pallial Cortical Circuit
Knowledge of how vocal communication signals are represented in the auditory system is crucial for understanding the perceptual basis of vocal communication. Using male and female zebra finches, we id...
Novelty, Ecological Relevance, and Sexual Receptivity Modulate Neuronal Interactions between the Amygdala and Hippocampus
Many studies have demonstrated that the basolateral complex of the amygdala (BLA) can facilitate offline consolidation processes in the hippocampus. However, an open question is how online neuronal os...
A Time-Sensitive Plasticity Distinguishes the Rapid and Sustained Synaptic Actions of Ketamine from Its (2 <i>R</i> ,6 <i>R</i> )-Hydroxynorketamine Metabolite
( R , S )-Ketamine (ketamine) induces rapid and sustained antidepressant-relevant neuroplastogenic effects in vivo. The...
Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk
Economic choice entails computing and comparing the subjective values of different goods. Orbitofrontal cortex (OFC) is thought to contribute to both operations. However, previous work focused almost...
A Movement-Independent Signature of Urgency during Human Perceptual Decision-Making
How does the brain adjust its decision processes to ensure timely decision completion? Computational modeling and electrophysiological investigations have pointed to dynamic “urgency” processes that s...