Journal of Neuroscience
Articles in this Issue
µ-Opioid Receptor Control of Glutamate/GABA Coreleasing SUM and VTA Projections to the Dentate Gyrus
Erratum: Bellocchio et al., “Sustained G <sub>q</sub> -Protein Signaling Disrupts Striatal Circuits via JNK”
Abrupt and Gradual Changes in Neuronal Processing upon Falling Asleep and Awakening
The neural processes that change when falling asleep are only partially understood. At the cortical level, features of both spontaneous neural activity and sensory responses change between wakefulness...
Sustained Hippocampal Theta Oscillations Reflect Experience-Dependent Learning in Backward Temporal Order Memory Retrieval
Navigating within our neighborhood or learning a set of concepts requires remembering the relationship between individual items that are presented sequentially. Theta activity in the mammalian hippoca...
The Epigenetic Reader PHF23 Is Required for Embryonic Neurogenesis
Epigenetic mechanisms are crucial in the tightly regulated process of neurogenesis from radial glial cells (RGCs) to intermediate progenitor cells (IPCs) to neurons during embryonic brain development....
Distinct Regulation of Early Trafficking of the NMDA Receptors by the Ligand-Binding Domains of the GluN1 and GluN2A Subunits
N -Methyl- d -aspartate receptors (NMDARs) play a crucial role in excitatory neurotransmission, with numerous pathogenic variants identified in the GluN subunits, including their ligand-binding domain...
Inhibition of Rho-Associated Kinases ROCK1 and ROCK2 as a Therapeutic Strategy to Reactivate the Repressed <i>FXN</i> Gene in Friedreich Ataxia
Friedreich ataxia (FA) is an autosomal recessive disease characterized by progressive damage to the nervous system and severe cardiac abnormalities. The disease is caused by a GAA•TTC triplet repeat e...
Microglia Support Both the Singular Form of LTP Expressed by the Lateral Perforant Path and Episodic Memory
We report here that microglia exert a surprisingly discrete but functionally critical influence on synaptic plasticity in the mouse hippocampus. Treatment of adult male mice with colony-stimulating fa...
Modulation of Dopamine Neurons Alters Behavior and Event Encoding in the Nucleus Accumbens during Pavlovian Conditioning
When a cue is located away from its associated reward, some animals will learn to approach the site of reward (goal-tracking behavior) while others will approach the cue (sign-tracking behavior). The...
Anchoring Functional Connectivity to Individual Sulcal Morphology Yields Insights in a Pediatric Study of Reasoning
A salient neuroanatomical feature of the human brain is its pronounced cortical folding, and there is mounting evidence that sulcal morphology is relevant to functional brain architecture and cognitio...
Task-Switch Related Reductions in Neural Distinctiveness in Children and Adults: Commonalities and Differences
Goal-directed behavior requires the ability to flexibly switch between task sets with changing environmental demands. Switching between tasks generally comes at the cost of slower and less accurate re...
Nonlinear Dendritic Integration Supports Up–Down States in Single Neurons
Changes in the activity profile of cortical neurons are due to effects at the scale of local and long-range networks. Accordingly, abrupt transitions in the state of cortical neurons—a phenomenon know...
Phonological Representations of Auditory and Visual Speech in the Occipito-temporal Cortex and Beyond
Speech is a multisensory signal that can be extracted from the voice and the lips. Previous studies suggested that occipital and temporal regions encode both auditory and visual speech features but th...