Journal of Neuroscience
Articles in this Issue
Erratum: Koloski et al., “Beta and High Gamma Oscillations in the Cortico-striatal Network Reflect Reward Certainty on a Probabilistic Reversal Learning Task”
Erratum: Loukil et al., “Identification of New Ciliary Signaling Pathways in the Brain and Insights into Neurological Disorders”
The Retinal Light Response Is Modulated by an mGluR5-Mediated Retrograde Signal from ON-Bipolar Cells to Photoreceptors
The ON visual pathway is initiated by the deactivation of mGluR6, coupled to the opening of TRPM1 channels in retinal ON-bipolar cell dendrites. Here, we show that a second metabotropic glutamate rece...
Individual Pulvinar Neurons Integrate Cortical and Subcortical Signals
The pulvinar nucleus (PUL) has long been proposed as an integrative hub for sensory processing, but whether this integration occurs at the level of individual neurons or through parallel pathways rema...
Gyral Crowns Contribute to the Cortical Infrastructure of Human Face Processing
Neuroanatomical features across spatial scales contribute to functional specialization and individual differences in behavior across species. Among species with gyrencephalic brains, gyral crown heigh...
Frontal Vulnerability versus Temporal Resilience within the Core Language Network: Neuro-compensatory Mechanisms Underline Differential Language Aging Trajectories
Age-related decline underlies cognitive functions such as sensorimotor control, executive functioning, memory, and language production (LP), whereas language comprehension (LC) tends to remain intact...
Eye Movement-Related Eardrum Oscillations (EMREOs) Occur without Visual Input But Are Reduced during Closed Eyelids
Recent investigations have shown that the tympanic membranes exhibit synchronous oscillations with each saccadic eye movement (Gruters et al., 2018), a phenomenon known as eye movement-related eardrum...
Optimal Inhibitory-to-Excitatory Ratio Governs Slow and Fast Oscillations for Enhanced Neural Communication
Neural oscillations at distinct frequency bands facilitate communication within and between neural populations. While single-frequency oscillations are well-characterized, the simultaneous emergence o...
Effects of Novelty and Temporal Distance on Postexperience Spike Patterns of Hippocampal Place Cells Encoding Multiple Environments
The hippocampus plays a crucial role in consolidating episodic memories from diverse experiences that encompass spatial, temporal, and novel information. This study analyzed the spike patterns of hipp...
DMT-Induced Shifts in Criticality Correlate with Self-Dissolution
Psychedelics profoundly alter subjective experience and brain dynamics. Brain oscillations express signatures of near-critical dynamics, relevant for healthy function. Alterations in the proximity to...
Electrophysiological and Proteomic Evidence of Protease-Mediated Pro-nociceptive Signaling in Inflammatory Bowel Disease Patients
Abdominal pain is a debilitating symptom of inflammatory bowel disease (IBD). Despite advances in understanding IBD pathology, the mechanisms underlying pain remain poorly defined. While studies of ti...
Population-Level Activity Dissociates Preparatory Overt from Covert Attention
The neural signatures of preparing overt eye movements and directing covert spatial attention overlap as they recruit the same brain areas. Yet, these neural signatures are dissociable at the single c...
Emotional and Social Dimension of Abstract Concepts Meet with Interoception in Right Anterior Insula
According to the embodied cognition theory, which claims that concepts’ representation is grounded in sensory and motor components, abstract concepts are grounded in interoception, which is processed...
Sex and Stress Govern the Function and Innervation of a Basolateral Amygdala to Nucleus Accumbens Corticotropin-Releasing Hormone/GABA-Expressing Projection
Motivated behaviors are executed by refined brain circuits. Early-life adversity (ELA) is a risk for human affective disorders involving dysregulated reward behaviors. In mice, ELA causes anhedonia-li...
Discovery, Interruption, and Updating of Auditory Regularities in Memory: Evidence from Low-Frequency Brain Dynamics in Human MEG
During passive listening, the brain maintains a hierarchy of predictive models to monitor the statistics of its surroundings. The automatic discovery of regular patterns has been associated with a gra...
The Highly Localized Interaction between Neurofascin-186 and Gliomedin Promotes Subcellular Innervation by the Chandelier Cell
A variety of cortical inhibitory interneuron (IN) subtypes differentially but coordinately operate in local circuits to process neuronal signals. The subcellular arrangement of IN synaptic outputs con...
Neural Patterns Reflect Shared Emotional History
Emotions shape episodic memories, with emotional context—the affective quality or “hue” of an experience—persisting as part of the event in memory, scaffolding connections between events, and guiding...
Presynaptic Trafficking of Glutamate Decarboxylase Isoforms Is Dispensable for Basal GABAergic Neurotransmission
Two major glutamate decarboxylase isoforms (i.e., GAD65 and GAD67) together synthesize the majority of γ-aminobutyric acid (GABA) in our nervous system. However, the subcellular distribution of these...
Dynamic Respiration–Neural Coupling in Substantia Nigra across Sleep and Anesthesia
Respiration is increasingly recognized as a coordinator of neural activity across widespread brain regions and behavioral states. Even during sleep, respiration rhythms modulate sleep-related oscillat...
Temporal and Spatial Scales of Human Resting-State Cortical Activity across the Lifespan
Sensorimotor and cognitive abilities undergo substantial changes throughout the human lifespan, but the corresponding changes in the functional properties of cortical networks remain poorly understood...
Is the Whole the Sum of its Parts? Neural Computation of Consumer Bundle Valuation in Humans
Humans are often tasked with making decisions about bundles of multiple items and very little is known about how the human brain aggregates, computes, and represents value in such cases. We investigat...
Orientation Maps in Mouse Superior Colliculus Explained by Population Model of Non-Orientation Selective Neurons
Mouse superficial superior colliculus (sSC) has been found to have orientation selective maps, suggesting a fundamentally different selectivity than in primate SC. Moreover, orientation selectivity in...