Journal of Neuroscience
Articles in this Issue
Breath, Belief, and Brain: A Tripartite Map of Respiratory Interoception
The Sensory Basis of Planarian Behavior
Over the past few decades, planarians have emerged as a powerful model for regeneration research. Planarians can repair and regenerate their entire nervous system—including their brain and nerve cords...
Activity-Dependent Regulation of Basal Forebrain Cholinergic Neurons by Striatal Spiny Projection Neurons
The basal forebrain cholinergic neurons (BFCNs) in substantia innominata (SI) and nucleus basalis magnocellularis (nBM) provide dense innervation to multiple cortical areas, shaping cognition, attenti...
Circadian Changes in CA1 LTP Are Driven by Shifts in Excitation–Inhibition Balance and Reverse Direction after Puberty in Mice
Long-term potentiation (LTP), the best-characterized form of Hebbian synaptic plasticity, is well known to be under strong circadian regulation. In mice and rats, both nocturnal species, most studies...
RGR-Mediated Photopic Visual Cycle and Oxidative Stress: Potential Mechanisms for Cone Vision Impairment and Retinal Degeneration in Retinitis Pigmentosa Linked to D1080N-IRBP
Interphotoreceptor retinoid-binding protein (IRBP), an extracellular glycoprotein, supports cone-mediated vision through unclear molecular mechanisms. Over 30 different mutations in the...
Anterior Insula Activity during Alcohol and Social Reward Self-Administration and Choice in Male and Female Rats
Alcohol use disorder (AUD) is characterized by the prioritization of alcohol over healthier nonalcohol rewards, posing significant challenges for addiction treatment. Understanding the neural mechanis...
Temporal Variability in the Spiking Activity of Neurons in the External Globus Pallidus in Healthy and Parkinsonian Monkeys
The external segment of the globus pallidus (GPe) is a critical node within the indirect pathway of the basal ganglia. In vivo recordings in primates and other animals have shown that most GPe neurons...
Movie Features Are Hierarchically Encoded in the Dynamics of Functional Connectivity
The perception of the external environment relies on a cascade of neural computations in the visual cortex, where stimulus features are represented hierarchically. These features can be extracted thro...
Probabilistic Perceptual Decisions during Navigation Are Driven by a Small Subpopulation of Neurons in a Single Cortical Column of the Primary Somatosensory Cortex
Perceptually driven behavioral choices are thought to develop gradually from sensation to perception in the somatosensory cortex to guide decision-making in higher-order cortical areas. The primary so...
The Role of Disulfide Bonds in the GluN1 Subunit in the Early Trafficking and Functional Properties of GluN1/GluN2 and GluN1/GluN3 NMDA Receptors
N -Methyl- d -aspartate receptors (NMDARs) are ionotropic glutamate receptors essential for excitatory neurotransmission. Previous studies p...
Concurrent Multimodal Imaging Demonstrates That EEG-Based Excitation/Inhibition Balance Reflects Glutamate and GABA Balance
Magnetic resonance spectroscopy (MRS)-derived excitation/inhibition (E/I) ratio is recognized as a valuable index of attentional modulation, the plasticity and stability of learning states, and disord...
Integration of Memory and Sensory Information in Skilled Sequence Production
Sequential movements rely on two information sources: external sensory cues and internal memory representations. Although often both sources jointly drive sequential behavior, previous research has pr...
Progressive Supranuclear Palsy PERK Haplotype B Selectively Translates DLX1 Promoting Tau Toxicity
The unfolded protein response (UPR) sensor PERK exists in haplotypes A and B. PERK-B confers increased risk for tauopathies like progressive supranuclear palsy (PSP), but the mechanisms distinguishing...
Synaptic Facilitation Enhances the Reliability and Precision of High-Frequency Neurotransmission
The small and tortuous volume of synaptic clefts limits the diffusion of Ca 2+ ions during high-frequency spiking. Extracellular Ca 2+...